Implants and methods for correcting tissue defects

• US 8,795,377 B2
• Filed: 03/10/2011
• Issued: 08/05/2014
• Est. Priority Date: 03/10/2010
• Status: Active Grant

• Current Assignee: Ossdsign AB
• Original Assignee: Ossdsign AB
• Inventors: Engqvist, Hkan, berg, Jonas, Bohlin, Jan, Engstrand, Thomas
• Primary Examiner(s): STEWART, JASON-DENNIS NEILKEN
• Application Number:
  US13/583,465
• Publication Number:
  US 20120330435A1
• Time in Patent Office: 1,244 Days
• Field of Search: 623/11.11, 623/16.11, 623 1717- 1719, 606 69- 71
• US Class Current: 623/17.19
• CPC Class Codes: A61B 17/8085 with pliable or malleable elements or having a mesh-like structure, e.g. small strips A61B17/8071, A61B17/8076 take precedence
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2090/037 with a frangible part, e.g. by reduced diameter
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/2875 Skull or cranium A61F2/2803 and A61F2/3099 take precedence
• CPC Class Codes: A61F 2/30965 Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
• CPC Class Codes: A61F 2002/30143 hexagonal
• CPC Class Codes: A61F 2002/30462 retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/026 Ceramic or ceramic-like structures, e.g. glasses

Abstract

The present invention relates to mosaic implant (15) comprising a plurality of mosaic plates (17) connected by a wire or mesh anchoring arrangement (9). Methods for forming such implants and methods for using said implants for correction of bone and soft tissue defects are described.

Claims

1. An implant comprising a plurality of discrete biocompatible molded cement mosaic plates of thickness d connected by wire arms molded into and extending substantially laterally from the mosaic plates, wherein neighbouring mosaic plates are separated by a gap of width t.

2. An implant according to claim 1 wherein at least two neighbouring mosaic plates are joined together by a skin which has a thickness s which is less than thickness d.

3. An implant according to claim 1 wherein each mosaic plate has a maximum width w which is between 2 and 20 millimetres.

4. An Mosaic implant according to claim 3 wherein thickness d is between 10% and 150% of w.

5. An implant according to claim 4 wherein thickness d is between 20% and 130% of w.

6. An implant according to claim 4 wherein thickness d is between 50% and 130% of w.

7. An implant according to claim 3 wherein each mosaic plate has a maximum width w between 3 and 15 mm.

8. An implant according to claim 3 wherein each mosaic plate has a maximum width w between 4 and 10 mm.

9. A method of forming an implant according to claim 1, wherein the method comprises the steps of moulding a cement composition around a wire or mesh and subsequently allowing said cement composition to cure.

10. A method according to claim 9 comprising the steps of:

a) providing a mould with a plurality of cavities of depth d, each of which has the shape of a mosaic plate, wherein each cavity has a closable bottom end and is open at the opposite end to allow filling of the cavity, wherein each wall between adjacent cavities is pierced by at least one narrow, wire- or mesh-retaining channel of width ww;

b) placing a wire or mesh in each wire- or mesh-retaining channel,

c) filling said mould cavaties with a cement composition, and

d) allowing said cement to harden.

11. A method according to claim 9 comprising the steps of:

i) providing a first mould half with a plurality of cavities of depth dl, each of which has the shape of a mosaic plate, wherein each cavity has a closable bottom end and is open at the opposite end to allow filling of the cavity,

ii) filling said first mould half cavities with an excess of cement composition;

iii) placing a wire or mesh over the open ends of said cavities;

iv) placing a second mould half which has cavities of depth d2 arranged as a minor-image of the first mould half on top of the wire or mesh and compressing it towards the first mould half; and

v) allowing said cement to harden.

12. A method according to claim 9 wherein the cement composition is a non-aqueous hydraulic cement composition.

13. A method according to claim 9 wherein the step of allowing said cement to harden takes place in a wet environment.

14. A method according to claim 9 wherein the step of allowing said cement to harden takes place in a moist environment.

15. A method of implanting an implant in accordance with claim 1 in a patient, comprising the steps of:

i) exposing at least some of the tissue of the patient surrounding the area where the implant is to be placed,

ii) forming the implant to the desired shape,

iii) attaching the implant to tissue, and

iv) closing the exposure.

16. A method according to claim 15 wherein the step of attaching the implant to the tissue is achieved by using sutures and/or clamps and/or screws and/or plates with screws.

17. An implant according to claim 1 wherein the molded cement mosaic plates comprise Monetite.

18. An implant according to claim 17, wherein the mosaic plates comprising Monetite are formed from an acidic cement composition comprising beta-tricalcium phosphate and monocalcium phosphate monohydrate.

19. An implant according to claim 1 wherein each mosaic plate has a maximum width w between 2 and 20 millimeters and thickness d between 50% and 130% of w.

20. An implant according to claim 1, wherein each mosaic plate has a top surface and a bottom surface, and at least one of top surface and the bottom surface is exposed.

21. A method of implanting an implant in accordance with claim 1 in a patient, comprising the steps of:

i) exposing at least some of the tissue of the patient surrounding the area where the implant is to be placed,

ii) attaching the implant to tissue, wherein the implant has been shaped to fit a defect in the tissue, and

iv) closing the exposure.

22. An implant comprising a plurality of discrete biocompatible hexagonal moulded cement mosaic plates of maximum width w, wherein w is from 4 to 10 mm, and thickness d, wherein d is from 50% to 130% of w, connected by wire arms moulded into and extending substantially laterally from the mosaic plates, wherein neighbouring mosaic plates are separated by a gap of width t, and t is less than 3 mm, and wherein the mosaic plates comprise Monetite.