Needle-to-needle electrospinning

• US 8,795,577 B2
• Filed: 01/23/2012
• Issued: 08/05/2014
• Est. Priority Date: 11/30/2007
• Status: Active Grant

• Current Assignee: Cook Medical Technologies, LLC (Cook Group Incorporated)
• Original Assignee: Cook Medical Technologies, LLC (Cook Group Incorporated)
• Inventors: Orr, David E., Moore, William F., Vad, Siddharth
• Primary Examiner(s): HAUTH, GALEN H
• Application Number:
  US13/356,324
• Publication Number:
  US 20120141656A1
• Time in Patent Office: 925 Days
• Field of Search: 264/441, 427/471.1
• US Class Current: 264/441
• CPC Class Codes: B05B 5/0255 spraying and depositing by electrostatic forces only
• CPC Class Codes: B05B 5/08 Plant for applying liquids or other fluent materials to objects
• CPC Class Codes: B05B 5/087 Arrangements of electrodes, e.g. of charging, shielding, collecting electrodes B05B5/12, B05B5/14 take precedence; arrangements of electrodes on the discharge apparatus B05B5/0533
• CPC Class Codes: B05B 5/12 specially adapted for coating the interior of hollow bodies
• CPC Class Codes: B05D 1/04 involving the use of an electrostatic field B05D1/025 and B05D1/14 take precedence
• CPC Class Codes: B05D 2252/10 Applying the material on both sides
• CPC Class Codes: B05D 2254/02 Applying the material on the exterior of the tube
• CPC Class Codes: B05D 2254/04 Applying the material on the interior of the tube
• CPC Class Codes: D01D 5/0061 characterised by the electro-spinning apparatus
• CPC Class Codes: D01D 5/0084 Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses

Abstract

An electrospinning apparatus may include a first spinneret and a second spinneret, each including a reservoir and an orifice. The first and second spinnerets may have first and second electrical charges, respectively. The first spinneret orifice may be located substantially opposite the second spinneret orifice. The first and second spinnerets may be used to prepare a medical device defining a lumen with a proximal end, a distal end, a luminal surface and an abluminal surface. The first spinneret orifice distal end may be configured to be located outside of the medical device lumen and between about 0.1 inches and about 6.0 inches from the medical device abluminal surface. The second spinneret orifice distal end may be configured to be located in the medical device lumen and between about 0.1 inches and about 6.0 inches from the medical device luminal surface.

Claims

1. A method for preparing a medical device, the method comprising:

providing the medical device, the medical device comprising a first surface and an opposing second surface;

providing an electrospinning apparatus, the electrospinning apparatus comprising a first spinneret and a second spinneret located substantially opposite the first spinneret, the first spinneret comprising a reservoir and an orifice fluidly coupled to the first spinneret reservoir, the second spinneret comprising a reservoir and an orifice fluidly coupled to the second spinneret reservoir;

applying a first electrical charge to the first spinneret;

applying a second electrical charge to the second spinneret, a sign of the second electrical charge being the same as a sign of the first electrical charge;

applying a third electrical charge to the medical device, a sign of the third electrical charge being opposite of the sign of the first electrical charge and the sign of the second electrical charge;

locating the first spinneret orifice nearby the medical device first surface;

locating the second spinneret orifice nearby the medical device second surface;

simultaneously electrospinning a first solution onto the medical device first surface with the first spinneret and a second solution onto the medical device second surface with the second spinneret.

2. The method of claim 1, further comprising moving the medical device relative to the first spinneret orifice or the second spinneret orifice and simultaneously electrospinning the first solution about a length or a width of the medical device first surface and the second solution about a length or a width of the medical device second surface.

3. The method of claim 1, wherein an electrical conductivity of the first solution is different than an electrical conductivity of the second solution.