Sensor substrate systems and methods

• US 8,795,595 B2
• Filed: 04/30/2010
• Issued: 08/05/2014
• Est. Priority Date: 04/07/2010
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Shah, Rajiv
• Primary Examiner(s): Alexander, Lyle
• Application Number:
  US12/772,050
• Publication Number:
  US 20110248184A1
• Time in Patent Office: 1,558 Days
• Field of Search: 422/401, 422/68.1, 422/82.05, 422/82.07, 422/82.08, 436/164, 436/172, 436/91, 436/95, 600/322, 600/342, 600/347, 600/365
• US Class Current: 422/82.07
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: Y10T 29/49002 Electrical device making
• CPC Class Codes: Y10T 436/14 Heterocyclic carbon compound [i.e. , O, S, N, Se, Te, as only ring hetero atom]
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

A sensing apparatus may include a substrate having a first side for a sensing element and a second side for electronics, the substrate may have a at least one via from the first side of the substrate to the second side of the substrate, the at least one via may be hermetically sealed with an optically transmissive material.

Claims

1. A sensing apparatus comprising:

a planar substrate having a first side and a second side that is opposite and parallel to said first side, wherein the substrate defines therethrough a via, said via being a pathway that extends from said first side to said second side of the substrate;

a sensing element disposed on said first side, wherein the sensing element is configured to sense an analyte; and

electronics disposed on said second side, wherein the electronics include an illumination device for illuminating the analyte,

wherein the via is hermetically sealed from the first side of the substrate to the second side of the substrate, wherein the via is at least partially filled with an optically transmissive material, and wherein the via is at least partially filled with an additional material, said additional material comprising an electrically conductive material other than air.

2. The sensing apparatus of claim 1, wherein the optically transmissive material comprises a fritted glass material.

3. The sensing apparatus of claim 2, wherein the flitted glass material comprises at least one of quartz and silica.

4. The sensing apparatus of claim 1, wherein the optically transmissive material is concentrically arranged with respect to the electrically conductive material.

5. The sensing apparatus of claim 1, wherein the electrically conductive material comprises a fritless ink.

6. The sensing apparatus of claim 1, wherein the electrically conductive material comprises an indium tin oxide.

7. The sensing apparatus of claim 1, wherein the substrate is made of a material comprising ceramic.

8. The sensing apparatus of claim 1, wherein the substrate defines therethrough a plurality of separate vias, each of said plurality of vias being a pathway that extends from said first side to said second side of the substrate.

9. The sensing apparatus of claim 8,

wherein at least one of the plurality of vias is at least partially filled with an optically transmissive material;

and

wherein at least one other of the plurality of vias is at least partially filled with an additional material, said additional material comprising an electrically conductive material other than air.

10. The sensing apparatus of claim 1, wherein the substrate is annealed.

11. The sensing apparatus of claim 9, wherein each via that is at least partially filled with the optically transmissive material is polished.

12. The sensing apparatus of claim 1, wherein the sensing element senses a fluorescence resonance energy transfer of the analyte.

13. The sensing apparatus of claim 1, wherein the illumination device comprises at least one of a light emitting device, a vertical cavity surface emitting laser, and an edge emitting laser.

14. The sensing apparatus of claim 1, wherein the illumination device is arranged to illuminate the analyte through the via in the substrate.

15. The sensing apparatus of claim 1, the electronics comprising a sensor for measuring a returned fluorescence from the sensing element.

16. The sensing apparatus of claim 15, wherein the sensor is arranged to sense the returned fluorescence from the sensing element through the via in the substrate.

24. The sensing apparatus of claim 1, wherein the via is perpendicular to both the first and the second sides of the substrate.

25. The sensing apparatus of claim 1, wherein the sensing element is disposed directly on said first side of the substrate.

26. The sensing apparatus of claim 25, wherein the electronics are disposed directly on said second side of the substrate.

27. The sensing apparatus of claim 5, wherein the fritless ink includes at least one of a gold paste and a platinum paste.

17. A method of manufacturing a sensing apparatus, the method comprising:

providing a planar substrate having a first side and a second side that is opposite and parallel to said first side;

forming at least one via through the substrate, wherein said at least one via is a pathway that extends from the first side of the substrate to the second side of the substrate;

filling the at least one via at least partially with an optically transmissive material and at least partially with an additional material, said additional material comprising an electrically conductive material other than air, such that the at least one via is hermetically sealed from the first side of the substrate to the second side of the substrate;

arranging on said first side of the substrate a sensing element configured to sense an analyte; and

arranging electronics on said second side of the substrate, said electronics including an illumination device.

18. The method of claim 17, wherein the illumination device is an optical emitting device to pass light through the at least one via to the first side of the substrate, the method further comprising:

arranging a receiving device on the second side of the substrate; and

arranging an optically detectable material that is reactive in an optically detectable manner on the first side of the substrate to receive light from the optical emitting device and is optically detectable through the at least one via by the receiving device.

19. The method of claim 18, wherein the sensing element is disposed directly on the first side of the substrate.

20. The method of claim 19, wherein the illumination device and the receiving device are disposed directly on the second side of the substrate.

21. The method of claim 17, wherein, after forming the at least one via, the method further includes annealing the substrate.

22. The method of claim 17, wherein, after filling the at least one via, the method further includes firing the substrate so as to harden the electrically conductive material is inside said at least one via.

23. The method of claim 17, wherein said at least one via is formed so as to be perpendicular to both the first and the second sides of the substrate.