Liquid filled delivery system

• US 8,795,720 B2
• Filed: 08/29/2006
• Issued: 08/05/2014
• Est. Priority Date: 09/09/2005
• Status: Active Grant

• Current Assignee: Capsugel Belgium NV (Lonza Group AG)
• Original Assignee: Capsugel Belgium NV (Lonza Group AG)
• Inventors: Madit, Nicolas
• Primary Examiner(s): LOVE, TREVOR M
• Application Number:
  US11/511,808
• Publication Number:
  US 20070059355A1
• Time in Patent Office: 2,898 Days
• Field of Search: None
• US Class Current: 424/455
• CPC Class Codes: A61K 31/205 Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
• CPC Class Codes: A61K 9/4816 Wall or shell material
• CPC Class Codes: A61K 9/4858 Organic compounds

Abstract

The present invention provides a delivery system comprising: (a) a container which is a formed body obtained from a film forming composition comprising at least one polysaccharide or polysaccharide derivative; (b) a liquid fill comprising a matrix composition of at least one solvent which is both polar and hygroscopic or a mixture of solvents each of which is both polar and hygroscopic; and (c) an active agent or a mixture of active agents wherein the active agent is soluble in said polar and hygroscopic solvent or mixture of polar and hygroscopic solvents, and a process for the preparation of said delivery system.

Claims

1. A delivery system comprising:

(a) a hard capsule comprising hydroxypropylmethyl cellulose (HPMC);

(b) a liquid fill comprising at least one solvent which is both polar and hygroscopic or a mixture of solvents each of which is both polar and hygroscopic, wherein at least one solvent is glycerol; and

(c) an active agent or a mixture of active agents, wherein the active agent is solubilized in said polar and hygroscopic solvent or mixture of polar and hygroscopic solvents.

2. The delivery system according to claim 1, wherein the system further comprises water.

3. The delivery system according to claim 1, further comprising at least one coating.

4. The delivery system according to claim 1, wherein the active agent is selected from the group consisting of dietary supplements, pharmaceuticals, amino acids, vitamins, and herbals.

5. The delivery system according to claim 4, wherein the dietary supplement is selected from the group consisting of calcium supplements, mineral supplements, garlic, ginseng, ginkgo biloba, Echinacea purpurea, Echinacea angustifolia, St John'"'"'s wort, royal jelly, artichoke, aloe vera, red clover, Carnitine, L-Carnitine, L-Carnitine acetyl, L-Carnitine Tartrate, L-Carnitine hydrochloride, S-Adenosyl methionine (SAM-e), S-adenosyl methionin tosylate, a combination of glycosamine and chondroitine, and a combination of a salt of glycosamine and chondroitine.

6. The delivery system according to claim 1, wherein the liquid fill further optionally comprises at least one coloring agent in an amount ranging from about 0% to about 10% based upon the weight of the liquid.

7. The delivery system according to claim 5, further comprising at least one coating.