Tissue scaffold
First Claim
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1. A tissue scaffold comprising:
- a first film comprising a plurality of cell openings; and
a second film adjacent the first film and comprising a plurality of cell openings offset in a predetermined arrangement from the cell openings of the first film;
wherein the cell openings of the first film interconnect with the cell openings of the second film to define pathways with interconnecting pores of controlled area extending from the first film to the second film; and
wherein the diameter of a majority of the pores is less than the diameter of the cell openings of the first and second films that define each pore.
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Abstract
A tissue scaffold includes a first film having a plurality of cell openings and a second film adjacent the first film and having a plurality of cell openings larger than the cell openings of the first film. The cell openings of the first film interconnect with the cell openings of the second film to define pathways extending through the first and second films.
37 Citations
25 Claims
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1. A tissue scaffold comprising:
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a first film comprising a plurality of cell openings; and a second film adjacent the first film and comprising a plurality of cell openings offset in a predetermined arrangement from the cell openings of the first film; wherein the cell openings of the first film interconnect with the cell openings of the second film to define pathways with interconnecting pores of controlled area extending from the first film to the second film; and wherein the diameter of a majority of the pores is less than the diameter of the cell openings of the first and second films that define each pore. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A tissue scaffold comprising:
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a first film including a first porosity; and a second film joined to the first film and including a second porosity greater than the first porosity; and a plurality of delivery channels extending through the first and second films in a predetermined arrangement; wherein the first porosity and the second porosity define a controlled porosity gradient extending from the first to the second film to selectively promote cellular regeneration along the gradient; and wherein the diameter of a majority of the delivery channels is less than the diameter of the cell openings of the first and second films that define each channel.
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19. A tissue scaffold comprising:
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a first film including a plurality of cell openings; and a second film adjacent the first film, the second film including a plurality of cell openings and alignment holes; wherein the alignment holes align the cell openings of the first film with the cell openings of the second film such that the cell openings of the first film interconnect with the cell openings of the second film to define pathways with interconnecting pores of controlled area extending from the first film to the second film; and wherein the diameter of a majority of the pores is less than the diameter of the cell openings of the first and second films that define each pore. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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Specification