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Method and system for delta double sampling

  • US 8,796,036 B2
  • Filed: 06/30/2011
  • Issued: 08/05/2014
  • Est. Priority Date: 09/24/2010
  • Status: Active Grant
First Claim
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1. A method for detecting a chemical reaction, the method comprising:

  • inducing a chemical reaction within a well coupled to a chemically-sensitive transistor, the chemically-sensitive transistor selectively coupled to a circuit node via a select transistor;

    operating the select transistor in a first mode during a first time interval of the chemical reaction, and sampling a reference signal at the circuit node;

    operating the select transistor in a second mode during a second time interval of the chemical reaction, and sampling a sensor signal at the circuit node; and

    normalizing the sampled sensor signal using the sampled reference signal to produce an output signal.

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