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Tri- or tetraspecific antibodies

  • US 8,796,424 B2
  • Filed: 05/27/2010
  • Issued: 08/05/2014
  • Est. Priority Date: 05/27/2009
  • Status: Active Grant
First Claim
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1. A trispecific or tetraspecific antibody, comprising:

  • a) a light chain comprising a light chain variable domain VL and a light chain constant domain CL, and a heavy chain comprising a heavy chain variable domain VH and heavy chain constant domains CH1, CH2, and CH3, wherein the light chain and the heavy chain specifically bind to a first antigen; and

    b) a modified light chain and a modified heavy chain that specifically bind to a second antigen, wherein;

    (i) the modified light chain comprises in N-terminal to C-terminal direction VL, CH1, and the modified heavy chain comprises in N-terminal to C-terminal direction VH, CL, CH2, and CH3;

    (ii) the modified light chain comprises in N-terminal to C-terminal direction VH, CL, and the modified heavy chain comprises in N-terminal to C-terminal direction VL, CH1, CH2, and CH3;

    or(iii) the modified light chain comprises in N-terminal to C-terminal direction VH, CH1, and the modified heavy chain comprises in N-terminal to C-terminal direction VL, CL, CH2, and CH3;

    andc) one to four antigen binding peptides fused via a peptide connector to the C- or N-terminus of the light chains or heavy chains of a) and/or b) wherein said antigen binding peptides specifically bind one or two further antigens.

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