Method for non-invasive measurement of cardiac output
First Claim
1. A method for non-invasively performing an examination to determine selected physical characteristics of the heart and cardiovascular system of a living subject, said method comprising the steps of:
- selecting an extremity of the subject suitable for conducting said examination;
providing an apparatus for use in performing MRI analysis of living tissue;
said apparatus comprising;
a cylindrical housing formed from magnetically conductive material,said housing having a housing wall defining a space there within and having first and second open ends;
a first permanent magnet arrangement comprising;
a first main magnet formed as a right cylindrical solid having a central axis, an outer wall and first and second opposed faces perpendicular to said main magnet central axis;
a first pole piece formed from ferromagnetic material, said first pole piece having a central axis and first and second opposed pole piece faces perpendicular to said first pole piece central axis, the first of said pole piece faces being positioned at and coextensive with said first main magnet first face;
a first side magnet, said side magnet having an inner opening sized and shaped to match the outer dimensions of said first pole piece, said first side magnet positioned about the outer periphery of said first pole piece;
providing at least a first cavity within said first pole piece, placing a first shim within said first cavity,adjusting the magnetic flux created by said first permanent magnet arrangement by altering the selected orientations and positions of said first shim within said first cavity;
said first permanent magnet arrangement positioned within said housing proximate said first open end with said first side magnet contacting said housing wall;
a second permanent magnet arrangement comprising;
a second main magnet formed as a right cylindrical solid having a central axis, an outer wall and first and second opposed faces perpendicular to said second main magnet central axis;
a second pole piece formed from ferromagnetic material, said second pole piece having a central axis and first and second opposed pole piece faces perpendicular to said second pole piece central axis, the first of said pole piece faces of the second pole piece being positioned at and coextensive with said second main magnet first face;
a second side magnet, said second side magnet having an inner opening sized and shaped to match the outer dimensions of said second pole piece, said second side magnet positioned about the outer periphery of said second pole piece; and
,providing at least a first cavity within said second pole piece, placing a first shim within said first cavity, and adjusting the magnetic flux created by said second permanent magnet arrangement, by altering the selected orientations and positions of said first shim within said first cavity, said second permanent magnet arrangement positioned within said housing proximate said second open end with said second side magnet contacting said housing wall;
said first and second permanent magnet arrangements spaced apart one from another with said second pole piece face of said first permanent magnet arrangement first pole piece facing said second pole piece face of said second permanent magnet arrangement second pole piece;
said first and second permanent magnet arrangements and said housing wall defining there between an air gap; and
an access port formed in said housing wall allowing said tissue to be positioned within said air gap;
providing a first array of RF coils to pulse and detect electromagnetic signals within said air gap;
pulsing selected of said RF coils and detecting the signals produced thereby;
creating an MRI image of selected blood vessels at selected time intervals to produce information to determine said heart and cardiovascular system characteristics; and
collecting and analyzing said information;
wherein said heart and cardiovascular system characteristics are determinable accurately within high strength uniform and high resolution magnetic field across a portion of the body.
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Accused Products
Abstract
A comparatively light and compact permanent magnet arrangement for an MRI apparatus has a pair of opposed permanent magnet arrays with a shimming system to adjust the uniformity and strength of a magnetic field in a central chamber of the apparatus. The MRI apparatus is used to examine the extremities of a patient to determine cardiovascular characteristics from an analysis of the blood flow through selected arteries in the extremity. The information collected can be used to calculate such characteristics as total cardiac output, blood flow, arterial wall thickness and elasticity and the presence of plaque.
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Citations
15 Claims
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1. A method for non-invasively performing an examination to determine selected physical characteristics of the heart and cardiovascular system of a living subject, said method comprising the steps of:
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selecting an extremity of the subject suitable for conducting said examination; providing an apparatus for use in performing MRI analysis of living tissue;
said apparatus comprising;a cylindrical housing formed from magnetically conductive material, said housing having a housing wall defining a space there within and having first and second open ends; a first permanent magnet arrangement comprising; a first main magnet formed as a right cylindrical solid having a central axis, an outer wall and first and second opposed faces perpendicular to said main magnet central axis; a first pole piece formed from ferromagnetic material, said first pole piece having a central axis and first and second opposed pole piece faces perpendicular to said first pole piece central axis, the first of said pole piece faces being positioned at and coextensive with said first main magnet first face; a first side magnet, said side magnet having an inner opening sized and shaped to match the outer dimensions of said first pole piece, said first side magnet positioned about the outer periphery of said first pole piece; providing at least a first cavity within said first pole piece, placing a first shim within said first cavity, adjusting the magnetic flux created by said first permanent magnet arrangement by altering the selected orientations and positions of said first shim within said first cavity; said first permanent magnet arrangement positioned within said housing proximate said first open end with said first side magnet contacting said housing wall; a second permanent magnet arrangement comprising; a second main magnet formed as a right cylindrical solid having a central axis, an outer wall and first and second opposed faces perpendicular to said second main magnet central axis; a second pole piece formed from ferromagnetic material, said second pole piece having a central axis and first and second opposed pole piece faces perpendicular to said second pole piece central axis, the first of said pole piece faces of the second pole piece being positioned at and coextensive with said second main magnet first face; a second side magnet, said second side magnet having an inner opening sized and shaped to match the outer dimensions of said second pole piece, said second side magnet positioned about the outer periphery of said second pole piece; and
,providing at least a first cavity within said second pole piece, placing a first shim within said first cavity, and adjusting the magnetic flux created by said second permanent magnet arrangement, by altering the selected orientations and positions of said first shim within said first cavity, said second permanent magnet arrangement positioned within said housing proximate said second open end with said second side magnet contacting said housing wall; said first and second permanent magnet arrangements spaced apart one from another with said second pole piece face of said first permanent magnet arrangement first pole piece facing said second pole piece face of said second permanent magnet arrangement second pole piece; said first and second permanent magnet arrangements and said housing wall defining there between an air gap; and an access port formed in said housing wall allowing said tissue to be positioned within said air gap; providing a first array of RF coils to pulse and detect electromagnetic signals within said air gap; pulsing selected of said RF coils and detecting the signals produced thereby; creating an MRI image of selected blood vessels at selected time intervals to produce information to determine said heart and cardiovascular system characteristics; and
collecting and analyzing said information;
wherein said heart and cardiovascular system characteristics are determinable accurately within high strength uniform and high resolution magnetic field across a portion of the body.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for non-invasively performing an examination to determine selected physical characteristics of the heart and cardiovascular system of a living subject, said method comprising the steps of:
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selecting an extremity of the subject suitable for conducting said examination; providing a first permanent magnet arrangement and a second permanent magnet arrangement for use in an apparatus performing MRI analysis of living tissue;
said second permanent magnet arrangement is placed in face-to-face relationship with said first permanent magnet arrangement, and spaced apart from said first permanent magnet arrangement to form an air gap there between;said first permanent magnet arrangement comprising; a main magnet formed as a right cylindrical solid having a central axis, an outer wall and first and second opposed faces perpendicular to said main magnet central axis; a first pole piece formed from ferromagnetic material, said first pole piece having a central axis and first and second opposed pole piece faces perpendicular to said first pole piece central axis, the first of said first pole piece faces being positioned at and coextensive with said main magnet first face; a side magnet, said side magnet having an inner opening sized and shaped to match the outer dimensions of said first pole piece, said side magnet positioned about the outer periphery of said first pole piece; providing first, second and third cavities within said first pole piece, said first cavity formed in the shape of a right circular cylinder, each of said second and third cavities provided in the shape of a circular channel, said first, second and third cavities being concentric one with the other and being centered with respect to said first pole piece central axis, providing a first shim dimensioned to fit within and positioned within said first cavity, a second shim dimensioned to fit within and positioned within said second cavity, and a third shim dimensioned to fit within and positioned within said third cavity; and providing a plurality of bolts rotatably journaled to each said shim, each said bolt being individually axially adjustable with respect to said first pole piece whereby each said shim may be positioned within each said cavity toward or away from said air gap and whereby each said shim may be positioned in parallel with respect to said first pole piece central axis; adjusting the magnetic flux created by said first permanent magnet arrangement by altering the position of each said shim within each said cavity by applying said bolts; said second permanent magnet arrangement comprising; a main magnet formed as a right cylindrical solid having a central axis, an outer wall and first and second opposed faces perpendicular to said main magnet central axis; a second pole piece formed from ferromagnetic material, said second pole piece having a central axis and first and second opposed pole piece faces perpendicular to said second pole piece central axis, the first of said second pole piece faces being positioned at and coextensive with said main magnet first face; a side magnet, said side magnet having an inner opening sized and shaped to match the outer dimensions of said second pole piece, said side magnet positioned about the outer periphery of said second pole piece; providing first, second and third cavities within said second pole piece, said first cavity formed in the shape of a right circular cylinder, each of said second and third cavities provided in the shape of a circular channel, said first, second and third cavities being concentric one with the other and being centered with respect to said second pole piece central axis, providing a first shim dimensioned to fit within and positioned within said first cavity, a second shim dimensioned to fit within and positioned within said second cavity, and a third shim dimensioned to fit within and positioned within said third cavity; and providing a plurality of bolts rotatably journaled to each said shim, each said bolt being individually axially adjustable with respect to said second pole piece whereby each said shim may be positioned within each said cavity toward or away from said air gap and whereby each said shim may be positioned in parallel with respect to said second pole piece central axis; adjusting the magnetic flux created by said second permanent magnet arrangement by altering the position of each said shim within each said cavity by applying said bolts, providing an array of RF coils to pulse and detect electromagnetic signals within said air gap; pulsing selected of said RF coils and detecting the signals produced thereby; creating an MRI image of selected blood vessels at selected time intervals to produce information to determine said heart and cardiovascular system characteristics; and collecting and analyzing said information; wherein said heart and cardiovascular system characteristics are determinable accurately within a high strength uniform and high resolution magnetic field across a portion of the body. - View Dependent Claims (13, 14, 15)
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Specification