Delivery devices

• US 8,800,555 B2
• Filed: 08/29/2004
• Issued: 08/12/2014
• Est. Priority Date: 08/28/2003
• Status: Active Grant

• Current Assignee: OptiNose, Inc.
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle
• Primary Examiner(s): YOUNG, RACHEL T
• Application Number:
  US10/570,034
• Publication Number:
  US 20070125371A1
• Time in Patent Office: 3,635 Days
• Field of Search: 128/203.12, 12820314-20315, 12820318-20319, 12820323-20328, 128/200.14, 128/200.18, 128/204.17, 128/204.14, 128/200.23, 128/204.12, 222/630, 222/325, 222/541.1, 2225413-5416, 141/112, 141329-330, 220/601, 220/661, 220/86.1
• US Class Current: 128/203.18
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/0013 with inhalation check valves
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0031 by bursting or breaking the package, i.e. without cutting or piercing
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2202/30 Vaccines
• CPC Class Codes: A61M 2205/7518 bacterial

Abstract

A delivery device for and method of delivering a substance, the delivery device having an outlet member through which substance is in use delivered in an entraining gas flow, and a substance supply unit for supplying substance to be entrained by an entraining gas flow as one or both of a vapor or a fine aerosol mist, wherein the substance supply unit has a flow channel which is fluidly connected to the outlet member, and a substance supporting element for supporting substance, at least a surface of which is in use disposed in the flow channel.

Claims

1. A delivery device, comprising:

an outlet member through which substance is in use delivered in an entraining gas flow; and

a substance supply unit for supplying the substance to be entrained by the entraining gas flow as one or both of a vapor or a fine aerosol mist, wherein the substance supply unit comprises a flow channel which is fluidly connected to the outlet member through which the entraining gas flow is in use delivered and defines a receiving chamber for receiving a substance dosing unit, wherein the substance supply unit further comprises a dosing member which is movable between a first, open position which allows for introduction of the substance dosing unit into the receiving chamber and a second, closed position in which the receiving chamber is enclosed, and wherein the substance dosing unit comprises a flexible cartridge which contains the substance and is openable to enable release of the contained substance, wherein the cartridge comprises a body having two closure elements which normally close the body and are ruptured to enable release of the contained substance, and the dosing member is configured to open the cartridge during movement of the dosing member to the closed position by squeezing the cartridge and rupturing the closure elements, such that the entraining gas flow is adapted to be delivered through the cartridge from one closure element to the other closure element.

2. The delivery device of claim 1, wherein the cartridge includes a substance supporting element for supporting the substance therewithin.

3. The delivery device of claim 1, wherein the body is a tubular body.

4. The delivery device of claim 3, wherein the cartridge further comprises a porous, absorbent element which is disposed in the tubular body, over which the entraining gas flow is directed to entrain the substance therefrom.

5. The delivery device of claim 1, wherein the substance is formulated such as to provide for delivery of the entire dose of the substance in a single operation.

6. The delivery device of claim 1, wherein the substance supply unit further comprises a one-way inlet valve at an inlet end of the flow channel and a one-way outlet valve at an outlet end of the flow channel, which valves act normally to close the flow channel and prevent the escape of the substance therefrom, and, on exhalation through a mouthpiece, are opened to allow for the delivery of an exhalation air flow, as the entraining gas flow, through the flow channel and the receiving chamber.

7. The delivery device of claim 1, further comprising:

at least one filter element configured to filter the entraining gas flow.

8. The delivery device of claim 7, wherein the filter element comprises a first, anti-microbial filter adapted to filter microbes from the entraining gas flow and a second, drying filter adapted to de-humidify the entraining gas flow and thereby promote the uptake of the substance through the flow channel.

9. The delivery device of claim 1, wherein the body is oversized relative to a diametric dimension of the receiving chamber, such that, on insertion of the substance dosing unit and with closure of the dosing member, the body is squeezed diametrally to rupture the closure elements.