Ocular implant with anchor and methods thereof

• US 8,801,648 B2
• Filed: 02/05/2009
• Issued: 08/12/2014
• Est. Priority Date: 04/14/2000
• Status: Expired due to Term

• Current Assignee: Glaukos Corporation
• Original Assignee: Glaukos Corporation
• Inventors: Bergheim, Olav B, Gharib, Morteza
• Primary Examiner(s): MARCETICH, ADAM M
• Application Number:
  US12/366,565
• Publication Number:
  US 20090138081A1
• Time in Patent Office: 2,014 Days
• Field of Search: 604/8, 604/27, 604/93.01, 623/4.1, 606/4, 606/6
• US Class Current: 604/8
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: Y10S 623/905 Eye

Abstract

Implants and methods for treating ocular disorders are disclosed. One implant has an inlet portion configured to extend through a portion of a tissue of an eye and an outlet portion configured to extend into and along a physiologic outflow pathway of the eye. The implant provides a flow path between an anterior chamber of the eye and the physiologic outflow pathway. One implant includes a body having adjacent regions of differing cross-sectional dimensions configured to anchor the implant and/or stabilize at least a portion of the flow path through the implant. One method involves inserting a fiber optic in an eye, locating a distal end of the fiber optic at a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of the eye, and delivering a material comprising a therapeutic agent along the fiber optic and into the physiologic outflow pathway.

Claims

1. An ocular implant, comprising:

a body having a first portion having a first end and a second portion having a second end and a fluid flow path defined between at least one inlet and one outlet, said body including two smaller regions each having a cross-sectional size smaller than an intermediate region separating the two smaller regions, the two smaller regions also having a cross-sectional size being smaller than adjacent regions bordering the two smaller regions, said intermediate region and said adjacent regions extending around the full circumference of said body, said at least two smaller regions being disposed remote from the second end between said at least one inlet and one outlet, said body configured to conduct fluid from an anterior chamber of an eye to a physiologic outflow pathway of the eye,

wherein said second portion is sized and shaped to be inserted into and along a portion of a length of the physiologic outflow pathway of the eye,

and wherein said second portion consists of only one terminus.

2. The implant of claim 1, wherein the body comprises a plurality of outlets, and wherein at least one of the outlets is intermediate the first and second ends of the body.

3. The implant of claim 2, wherein a distal outlet of the plurality of outlets is located at a distal end of the second portion and an intermediate outlet of the plurality of outlets is located at a proximal end of the second portion.

4. The implant of claim 3, wherein the intermediate region and the adjacent regions are located between the intermediate outlet and the distal outlet.

5. The implant of claim 1, wherein the-second portion is appended from the first portion, and wherein the first portion includes a lumen.

6. The implant of claim 1, wherein the adjacent regions each comprise a ridge protruding radially outwardly from the outer surface of the body.

7. The implant of claim 1, wherein said second end has a uniform taper.

8. The implant of claim 1, wherein the intermediate region and the adjacent regions each comprise a ridge, wherein the two smaller regions each comprise a trough, and wherein the surface between each ridge and each trough is inclined with respect to an axis of the fluid flow path.

9. The implant of claim 1, wherein at least said first end of said first portion is sized and configured to be positioned in the anterior chamber of the eye.

10. The implant of claim 1, wherein the first portion and the second portion are angled with respect to each other.

11. The implant of claim 1, further comprising an egress port disposed along the flow path between the at least one inlet and the outlet.

12. The implant of claim 1, wherein the intermediate region and the adjacent regions are symmetrical about an axis of the fluid flow path.

13. An ocular implant, comprising:

an elongated body comprising a first portion having an inlet end and a second portion having an outlet end, the elongated body configured to extend through a tissue of an eye such that the inlet end resides in an anterior chamber of the eye and the outlet end resides in and along a portion of a length of a physiologic outflow pathway of the eye; and

an inner lumen within the elongated body, the lumen having an inlet port and a plurality of outlet ports for providing a fluid flow pathway through the elongated body;

wherein the elongated body comprises three regions each having a cross-sectional dimension greater than adjacent regions bordering each side of the three regions of the elongated body, said three regions disposed remotely of said outlet end between the inlet end and the outlet end, said three regions extending around the full circumference of said elongated body;

wherein said second portion is sized and shaped to be inserted into and to extend along a length of the physiologic outflow pathway of the eye, and

wherein said second portion consists of only one terminus.

14. The implant of claim 13, wherein at least a portion of the elongated body is tubular.

15. The implant of claim 13, wherein the three regions each comprise a ridge extending outward from an outer surface of the elongated body.

16. The implant of claim 13, wherein said outlet end has a uniform taper.

17. The implant of claim 13, wherein at least one of the outlet ports is intermediate the inlet end and the outlet end of the elongated body.

18. The implant of claim 13, wherein the three regions each comprise a ridge, wherein each of the adjacent regions comprises a trough, and wherein the surface between each ridge and each trough is inclined with respect to an axis of the fluid flow pathway.

19. The implant of claim 13, wherein the first portion and the second portion are angled with respect to each other.

20. The implant of claim 13, wherein a distal outlet port of the plurality of outlet ports is located at a distal end of the second portion and an intermediate outlet port of the plurality of outlet ports is located at a proximal end of the second portion.

21. The implant of claim 20, wherein the three regions are located between the intermediate outlet port and the distal outlet port.

22. The implant of claim 13, wherein the three regions are symmetrical about an axis of the fluid flow pathway.