At least partially resorbable reticulated elastomeric matrix elements and methods of making same

• US 8,801,801 B2
• Filed: 04/05/2010
• Issued: 08/12/2014
• Est. Priority Date: 04/03/2009
• Status: Active Grant

• Current Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Original Assignee: Biomerix Corp.
• Inventors: Datta, Arindam, Friedman, Craig, Haridas, Balakrishna, Lavelle, Lawrence R. Jr.
• Primary Examiner(s): MCEVOY, THOMAS M
• Application Number:
  US12/798,511
• Publication Number:
  US 20100256777A1
• Time in Patent Office: 1,590 Days
• Field of Search: 623/1.36, 623/1.39, 623/1.4, 623/1.41, 623/1.46, 623/1.49, 623/11.11, 623/14.12, 623/15.12, 623/23.72, 623/23.75, 623/23.76, 424/422, 424/424, 424/425, 521/50, 521/52, 521/117, 521/170, 521/172, 521/173
• US Class Current: 623/23.72
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 61/28 with melamine
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: C09D 175/04 Polyurethanes

Abstract

The present disclosure relates to reticulated elastomeric matrices, and more particularly to at least partially degradable elastomeric elements that are compressible and exhibit resilience in their recovery and that can be employed in diverse applications including, without limitation, biological implantation, especially in humans.

Claims

1. A matrix comprising a biocompatible, cross-linked, biodegradable, elastomeric polyurethane, the matrix having a continuous-interconnected void phase, wherein the matrix is configured to be implantable in a human body and to support a biological tissue in-growth, wherein the matrix comprises a biodegradable, polyol-derived soft segment and an isocyanate-derived hard segment, and wherein said matrix is reticulated, wherein the continuous-interconnected void phase extends from an interior portion to an exterior surface of said matrix;

wherein a path through the void phase can be drawn in a substantially linear direction across an entirely of said matrix beginning at any portion of an exterior surface of said matrix containing said void phase.

2. The matrix of claim 1, wherein said matrix is resilient.

3. The matrix of claim 1, wherein said matrix is reticulated to a Darcy permeability of at least 100.

4. The matrix of claim 1, wherein the matrix comprises an amount of glycerol.

5. The matrix of claim 1, wherein said isocyanate-derived hard segment is substantially free of chemical groupings selected from the group consisting of biuret, allophanate, and isocyanurate groups.

6. The matrix of claim 1, wherein said isocyanate-derived hard segment is biostable.

7. The matrix of claim 6, wherein said isocyanate hard segment comprises 4,4-MDI and 2,4-.

8. The matrix of claim 7 wherein said 2,4-MDI is present at from about 5% to about 50% relative to the amount of said 4,4-MDI.

9. The matrix of claim 1, wherein said isocyanate-derived hard segment is biodegradable.

10. The matrix of claim 9, wherein said biodegradable, isocyanate-derived hard segment comprises an aromatic diisocyanate.

11. The matrix of claim 10, wherein said aromatic diisocyanate is a hydrolytically-cleavable, bridged diphenyl diisocyanate.

12. The matrix of claim 9, wherein said biodegradable, isocyanate-derived hard segment comprises an aliphatic diisocyanate.

13. The matrix of claim 1, wherein said isocyanate-derived hard segment comprises an aliphatic diisocyanate.

14. The matrix of claim 13, wherein said aliphatic diisocyanate is selected from the group consisting of lysine methyl ester diisocyanate, lysine triisocyanate, 1,4-diisocyanatobutane, and mixtures thereof.

15. The matrix of claim 1, wherein said biodegradable polyol-derived soft segment comprises at least one moiety derived from a polycaprolactone polyol or copolymers of polycaprolactone polyol.

16. The matrix of claim 15, wherein said biodegradable polyol comprising at least one moiety derived from a polycaprolactone polyol is selected from poly (caprolactone-co-glycolide) polyol, poly (caprolactone-co-l-lactide) polyol, poly (caprolactone-co-d-l-lactide) polyol, poly (caprolactone-co-para-dioxanone) polyol, (caprolactone-co-l-lactide-co glycolide) polyol, poly (caprolactone-co-glycolide-co-d-l lactide) polyol, poly (caprolactone-co-ethylene glycol) polyol, poly (caprolactone-co-saccharide) polyol, and mixtures thereof.

17. A medical device comprising the matrix of claim 1.

18. The matrix of claim 1, wherein said matrix comprises a plurality of interconnected pores forming a continuous intercommunicating network of voids.

19. The matrix of claim 18, wherein the continuous intercommunicating network of voids extends from an interior portion to an exterior surface of said matrix.

20. The matrix of claim 1, wherein at least about 40% of cell walls of said matrix is removed.

21. The matrix of claim 1, wherein at least about 65% of cell walls of said matrix is removed.

22. The matrix of claim 1, wherein at least about 80% of cell walls of said matrix is removed.

23. The matrix of claim 1, wherein at least about 90% of cell walls of said matrix is removed.

24. The matrix of claim 1, wherein said matrix is thermally reticulated.

25. The matrix of claim 1, wherein the continuous-interconnected void phase exists before implantation into the human body.

26. The matrix of claim 1, wherein an average number of isocyanate groups per molecule in the isocyanate-derived hard segment is about 2.

27. The matrix of claim 1, wherein an average number of isocyanate groups per molecule in the isocyanate-derived hard segment is greater than about 2.

28. A matrix comprising a biocompatible, cross-linked, biodegradable, elastomeric polyurethane, the matrix having a continuous-interconnected void phase, wherein the matrix is configured to be implantable in a human body and to support a biological tissue in-growth, wherein the matrix comprises a biodegradable, polyol-derived soft segment and an isocyanate-derived hard segment, and wherein said matrix is reticulated, wherein said isocyanate hard segment is substantially non-crystalline;

wherein a path through the void phase can be drawn in a substantially linear direction across an entirely of said matrix beginning at any portion of an exterior surface of said matrix containing said void phase.