Electrochemical potentiometric sensing without reference electrode
First Claim
1. An electrochemical sensor for determining a charged particle concentration in an analyte, the electrochemical sensor comprising:
- a first electrode with a first ion-sensitive dielectric provided thereon, the first electrode being configured to contact the analyte via the first ion-sensitive dielectric to obtain a first interface between the first ion-sensitive dielectric and the analyte, wherein the first ion-sensitive dielectric is further provided with a probe molecule layer comprising probe molecules;
a second electrode with a second ion-sensitive dielectric provided thereon, the second electrode being configured to contact the analyte via the second ion-sensitive dielectric to obtain a second interface between the second ion-sensitive dielectric and the analyte, anda controller configured to measure a potential difference between the first electrode and the second electrode using at least two different values of a temperature difference between the first interface and the second interface to obtain at least two measurement points of a surface-potential versus interface-temperature curve.
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Abstract
The invention relates to a method of determining a charged particle concentration in an analyte (100), the method comprising steps of: i) determining at least two measurement points of a surface-potential versus interface-temperature curve (c1, c2, c3, c4), wherein the interface temperature is obtained from a temperature difference between a first interface between a first ion-sensitive dielectric (Fsd) and the analyte (100) and a second interface between a second ion-sensitive dielectric (Ssd) and the analyte (100), and wherein the surface-potential is obtained from a potential difference between a first electrode (Fe) and a second electrode (Se) onto which said first ion-sensitive dielectric (Fsd) and said second ion-sensitive dielectric (Ssd) are respectively provided, And ii) calculating the charged particle concentration from locations of the at least two measurement points of said curve (c1, c2, c3, c4). This method, which still is a potentiometric electrochemical measurement, exploits the temperature dependency of a surface-potential of an ion-sensitive dielectric in an analyte. The invention further provides an electrochemical sensor for determining a charged particle concentration in an analyte. The invention also provides various sensors which can be used to determine the charged particle concentration, i.e. EGFET'"'"'s and EIS capacitors.
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Citations
22 Claims
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1. An electrochemical sensor for determining a charged particle concentration in an analyte, the electrochemical sensor comprising:
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a first electrode with a first ion-sensitive dielectric provided thereon, the first electrode being configured to contact the analyte via the first ion-sensitive dielectric to obtain a first interface between the first ion-sensitive dielectric and the analyte, wherein the first ion-sensitive dielectric is further provided with a probe molecule layer comprising probe molecules; a second electrode with a second ion-sensitive dielectric provided thereon, the second electrode being configured to contact the analyte via the second ion-sensitive dielectric to obtain a second interface between the second ion-sensitive dielectric and the analyte, and a controller configured to measure a potential difference between the first electrode and the second electrode using at least two different values of a temperature difference between the first interface and the second interface to obtain at least two measurement points of a surface-potential versus interface-temperature curve. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of determining a charged particle concentration in an analyte, the method comprising:
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determining at least two measurement points of a surface-potential versus interface-temperature curve, wherein the interface temperature is obtained from a temperature difference between a first interface between a first ion-sensitive dielectric and the analyte and a second interface between a second ion-sensitive dielectric and the analyte, and the surface-potential is obtained from a potential difference between a first electrode and a second electrode onto which said first ion-sensitive dielectric and said second ion-sensitive dielectric are respectively provided; and calculating the charged particle concentration from locations of the at least two measurement points of said curve. - View Dependent Claims (22)
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Specification