Inhibitors of fatty acid amide hydrolase
First Claim
1. A method of treating an FAAH-mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I:
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Accused Products
Abstract
Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z1, Z2, X1, X2, X3, R1, R2 R3, R4, m and n are defined herein. Also provided are pharmaceutically acceptable compositions that include a compound of formula I and a pharmaceutically acceptable excipient. Also provided are methods for treating an FAAH-mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound or composition of the present invention.
103 Citations
53 Claims
- 1. A method of treating an FAAH-mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I:
- 42. The method of 41, wherein the pain disorder is selected from neuropathic pain, central pain, deafferentiation pain, chronic pain, stimulus of nociceptive receptors, acute pain, non-inflammatory pain, inflammatory pain, pain associated with cancer, preoperative pain, arthritic pain, lumbosacral pain, musculo-skeletal pain, headache, migraine, muscle ache, lower back and neck pain, and toothache.
Specification