Devices and methods for delivering active agents to the osteomeatal complex

• US 8,802,131 B2
• Filed: 08/14/2009
• Issued: 08/12/2014
• Est. Priority Date: 07/10/2006
• Status: Active Grant

• Current Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Original Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Inventors: Arensdorf, Patrick A., Biggs, Danielle L., Brenneman, Rodney, Downie, David B., Eaton, Donald J., Tice, Thomas R.
• Primary Examiner(s): Long, Scott
• Assistant Examiner(s): BECKHARDT, LYNDSEY MARIE
• Application Number:
  US12/541,840
• Publication Number:
  US 20090306624A1
• Time in Patent Office: 1,824 Days
• Field of Search: None
• US Class Current: 424/434
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.

Claims

1. A method for cannulating a portion of an osteomeatal complex comprising:

implanting and securing a portion of a cannulating device to the osteomeatal complex by piercing a portion of the osteomeatal complex with a pointed tip of the cannulating device, wherein the cannulating device comprises a lumen extending at least partially therethrough and wherein the pointed tip of the cannulating device is implanted.

2. The method of claim 1 wherein the cannulating device is configured to release one or more active agents.

3. The method of claim 2 wherein the one or more active agents comprises an anti-inflammatory agent.

4. The method of claim 3 wherein the anti-inflammatory agent comprises mometasone furoate.

5. The method of claim 3 wherein the anti-inflammatory agent comprises fluticasone propionate.

6. The method of claim 1 wherein the cannulating device comprises a polymer coating.

7. The method of claim 6 wherein the polymer coating comprises one or more active agents.

8. The method of claim 1 wherein the cannulating device comprises a biodegradable polymer.

9. The method of claim 8 wherein the biodegradable polymer comprises a lactide/glycolide polymer.

10. The method of claim 1 wherein piercing the portion of the osteomeatal complex comprises piercing an ethmoid bulla.

11. The method of claim 1 wherein piercing the portion of the osteomeatal complex comprises piercing an anterior ethmoid cell.

12. The method of claim 1 wherein the cannulating device comprises a plurality of openings in a side of the cannulating device, wherein the openings are connected to the lumen.

13. The method of claim 1 wherein piercing a portion of the osteomeatal complex comprises piercing an ethmoid bulla and a septum between the ethmoid bulla and an anterior ethmoid cell to create a channel between the ethmoid bulla and the anterior ethmoid cell.