Herbal composition and method of use for the treatment of cancer

• US 8,802,161 B2
• Filed: 01/30/2010
• Issued: 08/12/2014
• Est. Priority Date: 08/02/2003
• Status: Active Grant

• Current Assignee: Florida Agricultural and Mechanical University (State University System of Florida)
• Original Assignee: Florida Agricultural and Mechanical University (State University System of Florida)
• Inventors: Mazzio, Elizabeth Anne, Soliman, Karam F
• Primary Examiner(s): Orwig, Kevin S
• Application Number:
  US12/657,903
• Publication Number:
  US 20100209388A1
• Time in Patent Office: 1,655 Days
• Field of Search: None
• US Class Current: 424/725
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 35/748 Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina algae, microalgae or microphytes A61K36/02
• CPC Class Codes: A61K 36/00 Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines antigens from pollen A61K39/36
• CPC Class Codes: A61K 36/236 Ligusticum (licorice-root)
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/324 Boswellia, e.g. frankincense
• CPC Class Codes: A61K 36/328 Commiphora, e.g. mecca myrrh or balm of Gilead
• CPC Class Codes: A61K 36/484 Glycyrrhiza (licorice)
• CPC Class Codes: A61K 36/537 Salvia (sage)
• CPC Class Codes: A61K 36/54 Lauraceae (Laurel family), e.g. cinnamon or sassafras
• CPC Class Codes: A61K 36/704 Polygonum, e.g. knotweed
• CPC Class Codes: A61K 36/71 Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
• CPC Class Codes: A61K 36/8945 Dioscorea, e.g. yam, Chinese yam or water yam
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia

Abstract

The invention describes a nutraceutical composition and method for preventing/treating cancer or augmenting chemotherapy in advanced stage malignancies; comprised of [1] tumoricidal herbs; beth root, galbanum, gromwell root, wild yam, balm of gilead bud, frankincense, [2] an antiproliferative herb; speranskia [3] a natural lactic acid dehydrogenase (LDH) inhibitor, 2′,3,4′5,7-pentahydroxyflavone or cinnamon, [4] alkalizing agents: calcium, magnesium, potassium or bicarbonate salts, barley grass, chlorella and spirulina [5] at least one quinone and [6] at least one agent capable of maximizing oxidative mitochondrial function preferably riboflavin, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin and a pharmaceutically acceptable carrier.

Claims

1. A pharmaceutical composition useful for treating or reducing the risk of cancer comprising:

a) frankincense (Boswellia carteri)

b) at least one tumoricidal agent selected from the group consisting of beth root (Trillium pendulumroot), galbanum (Ferula galbaniflua), and wild yam (Dioscorea villosa),

c) at least one anti-proliferative herb comprising speranskia herb (Speranskia tuberculata) and;

d) at least one lactic acid dehydrogenase inhibitor herein termed “

LDH (−

)”

comprising at least one of cinnamon (Cinnamomum cassia) or 2′

,3,4′

,5,7-pentahydroxyflavone (morin), and

e) a pharmaceutically acceptable carrier

wherein the total amount of component a) is 5-20% by wt of the total composition, the total amount of component b) is 5-20% by wt of the total composition, and wherein component c) is present in a total amount of up to 8% by wt of the total composition.

2. The composition according to claim 1, wherein said pharmaceutically acceptable carrier comprises one or more selected from the group consisting of water, saline, starches, sugars, gels, lipids, waxes, glycerol, solvents, oils, liquids, proteins, glycols, electrolyte solutions, alcohols, stabilizers, fillers, binders, emulsifiers, humectants, preservatives, buffers, colorants, emollients, foaming agents, sweeteners, thickeners, surfactants, additives, solvents, and mixtures thereof.

3. The composition according to claim 2, wherein said pharmaceutically acceptable carrier is suitable for oral, external, or injectable administration and is in the form of a solid, liquid, powder, paste, gel, tablet, granule, foam, pack, aerosol, solvent, diluent, capsule, pill, drink, tea, liposome, syrup, solution, suppository, emulsion, enema, suspension, dispersion, food, or mixtures thereof.

4. The composition according to claim 1 wherein the total amount of said LDH (−

) is 5-15% by wt of the total composition.

5. The composition of claim 1 wherein said LDH (−

) further comprises one or more selected from the group consisting of gromwell root (Lithospermum erythrorhizon root), epigallocatechin gallate, quercetin, rosemary (Rosmarinus officinalis), citric acid, black walnut (Juglans nigra), clove (Syzygium aromaticum), nutmeg (Myristica fragans), licorice root (Glycyrrhiza glabra), coriander (Coriandrum sativum), ginger root (Zingiber officinale), myrrh gum (Commiphora molmol), and green tea (Camellia sinensis).

6. The composition of claim 1 wherein said tumoricidal agent further comprise one or more selected from the group consisting of teasel root (Dipsacus asper), bakuchi seed (Cyamopsis psoralioides), kanta kari (Solanum xanthocarpum), bushy knotweed rhizome (Polygonum cuspidatum), garcinia fruit (Garcinia cambogia), white sage (Salvia apiana), balm of gilead bud (Populus balsamifera), gambogic acid, and diosmin.

7. A method of inhibiting metastasis of cancer in a host, the method comprising administering to a host in need of cancer treatment an amount of the composition of claim 1 effective to inhibit metastasis of the cancer.