Methods of using human milk oligosaccharides for improving airway respiratory health

• US 8,802,650 B2
• Filed: 12/22/2011
• Issued: 08/12/2014
• Est. Priority Date: 12/31/2010
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Buck, Rachael, Duska-McEwen, Geralyn O., Davis, Steven R.
• Primary Examiner(s): Peselev, Elli
• Application Number:
  US13/335,433
• Publication Number:
  US 20120172331A1
• Time in Patent Office: 964 Days
• Field of Search: 514/53
• US Class Current: 514/53
• CPC Class Codes: A23C 9/206 Colostrum; Human milk
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A23V 2250/282 Oligosaccharides, digestible
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 31/716 Glucans
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants

Abstract

Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to preterm infants, term infants, toddlers, and children for improving airway defense mechanisms.

Claims

1. A method of improving airway respiratory health in an infant, toddler, or child in need thereof, the method comprising administering to the infant, toddler, or child a composition comprising the human milk oligosaccharide 2′

-fucosyllactose in a concentration of from about 0.001 mg/mL to about 0.2 mg/mL and a carotenoid in a concentration of from about 0.1 μ

g/mL to about 10 μ

g/mL.

2. The method of claim 1, wherein the carotenoid is lycopene.

3. The method of claim 1, wherein the carotenoid is present in a concentration of from about 0.1 μ

g/mL to about 1.5 μ

g/mL.

4. The method of claim 1, wherein the composition further comprises 6′

-sialyllactose.

5. The method of claim 4, wherein the composition further comprises 3′

-sialyllactose.

6. The method of claim 1, wherein the composition further comprises 3′

-sialyllactose and wherein the carotenoid is lycopene.

7. The method of claim 6, wherein the lycopene is present in a concentration of from about 4 μ

g/mL to about 6 μ

g/mL.

8. A method of improving airway defense mechanisms in an infant, toddler, or child in need thereof, the method comprising administering to the infant, toddler, or child a composition comprising the human milk oligosaccharide 2′

fucosyllactose in a concentration of from about 0.001 mg/mL to about 0.2 mg/mL and a carotenoid in a concentration of from about 0.1 μ

g/mL to about 10 μ

g/mL.

9. The method of claim 8, wherein the carotenoid is lycopene.

10. The method of claim 8, wherein the carotenoid is present in a concentration of from about 0.1 μ

g/mL to about 1.5 μ

g/mL.

11. The method of claim 8, wherein the composition further comprises 6′

-sialyllactose.

12. The method of claim 11, wherein the composition further comprises 3′

-sialyllactose.

13. The method of claim 8, wherein the composition further comprises 3′

sialyllactose and wherein the carotenoid is lycopene.

14. The method of claim 13, wherein the lycopene is present in a concentration of from about 4 μ

g/mL to about 6 μ

g/mL.