Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device
First Claim
1. A system comprising:
- a prediction criteria module, adapted to store information about one or more chronobiological rhythm prediction criteria;
a physiological information collection device, adapted to sense or receive infbrmation about at least one physiological process having a chronobiological rhythm whose presence, absence, or change is statistically associated with a disease state;
an impending disease state prediction module, coupled to the prediction criteria module to receive the one or more chronobiological rhythm prediction criteria and coupled to the physiological information collection device to receive the chronobiological rhythm of the at least one physiological process, the impending disease state prediction module being adapted to predict an occurrence of impending disease using the one or more chronobiological rhythm prediction criteria and the chronobiological rhythm of the at least one physiological process; and
a therapy control module adapted to adjust or initiate a therapy using the predicted occurrence of impending disease, wherein the system is configured to monitor the efficacy of the therapy and to adjust the therapy to prevent or minimize the impending disease state.
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Abstract
The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
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Citations
13 Claims
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1. A system comprising:
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a prediction criteria module, adapted to store information about one or more chronobiological rhythm prediction criteria; a physiological information collection device, adapted to sense or receive infbrmation about at least one physiological process having a chronobiological rhythm whose presence, absence, or change is statistically associated with a disease state; an impending disease state prediction module, coupled to the prediction criteria module to receive the one or more chronobiological rhythm prediction criteria and coupled to the physiological information collection device to receive the chronobiological rhythm of the at least one physiological process, the impending disease state prediction module being adapted to predict an occurrence of impending disease using the one or more chronobiological rhythm prediction criteria and the chronobiological rhythm of the at least one physiological process; and a therapy control module adapted to adjust or initiate a therapy using the predicted occurrence of impending disease, wherein the system is configured to monitor the efficacy of the therapy and to adjust the therapy to prevent or minimize the impending disease state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification