Method and apparatus for optimizing electrical stimulation parameters using heart rate variability

• US 8,805,503 B2
• Filed: 02/03/2010
• Issued: 08/12/2014
• Est. Priority Date: 01/18/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Pastore, Joseph M., Salo, Rodney W., Carlson, Gerrard M., Kramer, Andrew P., Ding, Jiang, Yu, Yinghong
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US12/699,457
• Publication Number:
  US 20100137932A1
• Time in Patent Office: 1,651 Days
• Field of Search: 600/519, 600/510, 607/9, 607/15, 607/17, 607 27- 28
• US Class Current: 607/17
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient'"'"'s cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value.

Claims

1. A method comprising:

starting a stimulation parameter optimization period on a periodic basis;

sensing a cardiac signal;

measuring a heart rate;

producing a plurality of parameter values for at least one stimulation parameter based on the measured heart rate, the plurality of parameter values to be tested during the stimulation parameter optimization period;

delivering a plurality of series of test pulses of electrical stimulation pulses using the at least one stimulation parameter during the stimulation parameter optimization period, each series of test pulses of the plurality of series of test pulses associated with a parameter value of the plurality of parameter values for the at least one stimulation parameter;

measuring a heart rate variability (HRV) being a variance in cardiac cycle lengths over a predetermined period of time to produce at least one HRV parameter being a measure of the HRV based on the cardiac signal sensed during the stimulation parameter optimization period; and

selecting an approximately optimal value for the at least one stimulation parameter from the plurality of parameter values, the approximately optimal value corresponding to a maximum value of the HRV parameter measured during the stimulation parameter optimization period.

2. The method of claim 1, further comprising programming the stimulation parameter optimization period for a period associated with low physical activity level.

3. The method of claim 1, wherein measuring the heart rate comprises measuring a dynamically changing heart rate, producing the plurality of parameter values comprises dynamically producing values of a dynamic stimulation parameter based on the dynamically changing heart rate during the stimulation parameter optimization period, delivering the electrical stimulation pulses comprises delivering stimulation pulses using the values of the dynamic stimulation parameter during the stimulation parameter optimization period, and selecting the approximately optimal value for the at least one stimulation parameter including comprises selecting the approximately optimal value from the values of the dynamic stimulation parameter produced during the stimulation parameter optimization period, the approximately optimal value corresponding to a maximum value of the HRV parameter measured for the stimulation parameter optimization period.

4. The method of claim 1, wherein delivering the plurality of series of test pulses of electrical stimulation pulses comprises delivering pacing pulses.

5. The method of claim 4, wherein delivering pacing pulses comprises delivering the pacing pulses by executing a pacing algorithm during the stimulation parameter optimization period, the pacing algorithm using the at least one stimulation parameter.

6. The method of claim 5, wherein executing the pacing algorithm comprises executing at least one of a bradycardia pacing algorithm, a cardiac resynchronization therapy (CRT) pacing algorithm and a remodeling control therapy (RCT) pacing algorithm.

7. The method of claim 6, wherein the at least one stimulation parameter comprises an atrioventricular delay (AVD).

8. The method of claim 7, wherein the at least one stimulation parameter comprises an interventricular delay (IVD).

9. The method of claim 7, wherein the at least one stimulation parameter comprises a pacing site parameter identifying sites to which the pacing pulses are delivered.

10. The method of claim 1, wherein delivering the plurality of series of test pulses of electrical stimulation pulses comprises delivering neurostimulation pulses.

11. The method of claim 10, wherein delivering neurostimulation pulses comprises delivering the neurostimulation pulses by executing a neurostimulation algorithm during the stimulation parameter optimization period, the neurostimulation algorithm using the at least one stimulation parameter.

12. The method of claim 11, wherein the at least one stimulation parameter comprises a stimulation frequency.

13. The method of claim 11, wherein the at least one stimulation parameter comprises a stimulation site parameter identifying sites to which the neurostimulation pulses are delivered.

14. The method of claim 10, wherein delivering the electrical stimulation pulses comprises delivering cardiac pacing and autonomic neurostimulation pulses.

15. The method of claim 1, wherein measuring the variance in cardiac cycle lengths over the predetermined period of time to produce the at least one HRV parameter comprises measuring the variance in cardiac cycle lengths over the predetermined period of time to produce a Standard Deviation of Normal-to-Normal intervals (SDNN).

16. The method of claim 1, wherein measuring the variance in cardiac cycle lengths over the predetermined period of time to produce the at least one HRV parameter comprises measuring the variance in cardiac cycle lengths over the predetermined period of time to produce a Standard Deviation of Averages of Normal-to-Normal intervals (SDANN).

17. The method of claim 1, wherein measuring the variance in cardiac cycle lengths over the predetermined period of time to produce the at least one HRV parameter comprises measuring the variance in cardiac cycle lengths over the predetermined period of time to produce an HRV footprint.

18. The method of claim 1, wherein measuring the variance in cardiac cycle lengths over the predetermined period of time to produce the at least one HRV parameter comprises measuring the variance in cardiac cycle lengths over the predetermined period of time to produce a Root-Mean-Square of Successive Differences (RMSSD).

19. The method of claim 1, wherein measuring the variance in cardiac cycle lengths over the predetermined period of time to produce the at least one HRV parameter comprises measuring the variance in cardiac cycle lengths over the predetermined period of time to produce a parameter indicative of a balance between sympathetic and parasympathetic activities.

20. The method of claim 1, wherein delivering the plurality of series of test pulses of electrical stimulation pulses comprises delivering temporally coordinated pacing and neurostimulation pulses.