System and method of wireless physiological signal integration

• US 8,808,229 B2
• Filed: 11/14/2008
• Issued: 08/19/2014
• Est. Priority Date: 11/27/2007
• Status: Active Grant

• Current Assignee: National Applied Research Laboratories (Government of The Republic of China)
• Original Assignee: National Applied Research Laboratories (Government of The Republic of China)
• Inventors: Yang, Yuh-Shyong, Lin, Ming-Yu, Tsai, Kuei-Shin, Chang, Wen-Ying, Lin, Chih-Heng, Wei, Jo-Fen
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): Snyder, Melissa A
• Application Number:
  US12/291,876
• Publication Number:
  US 20090137947A1
• Time in Patent Office: 2,104 Days
• Field of Search: 604 66- 67, 604/503
• US Class Current: 604/66
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/63 for local operation

Abstract

A system of a wireless physiological signal integration is provided. The system includes a wireless transmission sensor chip and a drug delivering system, wherein the wireless transmission sensor chip includes a sensor sensing a physiological signal of a patient, a signal conversion module converting the physiological signal into a converted signal, and a wireless transmission module wirelessly transmitting the converted signal, and the drug delivering system determines a dose of a drug and a timing for providing the drug according to the converted signal.

Claims

1. A system of a wireless physiological signal integration, comprising:

a wireless transmission sensor chip, comprising;

a sensor including a luminescent substance, a peroxidase, and a photodiode sensing a physiological signal of a patient, wherein the physiological signal includes a luminescence, and the peroxidase catalyzes a peroxide included in a sample obtained from the patient to react with the luminescent substance to generate the luminescence;

a signal conversion module converting the physiological signal into a converted signal; and

a wireless transmission module wirelessly transmitting the converted signal; and

a drug delivering system determining a dose of a drug and a timing for providing the drug according to the converted signal.

2. A system according to claim 1, wherein the wireless transmission sensor chip is a System-on-Chip.

3. A system according to claim 1, wherein the wireless transmission sensor chip is fabricated by an integrated circuit process, and the integrated circuit process is a CMOS process.

4. A system according to claim 1, wherein the wireless transmission sensor chip is one of an invasive chip implanted in the patient and a non-invasive chip fastened at an exterior of the patient.

5. A system according to claim 1, wherein the wireless transmission sensor chip further comprises a plurality of sensors for sensing a plurality of physiological signals.

6. A system according to claim 1, wherein the sensor further includes a charge-induced transistor, a field effect transistor, an organic thin film transistor, and an ion selective electrode.

7. A system according to claim 1, wherein the sensor further comprises a reacting substance encapsulated by a sol-gel.

8. A system according to claim 1, wherein the physiological signal is one selected from a group consisting of an electrical signal, a chemical signal and a physical signal.

9. A system according to claim 8, wherein the sensor converts the physiological signal into a current and transmits the current to the signal conversion module when the physiological signal is one of the chemical signal and the physical signal, and the signal conversion module converts the current into an analog voltage and further converts the analog voltage into the converted signal, wherein the converted signal is an analog voltage signal.

10. A system according to claim 8, wherein when the physiological signal is the electrical signal, the signal conversion module converts the electrical signal into an analog voltage and further converts the analog voltage into the converted signal, and the converted signal is an analog voltage signal.

11. A system according to claim 1, wherein the physiological signal is one selected from a group consisting of a drug concentration, a DNA, an RNA, a protein, an ion, a blood sugar, a blood oxygen, a physiological substance, a brain wave, an electrocardiogram signal, a blood pressure, a pulse rate, a body temperature, and a light signal.

12. A system according to claim 1, further comprising a power supply electrically connected to the wireless transmission sensor chip for providing a power thereto, wherein the power supply is a battery.

13. A system according to claim 1, wherein the drug delivering system further comprises a wireless signal receiving module for receiving the converted signal.

14. A system according to claim 1, wherein the drug delivering system provides the drug to the patient automatically.

15. A system according to claim 1, wherein the drug delivering system delivers the drug to a body part of the patient.