Methods and apparatus for pulsatile release of medicaments from a punctal plug
First Claim
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1. A pulsatile delivery device of an active agent, the device comprising:
- a tube inserted into a cavity of a punctal plug; and
two or more discrete pulsatile delivery units arranged in a generally linear fashion within the tube, wherein the two or more discrete pulsatile delivery units comprise a core comprising the active agent and an encapsulation layer surrounding the core, the discrete pulsatile delivery units are spaced apart from one another and in a generally linear arrangement are arranged to release from the tube multiple pulses of active agent, wherein each respective pulse of active agent comprises a generally equal volume of active agent and each respective pulse of active agent comprises a generally equal concentration of active agent.
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Abstract
This invention discloses methods and apparatus for providing pulsatile release of active agents via a punctal plug inserted into a punctum. A tube is provided which may be inserted into a cavity of a punctal plug. One or more pulsatile delivery units are arranged in a generally linear fashion within the tube. The pulsatile delivery units include a core comprising the active agent and an encapsulation layer around the core.
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18 Claims
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1. A pulsatile delivery device of an active agent, the device comprising:
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a tube inserted into a cavity of a punctal plug; and two or more discrete pulsatile delivery units arranged in a generally linear fashion within the tube, wherein the two or more discrete pulsatile delivery units comprise a core comprising the active agent and an encapsulation layer surrounding the core, the discrete pulsatile delivery units are spaced apart from one another and in a generally linear arrangement are arranged to release from the tube multiple pulses of active agent, wherein each respective pulse of active agent comprises a generally equal volume of active agent and each respective pulse of active agent comprises a generally equal concentration of active agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification