Nanoshell therapy

• US 8,808,342 B2
• Filed: 04/23/2013
• Issued: 08/19/2014
• Est. Priority Date: 06/14/2006
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Ludwig, Florian Niklas
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): SAMALA, JAGADISHWAR RAO
• Application Number:
  US13/868,956
• Publication Number:
  US 20130317579A1
• Time in Patent Office: 483 Days
• Field of Search: 424/1.61, 424/130.1, 424/422, 424/423, 424/489, 424/490, 607/7, 607/8, 607/10, 607 13- 17, 607/20, 607 88- 96
• US Class Current: 607/88
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052
• CPC Class Codes: A61N 5/00 Radiation therapy ultrasound therapy A61N7/00; devices or apparatus applicable to both therapy and diagnosis A61B6/00
• CPC Class Codes: Y10T 428/249924 Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity
• CPC Class Codes: Y10T 428/2991 Coated

Abstract

Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a vascular condition are provided.

Claims

1. A method of treating or ameliorating a vascular condition, comprising:

(a) administering to a subject nano-constructs capable of absorbing energy from an electromagnetic radiation or energy from a fluctuating electromagnetic field and translating the energy into heat,

(b) causing the nano-constructs to reach a target tissue wherein the nano-constructs reach the target tissue by extravasation through leaky vasculature in the target tissue or by targeting molecules on the surface of the nano-constructs that have affinity for the target tissue, and

(c) applying an energy to the nano-constructs to cause the nano-constructs to heat the target tissue,

wherein the nano-construct comprises a core material and a carbon or conducting polymer nanoshell formed on the core material.

2. The method of claim 1, wherein the causing comprises allowing the nano-constructs to extravasate through leaky vasculature in the target tissue.

3. The method of claim 2, wherein the nano-constructs comprise a surface-stealthing compound on the surface of the nano-constructs such that the circulation time of the nano-constructs is increased.

4. The method of claim 3, wherein the surface-stealthing compound is poly(ethylene glycol).

5. The method of claim 1, wherein the nano-constructs comprise targeting molecules on the surface of the nano-constructs.

6. The method of claim 5, wherein the targeting molecules are surface-conjugated ligands against receptors on an inflamed endothelium.

7. The method of claim 5, wherein the targeting molecules are selected from the group consisting of a peptide, antibody, and polysaccharide with affinity to the target site.

8. The method of claim 5, wherein the targeting molecules are selected from the group consisting of antibodies to CD34, RGD, YIGSR, peptides and antibodies to IIbIIIa, heparin, hyaluronic acid, laminin, collagen, ICAM-1, ICAM-2, ICAM-3, fibrinogen, fibronectin, vitronectin, thrombospondin, osteopontin, integrins, VCAM-1, N-CAM, PECAM-1, IgCAM, folate, oligonucleotide aptamers, selectins, cadherins.

9. The method of claim 5, wherein the targeting molecules are attached to the nanoshell via a spacer.

10. The method of claim 9, wherein the spacer is selected from the group consisting of a C₁-C₂₀ alkyl, a C₃-C₂₀ cycloalkyl, poly(ethylene glycol), poly(alkylene oxide), dextran, dextrose, heparin, poly(propylene sulfide), hyaluronic acid, peptides, DNA, PVA, and PVP.

11. The method of claim 1, wherein the energy is a near infrared (NIR) electromagnetic radiation applied through a catheter-based fiber-optic.

12. The method of claim 1, wherein the energy is from electromagnetic irradiation applied outside the body of the subject.

13. The method of claim 1, wherein the nanoshell comprises a metal.

14. The method of claim 1, wherein the nanoshell comprises gold.

15. The method of claim 1, wherein the nanoshell has a thickness in the range between about 2 nm and about 100 nm.

16. The method of claim 1, wherein the vascular condition is selected from atherosclerotic plaque, vulnerable plaque, diffuse atherosclerotic disease, diabetic retinopathy, aneurysm, anastomotic hyperplasia, claudication, chronic total occlusion, dysfunctional endothelium, recurring thrombus, fibrin accumulation, or combinations of these.

17. The method of claim 16, wherein the atherosclerotic plaque is located by imaging by interrogation with an attenuated radiation.

18. The method of claim 1, wherein the administering is achieved through a catheter.

19. The method of claim 1, wherein the conducting polymer is selected from the group consisting of poly(pyrrole), poly(thiophene), poly(acetylene), poly(aniline), graphite, carbon nanotubes, DNA, and combinations thereof.

20. The method of claim 1, wherein the core material is selected from the group consisting of silicon oxide, silica, aluminum oxide, biopolymers, a polymer, or a combination thereof.

21. The method of claim 1, wherein the nanoshell comprises carbon.

22. The method of claim 1, wherein the nanoshell comprises a conducting polymer.