System and method for providing a graft in a vascular environment

• US 8,808,362 B2
• Filed: 04/08/2010
• Issued: 08/19/2014
• Est. Priority Date: 07/07/2006
• Status: Active Grant

• Current Assignee: Graft Technologies, Inc.
• Original Assignee: Graft Technologies, Inc.
• Inventors: Anwar, Azam, Feghali, Georges A., Johnson, Kenneth B.
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US12/756,361
• Publication Number:
  US 20100191322A1
• Time in Patent Office: 1,594 Days
• Field of Search: 623 111- 148
• US Class Current: 623/1.36
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 2017/1107 for blood vessels
• CPC Class Codes: A61B 2017/1135 End-to-side connections, e.g. T- or Y-connections Y-shaped blood vessel prostheses A61F2002/065
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching

Abstract

An apparatus is provided that includes a graft for coupling two vascular conduits within a patient. The graft includes: 1) an anchor system that forms an arc at one end of the conduits; and 2) a body element coupled to the anchor system. The anchor system comprises a biodegradable stent. In particular embodiments, portions of the graft are either self-expandable or balloon-expandable. In still other embodiments, anchor system includes NITINOL and the anchor system is substantially self-sealing at one end of the conduits. In one embodiment, the body element comprises polytetrafluoroethylene (PTFE) or expanded polytetrafluoroethylene (EPTFE). In yet other embodiments, the body element includes either a gelatinous or an elastomeric coating disposed on its surface.

Claims

1. An apparatus, comprising:

a graft for coupling two vascular conduits, wherein the graft includes;

a curved anchor system having an expandable end adapted to be coaxially received within one of the conduits such that the expandable end applies a resistive force to the one conduit when the expandable end is radially expanded to have a greater inner dimension; and

a body element coupled to the curved anchor system, wherein the anchor system forms an arc at an opening of the one conduit such that the body element is angled outwardly from the opening, and wherein the curved anchor system is substantially self-sealing at the one conduit, wherein an abrasive material of the anchor system provides a frictional resistive force to inhibit movement of the anchor system relative to the one conduit when the anchor system is radially expanded within the one conduit, wherein the anchor system comprises a biodegradable stent, wherein a delivery system is used to deliver the graft to a target location, wherein the delivery system includes a plunger and a base that is coupled to the plunger, wherein actuation of the plunger can cause the graft to be released.

2. The apparatus of claim 1, wherein the body element and the curved anchor system are integrally formed.

3. The apparatus of claim 1, wherein the body element is at least partially biodegradable.

4. The apparatus of claim 1, wherein the stent includes a drug, which covers either an external or an internal surface of the stent.

5. The apparatus of claim 1, wherein the covers the curved anchor system and the body element.

6. The apparatus of claim 1, wherein the expandable end of the curved anchor system is either self-expandable or balloon-expandable.

7. The apparatus of claim 1, wherein the graft includes internal scaffolding to provide reinforcement to the graft.

8. The apparatus of claim 1, wherein the body element or the curved anchor system includes a coating, a fibrous material, or a wrap that can be used for drug loading.

9. The apparatus of claim 8, wherein the curved anchor system is drug eluting.

21. The apparatus of claim 1, wherein the abrasive material is one of a coating on the anchor system or a structure of the anchor system.

10. An apparatus, comprising:

a graft for coupling two vascular conduits, wherein the graft includes;

a curved anchor system forming an arc at an opening of the conduits, the curved anchor system including an expandable end; and

a body element integrally formed with the curved anchor system into a continuous piece,

wherein when the expandable end is positioned through an opening of one conduit with at least a portion of the anchor system coaxially aligned with the one conduit and with the expandable end radially expanded therein, the expandable end applies a resistive force to the one conduit and the body element is in fluid communication with the one conduit without needing sutures at the opening, wherein the anchor system comprises a biodegradable stent, wherein a delivery system is used to deliver the graft to a target location, wherein the delivery system includes a plunger and a base that is coupled to the plunger, wherein actuation of the plunger can cause the graft to be released.

11. The apparatus of claim 10, wherein the body element is angled outwardly from the opening of the one conduit.

12. The apparatus of claim 11, wherein the curved anchor system is substantially self-sealing at the one conduit.

13. The apparatus of claim 10, wherein the graft further includes an outer cover surrounding the curved anchor system.

14. The apparatus of claim 13, wherein the outer cover is adapted to deliver drug therapy to the one conduit.

15. The apparatus of claim 13, further comprising:

an inner cover opposing the outer cover and defining a space therebetween sized to receive the stent.

16. The apparatus of claim 15, wherein the inner cover is adapted to deliver drug therapy to the one conduit.

17. The apparatus of claim 10, further comprising:

an expandable stent extending along the body element.

18. The apparatus of claim 10, wherein the curved anchor system is substantially self-sealing at the one conduit.

19. An apparatus, comprising:

a graft for coupling two vascular conduits within a patient, wherein the graft includes;

an anchor system that forms an arc at an opening of one end of the conduits;

a body element coupled to the anchor system, wherein the anchor system comprises a biodegradable stent;

a delivery system used to deliver the graft to a target location, wherein the delivery system includes a plunger and a base that is coupled to the plunger, wherein actuation of the plunger can cause the graft to be released.

20. The apparatus of claim 19, wherein the delivery system further includes a perforated splittable sheath.