Electrode compositions for use with analyte sensors
First Claim
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1. A method of making a sensor apparatus for implantation within a mammal comprising the steps of:
- providing a base layer;
forming a conductive layer on the base layer, wherein the conductive layer includes a working electrode formed from a sputtered platinum composition;
forming an electrolyte retaining layer in operable contact with the conductive layer,wherein the electrolyte retaining layer is formed from a composition selected to absorb 10% 10 to 50% water by weight;
forming an analyte sensing layer disposed over the conductive layer, wherein the analyte sensing layer comprises glucose oxidase entrapped within a poly(vinyl alcohol)-styrylpyridinium (PVA-SbQ) polymer matrix; and
forming an analyte modulating layer disposed over the analyte sensing layer, wherein the method comprises modifying a surface of the analyte sensing layer using a plasma deposition process so that chemical moieties on the surface are crosslinked.
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Abstract
Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
36 Citations
7 Claims
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1. A method of making a sensor apparatus for implantation within a mammal comprising the steps of:
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providing a base layer; forming a conductive layer on the base layer, wherein the conductive layer includes a working electrode formed from a sputtered platinum composition; forming an electrolyte retaining layer in operable contact with the conductive layer, wherein the electrolyte retaining layer is formed from a composition selected to absorb 10% 10 to 50% water by weight; forming an analyte sensing layer disposed over the conductive layer, wherein the analyte sensing layer comprises glucose oxidase entrapped within a poly(vinyl alcohol)-styrylpyridinium (PVA-SbQ) polymer matrix; and forming an analyte modulating layer disposed over the analyte sensing layer, wherein the method comprises modifying a surface of the analyte sensing layer using a plasma deposition process so that chemical moieties on the surface are crosslinked. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A composition of matter comprising:
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a sputtered platinum composition, wherein the sputtered platinum composition exhibits a root-mean-square roughness value below 3 nanometers; and hydrophilic polymer composition comprising; (a) crosslinked Poly(2-hydroxyethyl methacrylate) polymers having an average molecular weight between 100 and 1000 kilodaltons;
or(b) crosslinked primary amine polymers having an average molecular weight between 4 and 500 kilodaltons; (c) crosslinked poly(vinyl alcohol)-styrylpyridinium (PVA-SbQ) polymers; and (d) glucose oxidase.
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Specification