Bioerodible endoprostheses and methods of making the same

• US 8,808,726 B2
• Filed: 09/14/2007
• Issued: 08/19/2014
• Est. Priority Date: 09/15/2006
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Atanasoska, Liliana, Weber, Jan, Warner, Robert W., Grovender, Amy
• Primary Examiner(s): Barham, Bethany
• Assistant Examiner(s): AL-AWADI, DANAH J
• Application Number:
  US11/855,499
• Publication Number:
  US 20080183277A1
• Time in Patent Office: 2,531 Days
• Field of Search: None
• US Class Current: 424/426
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61L 2300/802 Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Bioerodible endoprostheses and methods of making the endoprostheses are disclosed. In some embodiments, an endoprosthesis includes a member including a bioerodible material, and an antioxidant carried by the member. Examples of antioxidants include phenols.

Claims

1. An endoprosthesis, comprising:

a member comprising a bioerodible material, wherein the bioerodible material is iron or magnesium; and

an antioxidant carried by the member, wherein the antioxidant is encapsulated by the bioerodible material.

3. The endoprosthesis of claim 1, wherein the antioxidant comprises a phenol.

4. The endoprosthesis of claim 1, wherein the member comprises a tubular member constructed to maintain patency of a body vessel.

5. The endoprosthesis of claim 1, further comprising a drug carried by the member.

6. The endoprosthesis of claim 1, in the form of a stent.

2. An endoprosthesis, comprising:

a member comprising a bioerodible material, wherein the bioerodible material is iron or magnesium and

an antioxidant within a matrix of the bioerodible material.

7. A method of making an endoprosthesis, the method comprising incorporating a bioerodible material with an antioxidant to form at least a portion of the endoprosthesis, wherein the bioerodible material is iron or magnesium and the antioxidant is encapsulated by the bioerodible material.

8. The method of claim 7, wherein the bioerodible material is in the form of a tubular member.

9. The method of claim 7, wherein the bioerodible material is in the form of a tubular member, and the antioxidant is incorporated in a select portion of the tubular member.

10. The method of claim 7, wherein the antioxidant is in a particle encapsulated by a bioerodible material.

11. The method of claim 10, wherein the particle comprises zinc oxide.

12. The method of claim 7, wherein the antioxidant comprises a phenol.

13. The method of claim 12, wherein the antioxidant is selected from the group consisting of eugenol, isoeugenol, and acetyl-eugenol.

14. The method of claim 7, wherein the portion is a tubular member constructed to maintain patency of a body vessel.

15. The method of claim 7, further comprising incorporating a drug with the portion.

16. The method of claim 7, wherein the endoprosthesis has the form of a stent.

17. The method of claim 7, wherein the bioerodible material is magnesium.