Surgical hydrogel

• US 8,809,301 B2
• Filed: 05/03/2013
• Issued: 08/19/2014
• Est. Priority Date: 08/28/2007
• Status: Active Grant

• Current Assignee: Robinson Squidgel, Ltd., Adelaide Research & Innovation Pty Ltd. (University of Adelaide), Otago Innovation Limited (University of Otago)
• Original Assignee: Robinson Squidgel, Ltd., Adelaide Research & Innovation Pty Ltd. (University of Adelaide), Otago Innovation Limited (University of Otago)
• Inventors: Athanasiadis, Theodore, Hanton, Lyall Robert, Moratti, Stephen Carl, Robinson, Brian Harford, Robinson, Simon Rae, Shi, Zheng, Simpson, James, Wormald, Peter John
• Primary Examiner(s): ZISKA, SUZANNE E
• Application Number:
  US13/886,659
• Publication Number:
  US 20130244974A1
• Time in Patent Office: 473 Days
• Field of Search: 514/55, 536/20
• US Class Current: 514/55
• CPC Class Codes: A61K 31/738 Cross-linked polysaccharides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 9/06 Antiarrhythmics
• CPC Class Codes: C08B 37/0063 Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

A composition suitable for use in wound healing, particularly for reducing post-surgical adhesions, containing cross-linked derivatives of chitosan and dextran polymers. A hydrogel forms when solutions of the polymers are combined.

Claims

1. A composition comprising a dicarboxy-derivatized chitosan polymer cross-linked to an aldehyde-derivatized dextran polymer.

2. A composition according to claim 1 wherein the dicarboxy-derivatized chitosan polymer is cross-linked to the aldehyde-derivatized dextran polymer through an amine group of the dicarboxy-derivatized chitosan polymer and an aldehyde group of the aldehyde-derivatized dextran polymer.

3. A composition according to claim 1 wherein the composition forms a hydrogel within about 1 sec to about 5 minutes of mixing the dicarboxy-derivatized chitosan polymer and the aldehyde-derivatized dextran polymer in aqueous solution.

4. A composition according to claim 3 wherein the composition forms a hydrogel within about 1 sec to about 30 sec of mixing the dicarboxy-derivatized chitosan polymer and the aldehyde-derivatized dextran polymer in aqueous solution.

5. A composition according to claim 1 wherein the dicarboxy-derivatized chitosan polymer is N-succinyl chitosan.

6. A composition according to claim 1 further comprising an aqueous solution.

7. A composition according to claim 6 containing between about 2% to 10% w/v dicarboxy-derivatized chitosan polymer and between about 2% to 10% w/v aldehyde-derivatized dextran polymer.

8. A composition according to claim 1 in the form of a hydrogel.

9. A composition according to claim 8 containing between about 2% to about 8% w/v dicarboxy-derivatized chitosan polymer and about 2% to about 8% w/v aldehyde-derivatized dextran polymer.

10. A composition according to claim 8 containing about 5% w/v dicarboxy-derivatized chitosan polymer and about 5% w/v aldehyde-derivatized dextran polymer.

11. A composition according to claim 1 further comprising one or more biologically active agents.

12. A composition according to claim 11 wherein said one or more biologically active agents are selected from the group consisting of plasma proteins, hormones, enzymes, antibiotics, antiseptic agents, antineoplastic agents, antifungal agents, antiviral agents, anti-inflammatory agents, growth factors, steroids, cell suspensions, cytotoxins, and cell proliferation inhibitors.

13. A wound dressing comprising a composition according to claim 1.

15. A method of preventing or reducing adhesion of tissue susceptible to adhesion formation comprising treating the tissue with a composition according to claim 1.

16. A method of accelerating or promoting wound healing comprising treating the wound with a composition according to claim 1.

17. A method of reducing or stopping bleeding of a wound comprising treating the wound with a composition of claim 1.

14. A method of producing a composition of a dicarboxy-derivatized chitosan polymer cross-linked to an aldehyde-derivatized dextran polymer, comprising mixing an aqueous solution of a dicarboxy-derivatized chitosan polymer with an aqueous solution of an aldehyde-derivatized dextran polymer.

18. A method of treating a tissue comprising applying to said tissue:

(a) an aqueous solution of a dicarboxy-derivatized chitosan polymer; and

(b) an aqueous solution of an aldehyde-derivatized dextran polymer, such that (a) and (b) combine to form a cross-linked composition on said tissue.

19. A kit comprising:

(a) dicarboxy-derivatized chitosan polymer, and

(b) an aldehyde-derivatized dextran polymer.