Methods of regulating actin cytoskeletal rearrangement and intercellular gap formation
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1. A method of reducing actin cytoskeletal rearrangement or intercellular gap formation in a cell, the method comprising contacting the cell during cold ischemia with an effective amount of a compound of Formula (I):
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Abstract
Methods are described for reducing cytoskeletal rearrangement and intercellular gap formation by contacting cells with an aminoalkyl glucosaminide phosphate. In particular, the methods can be used to reduce actin cytoskeletal rearrangement and/or intracellular gap formation related to ischemic or ischemia-reperfusion events and to alleviate diseases or conditions related to increased actin cytoskeletal rearrangement.
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15 Claims
- 1. A method of reducing actin cytoskeletal rearrangement or intercellular gap formation in a cell, the method comprising contacting the cell during cold ischemia with an effective amount of a compound of Formula (I):
- 10. A method of maintaining or preserving a transplantable extracorporeal tissue or organ by reducing actin cytoskeletal rearrangement and/or intercellular gap formation in one or more cells in the tissue or organ, the method comprising contacting the transplantable extracorporeal tissue or organ during cold ischemia with a supplementing solution comprising an effective amount of a compound of Formula (I):
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