Optimized Fc variants and methods for their generation
First Claim
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1. A variant Fc region of a human parent IgG1 Fc region, wherein said variant Fc region comprises an amino acid substitution in the human parent Fc region at position 264, wherein said variant Fc region exhibits altered binding affinity to an Fcγ
- receptor (Fcγ
R) as compared to a parent Fc region and wherein numbering is according to the EU index.
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Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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Citations
11 Claims
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1. A variant Fc region of a human parent IgG1 Fc region, wherein said variant Fc region comprises an amino acid substitution in the human parent Fc region at position 264, wherein said variant Fc region exhibits altered binding affinity to an Fcγ
- receptor (Fcγ
R) as compared to a parent Fc region and wherein numbering is according to the EU index. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- receptor (Fcγ
Specification