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Therapeutic compositions

  • US 8,809,516 B2
  • Filed: 09/25/2012
  • Issued: 08/19/2014
  • Est. Priority Date: 03/07/2003
  • Status: Active Grant
First Claim
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1. An iRNA agent, comprising:

  • a sense strand sequence having 4-12 asymmetrical 2′

    -O-alkyl modifications, at least 4 of which occur within the 6 terminal nucleotides of the 5′

    end; and

    an antisense sequence having at least 4 asymmetrical phosphorothioate modifications.

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