Therapeutic compositions
First Claim
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1. An iRNA agent, comprising:
- a sense strand sequence having 4-12 asymmetrical 2′
-O-alkyl modifications, at least 4 of which occur within the 6 terminal nucleotides of the 5′
end; and
an antisense sequence having at least 4 asymmetrical phosphorothioate modifications.
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Abstract
This application relates to therapeutic siRNA agents and methods of making and using the agents.
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Citations
22 Claims
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1. An iRNA agent, comprising:
- a sense strand sequence having 4-12 asymmetrical 2′
-O-alkyl modifications, at least 4 of which occur within the 6 terminal nucleotides of the 5′
end; and
an antisense sequence having at least 4 asymmetrical phosphorothioate modifications. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22)
- a sense strand sequence having 4-12 asymmetrical 2′
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21. An iRNA agent, comprising:
- a sense strand sequence having 4-12 asymmetrical 2′
-O-alkyl modifications, at least 4 of which occur within the 6 terminal nucleotides of the 3′
end; and
an antisense sequence having at least 4 asymmetrical phosphorothioate modifications.
- a sense strand sequence having 4-12 asymmetrical 2′
Specification