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Microarray reader based on evanescent wave detection

  • US 8,809,810 B2
  • Filed: 05/20/2010
  • Issued: 08/19/2014
  • Est. Priority Date: 05/20/2010
  • Status: Active Grant
First Claim
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1. A microarray reader, comprising:

  • a light source that emits light;

    beam shaping elements positioned near the light source to direct the light;

    a moving stage supporting the light source and beam shaping elements;

    a microarray that includes an optical substrate and a reaction chamber in contact with the optical substrate;

    a buffer solution encapsulated by the optical substrate and the reaction chamber;

    a holder that aligns the microarray relative to the light source such that when light hits the buffer solution certain molecules in the buffer solution are excited to emit fluorescent light;

    a temperature control component thermally engaged with the holder such that the temperature control component adjusts the temperature of the buffer solution;

    a sensor that receives the fluorescent light emitted by the excited molecules in the buffer solution to generate a signal;

    wherein the holder includes a first baffle that engages a first side of the microarray when the microarray is appropriately positioned within the holder;

    wherein the holder includes a second baffle that engages a second side of the microarray when the microarray is appropriately positioned within the holder; and

    wherein the holder includes a third baffle that engages a third side of the microarray when the microarray is appropriately positioned within the holder.

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