Transdermal analyte monitoring systems and methods for analyte detection
First Claim
1. A transdermal analyte monitoring system comprising:
- a sensor assembly, wherein the sensor assembly comprises a hydrogel and a sensor body containing a plurality of electrodes, wherein the sensor body is in fluid communication with the hydrogel, wherein the hydrogel comprises a humectant and an enzyme, and wherein the humectant is in an effective amount to increase the performance longevity of the transdermal analyte monitoring system, as indicated by decreased signal drift, compared to the same system in the absence of the humectant, andwherein the humectant is sodium pyrrolidone carboxylic acid (NaPCA).
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Abstract
Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective, semi-permeable membrane covering the surface of the hydrogel. The protective, semi-permeable membrane contacts with the skin of a user and prevents contamination or fouling of the hydrogel. Optionally, the hydrogel comprises one or more humectants and/or an immobilized enzyme. In another preferred embodiment, the TAMS contains at least one channel or pocket for increasing the amount of oxygen provided to the hydrogel. In one embodiment, a method for improving analyte detection by the TAMS is provided. For example, after the skin porosity is increased by an appropriate pretreatment, a skin preparation wipe is applied to the treated skin area and then the TAMS is applied to the treated area.
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Citations
16 Claims
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1. A transdermal analyte monitoring system comprising:
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a sensor assembly, wherein the sensor assembly comprises a hydrogel and a sensor body containing a plurality of electrodes, wherein the sensor body is in fluid communication with the hydrogel, wherein the hydrogel comprises a humectant and an enzyme, and wherein the humectant is in an effective amount to increase the performance longevity of the transdermal analyte monitoring system, as indicated by decreased signal drift, compared to the same system in the absence of the humectant, and wherein the humectant is sodium pyrrolidone carboxylic acid (NaPCA). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for increasing analyte detection by a transdermal analyte monitoring system comprising:
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(a) treating a region of skin of the user to increase permeability; and (b) applying to the treated region of skin a transdermal analyte monitoring system comprising a sensor assembly, wherein the sensor assembly comprises a hydrogel and a sensor body containing a plurality of electrodes, wherein the sensor body is in fluid communication with the hydrogel wherein the hydrogel comprises a humectant and an enzyme, and wherein the humectant is in an effective amount to increase the performance longevity of the transdermal analyte monitoring system, as indicated by decreased signal drift, compared to the same system in the absence of the humectant, and wherein the humectant is sodium pyrrolidone carboxylic acid (NaPCA). - View Dependent Claims (11, 12, 13, 14, 15, 16)
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Specification