Systems and methods for replacing signal artifacts in a glucose sensor data stream
First Claim
1. A method for processing data from a glucose sensor, the method comprising:
- applying a voltage to a working electrode of an electrochemical glucose sensor configured for invasive and/or minimally invasive subcutaneous implantation, invasive and/or minimally invasive transdermal implantation, or invasive and/or minimally invasive intravascular implantation;
performing at least one process selected from the group consisting of periodically switching the voltage applied to the working electrode of the glucose sensor, cycling the voltage applied to the working electrode of the glucose sensor, and pulsing the voltage applied to the working electrode of the glucose sensor, wherein the glucose sensor is configured to measure a glucose concentration in a host;
measuring a signal response of the working electrode to the at least one process; and
detecting a signal artifact based on the signal response.
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Abstract
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
599 Citations
19 Claims
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1. A method for processing data from a glucose sensor, the method comprising:
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applying a voltage to a working electrode of an electrochemical glucose sensor configured for invasive and/or minimally invasive subcutaneous implantation, invasive and/or minimally invasive transdermal implantation, or invasive and/or minimally invasive intravascular implantation; performing at least one process selected from the group consisting of periodically switching the voltage applied to the working electrode of the glucose sensor, cycling the voltage applied to the working electrode of the glucose sensor, and pulsing the voltage applied to the working electrode of the glucose sensor, wherein the glucose sensor is configured to measure a glucose concentration in a host; measuring a signal response of the working electrode to the at least one process; and detecting a signal artifact based on the signal response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system for processing data from a glucose sensor, the system comprising:
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an electrochemical glucose sensor comprising a working electrode, wherein the glucose sensor is configured for invasive and/or minimally invasive subcutaneous implantation, invasive and/or minimally invasive transdermal implantation, or invasive and/or minimally invasive intravascular implantation; and electronic circuitry configured to (i) apply a voltage to the working electrode (ii) switch, cycle, or pulse the voltage applied to the working electrode and to measure a signal response of the working electrode to the applied voltage, and (iii) detect a signal artifact based on the signal response. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A method for processing data from a glucose sensor, the method comprising:
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applying a voltage to a working electrode of an electrochemical glucose sensor configured for invasive and/or minimally invasive subcutaneous implantation, invasive and/or minimally invasive transdermal implantation, or invasive and/or minimally invasive intravascular implantation; performing at least one process selected from the group consisting of switching the voltage applied to the working electrode of a glucose sensor, cycling the voltage applied to the working electrode of a glucose sensor, and pulsing the voltage applied to the working electrode of a glucose sensor, wherein the glucose sensor is configured to measure a glucose concentration in a host; measuring a signal response of the working electrode to the process; measuring a temperature change using a temperature sensor; and detecting a signal artifact based on the signal response and the temperature change.
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19. A system for processing data from a glucose sensor, the system comprising:
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an electrochemical glucose sensor comprising a working electrode, wherein the glucose sensor is configured for invasive and/or minimally invasive subcutaneous implantation, invasive and/or minimally invasive transdermal implantation, or invasive and/or minimally invasive intravascular implantation; a temperature sensor configured to measure a temperature of a host; and electronic circuitry configured to (i) apply a voltage to the electrochemical glucose sensor, (ii) switch, cycle, or pulse the voltage applied to the working electrode and to (iii) measure a signal response of the working electrode to the applied voltage, wherein the electronic circuitry is configured to detect a signal artifact based on the signal response and the measured temperature.
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Specification