Apparatus for treating the physiological electric conduction of the heart

• US 8,812,106 B2
• Filed: 05/02/2013
• Issued: 08/19/2014
• Est. Priority Date: 12/20/2004
• Status: Active Grant

• Current Assignee: Newstim, Inc.
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Ortega, Daniel Felipe, Giniger, Alberto German
• Primary Examiner(s): DIETRICH, JOSEPH M
• Application Number:
  US13/875,681
• Publication Number:
  US 20130261690A1
• Time in Patent Office: 474 Days
• Field of Search: 607/9, 607/11, 607/15, 607/36, 607/122
• US Class Current: 607/9
• CPC Class Codes: A61N 1/362 Heart stimulators heart defibrillators A61N1/39
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation

Abstract

A new pacemaker apparatus for treating the physiological electric conduction of the heart that includes a conduction abnormality in a ventricle. The pacemaker includes a pulse generator and a pacing electrode located in the heart, the pulse generator providing pacing signals to the pacing electrode. The pacemaker further includes a signal generation circuit that generates electrical signals from heart-related feedback signals that indicate that the pacing electrode is delivering the pacing signals in a region at or near the His bundle of the heart. The combination of the pulse generator and the signal generation circuit indicates that the pacing electrode is delivering the pacing signals in the region, at or near the His bundle of the heart, to electrically bypass the conduction abnormality of the heart in the ventricle.

Claims

1. An apparatus, comprising:

an electrostimulation pulse generator, configured to provide an electrostimulation signal to a first electrode disposed in a subject heart; and

a His capture verification signal generator, configured to generate an electrical His capture verification signal based on information about whether the electrostimulation signal from the first electrode evokes a response that bypasses a ventricular conduction abnormality of the subject heart;

wherein the pulse generator provides the electrostimulation signal to the first electrode in the subject heart as an electrostimulation signal comprising at least partially concurrent opposite polarity signals.

2. The apparatus of claim 1, comprising the first electrode.

3. The apparatus of claim 2, comprising a second electrode, wherein the pulse generator is configured to provide a portion of the electrostimulation signal to the second electrode when the second electrode is disposed in the subject heart;

wherein the electrostimulation signal comprises a first monopolar pulse delivered from the first electrode with respect to a reference and a second monopolar pulse delivered from the second electrode with respect to the reference.

4. The apparatus of claim 3, wherein the pulse generator is configured to provide the electrostimulation using the first electrode being disposed in a first septal location in the right ventricle near a His bundle of the subject heart, and using the second electrode being disposed in a second septal location in the rig ventricle near the His bundle of the subject heart.

5. The apparatus of claim 1, comprising a catheter including the first electrode located on the catheter and the catheter having a deflectable sheath, wherein the deflectable sheath includes a distal electrode that is configured to be electrically coupled to the signal generator.

6. The apparatus of claim 1, comprising a control circuit, configured to determine whether a contraction of a ventricle of the subject heart responsive to the electrostimulation signal exhibits a desired depolarization-repolarization pattern.

7. The apparatus of claim 6, wherein the control circuit is configured to use the pulse generator to provide an electrostimulation signal to a second electrode disposed in the subject heart when the control circuit determines that the contraction responsive to the electrostimulation signal does not exhibit the desired depolarization-repolarization pattern.

8. The apparatus of claim 1, comprising a control circuit, configured to determine whether a contraction of a ventricle of the subject heart responsive to the electrostimulation signal exhibits a narrow QRS width.

9. The apparatus of claim 8, wherein the control circuit is configured to use the pulse generator to provide an electrostimulation signal to a second electrode disposed in the subject heart when the control circuit determines that the contraction responsive to the electrostimulation signal does not exhibit the narrow QRS width.

10. An apparatus for treating a ventricular conduction abnormality of a subject heart, comprising:

first and second electrodes configured to he disposed in the subject heart, at least one of the first and second electrodes being configured to be secured to a septal location of the subject heart;

a pulse generator, configured to provide an electrostimulation signal to the first and second electrodes; and

a His capture verification signal generator, configured to generate an electrical His capture verification signal based on information about whether the electrostimulation signal from the first and second electrodes evokes a response that bypasses the ventricular conduction abnormality of the subject heart;

wherein the pulse generator is configured to provide the electrostimulation signal to the first and second electrodes as respective electrostimulation signal pulses having at least partially concurrent opposite polarity.

11. The apparatus of claim 10, comprising the first and second electrodes configured to be disposed in a septal region of the subject heart.

12. The apparatus of claim 11, wherein the pulse generator is configured to provide the electrostimulation signal comprising electrostimulation pulses comprising a first monopolar pulse to be provided to the first electrode with respect to an electrical reference and a second monopolar pulse to be provided to the second electrode with respect to the electrical reference.

13. The apparatus of claim 10, wherein the His capture verification signal generator is configured to generate the electrical His capture verification signal to indicate a delay between a beginning of a QRS complex and an activation of the left ventricle free wall at a point distal from the apex of the left ventricle.

14. The apparatus of claim 10, comprising a removable guide sheath that comprises the first and second electrodes.

15. The apparatus of claim 14, wherein the removable guide sheath is deflectable to guide the first and second electrodes to a target pacing region in the subject heart at or near the septal wall.

16. The apparatus of claim 10, wherein the His capture verification signal generator is configured to generate the electrical His capture verification signal based on information about whether the electrostimulation signal from the first and second electrodes evokes a response that bypasses a bundle branch block.

17. An apparatus, comprising:

first and second electrodes disposed in a subject ventricle at or near the septal wall of a subject heart;

a pulse generator, configured to provide an electrostimulation signal to the first and second electrodes;

a His capture verification signal generator, configured to generate an electrical His capture verification signal based on information, received using a third electrode, about whether the electrostimulation signal evokes a response indicating a conduction abnormality of the subject heart is bypassed;

wherein the pulse generator provides the electrostimulation signal to the first and second electrodes as respective electrostimulation signal pulses that are at least partially concurrent and of opposite polarity.

18. The apparatus of claim 17, wherein the pulse generator provides the electrostimulation signal pulses as a first monopolar pulse delivered from the first electrode with respect to a reference and a second monopolar pulse delivered from the second electrode with respect to the reference.

19. The apparatus of claim 17, wherein the His capture verification signal generator is configured to include, in the electrical His capture verification signal, information about whether a subject bundle branch block is bypassed.

20. The apparatus of claim 17, comprising the third electrode, wherein the third electrode is disposed on a sheath that is removable from a catheter, and the catheter includes the first and second electrodes.