Fibrin pad matrix with suspended heat activated beads of adhesive

• US 8,814,025 B2
• Filed: 09/15/2011
• Issued: 08/26/2014
• Est. Priority Date: 09/15/2011
• Status: Active Grant

• Current Assignee: Ethicon Endo-Surgery, Inc. (Johnson & Johnson)
• Original Assignee: Ethicon Endo-Surgery, Inc. (Johnson & Johnson)
• Inventors: Miller, Matthew C., Nur, Israel, Zingman, Aron O., Wang, Yi-Lan
• Primary Examiner(s): Smith, Scott A.
• Application Number:
  US13/233,633
• Publication Number:
  US 20130068820A1
• Time in Patent Office: 1,076 Days
• Field of Search: 227/19, 227/175.1, 227/176.1, 227/179.1, 227/180.1, 606/139, 606/213, 606/219, 606/229, 606/151, 606/153
• US Class Current: 227/180.1
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/07207 the staples being applied sequentially
• CPC Class Codes: A61B 17/07292 Reinforcements for staple line, e.g. pledgets
• CPC Class Codes: A61B 2017/005 hardenable using external energy source, e.g. laser, ultrasound
• CPC Class Codes: A61B 2017/2929 with a head rotatable about the longitudinal axis of the shaft

Abstract

A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a cartridge when in an open position. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further receives a matrix including glue beads suspended in the matrix. The staples are driven through the matrix to secure the matrix to tissue. The glue beads are activated when the matrix is secured to the tissue, such that the activated adhesive further secures the staple line in the tissue.

Claims

1. A surgical instrument comprising:

(a) a handle portion;

(b) a shaft housing a firing bar;

(c) an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft; and

(d) a cartridge, wherein the lower jaw is configured to receive the cartridge when the end effector is in an open position, wherein the cartridge comprises;

(i) a housing,

(ii) a plurality of staples disposed in the housing,

(iii) a deck disposed over the plurality of staples, the deck defining apertures, each aperture being substantially disposed over each staple, and

(iv) a matrix including glue beads suspended in the matrix.

2. The cartridge of claim 1, wherein each glue bead of the glue beads suspended in the matrix comprises glue and a housing, wherein the housing of each glue bead comprises a solid material, wherein the glue is disposed in the solid housing.

3. The cartridge of claim 1, wherein the glue beads suspended are freeze dried.

4. The cartridge of claim 1, wherein the glue beads comprise an adhesive that is selected from the group consisting of the following:

polymerizable monomer, a polymerizable 1,1-disubstituted ethylene monomer, and a cyanoacrylate formulation.

5. The cartridge of claim 1, wherein the matrix comprises a biocompatible material.

6. The cartridge of claim 1, wherein the matrix comprises one of fibrin or thrombin.

7. The cartridge of claim 1, wherein each glue bead is substantially disposed over each aperture of the deck.

8. The cartridge of claim 1, wherein the matrix comprises a cartridge portion, an anvil portion, and an intermediate portion disposed therebetween, the anvil portion including a flap which is configured for receipt of a distal end of the anvil.

9. The cartridge of claim 8, wherein the deck of the cartridge includes one or more hooks, wherein the hooks are configured to secure the matrix to the deck of the cartridge.

10. The cartridge of claim 8, wherein the intermediate portion comprises a preformed bend.

11. The cartridge of claim 1, wherein the matrix comprises at least one of a hemostatic agent, a sealant, or an adhesive.

12. The cartridge of claim 1, wherein the staples comprise a material selected from at least one of the following materials:

iron, nickel titanium alloy, stainless steel, and titanium.

13. The cartridge of claim 1, wherein the matrix comprises a biocompatible material selected from a group consisting of at least one of the following materials:

epsilon-caprolactone glycolide, bovine pericardium, polylactic acid, polyglycolic acid, polyglactin, polydioxanone, polyglyconate, whey protein, cellulose gum, starch, gelatin, silk, nylon, polypropylene, braided polyester, polybutester, polyethylene, and polyetheretherketones.

14. The cartridge of claim 1, wherein the matrix comprises a biocompatible material selected from a group consisting of at least one of the following:

a buttress, a matrix having a plurality of openings therein, an open cell foam, a closed cell foam, and a fabric pad.

15. The cartridge of claim 1, wherein the matrix includes at least one wicking feature.

16. A method of releasing and activating adhesive with a surgical instrument, the surgical instrument including an end effector, a handle portion, a shaft, a stapling and severing assembly, a matrix, and a removable cartridge, wherein the end effector comprises a lower jaw and an anvil, the lower jaw being configured to receive a removable cartridge, wherein the stapling and severing assembly is responsive to a longitudinal closing motion produced by the handle portion and the shaft, wherein the matrix includes glue beads suspended in the matrix, wherein the cartridge includes an exterior top surface, wherein a first portion of the matrix is disposed on the exterior top surface of the cartridge, the method comprising the steps of:

(a) disposing the matrix on the end effector of the surgical instrument between the lower jaw and the anvil;

(b) activating the stapling and severing assembly to drive staples through the matrix; and

(c) applying at least one of heat or moisture to the matrix to an amount sufficient to activate the glue beads suspended in the matrix.

17. The method of claim 16, wherein the step of disposing the matrix on the end effector comprises:

(i) inserting the removable cartridge into the lower jaw, and

(ii) disposing a second portion of the matrix on an underside of the anvil.

18. The method of claim 16, wherein the step of disposing the matrix on the end effector comprises:

(i) disposing a first portion of the matrix on the exterior top surface of the cartridge, and

(ii) attaching the first portion of the matrix to the exterior top surface via a series of hooks extending from the exterior top surface.

19. The method of claim 16, wherein the step of disposing the matrix on the end effector comprises:

(i) disposing a second portion of the matrix on an underside of the anvil, and

(ii) inserting a distal end of the anvil into a flap on the second portion of the matrix, wherein the flap is configured for receipt of the distal end of the anvil.

20. A surgical instrument comprising:

(a) a handle portion;

(b) a shaft, the shaft housing a firing bar;

(c) a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft;

(d) a staple cartridge, wherein the staple cartridge comprises;

(i) a plurality of staples, and

(ii) a deck disposed over the plurality of staples, the deck defining apertures, each aperture being substantially disposed over at least one respective staple;

(e) an end effector connected to the shaft, the end effector comprising an anvil and a lower jaw, the cartridge being received in the lower jaw, the anvil being configured to form the staples in response to a longitudinal closing motion when the end effector is in a closed position; and

(f) a biocompatible material containing glue beads suspended in a matrix, the biocompatible material being releasably attached to the cartridge and the anvil;

wherein the staples are operable to be driven through the biocompatible material.