Instrumentation and method for optical measurement of samples
First Claim
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1. An optical measurement instrument comprising:
- at least one excitation light source (101, 102) each of which being arranged to produce an excitation beam for at least one of samples (103-109, 203-210) to be measured, each sample to be measured being stored in one of a plurality of sample wells (111-117),at least one detector (119, 120) each of which being arranged to detect an emission beam emitted by one of the samples to be measured and to produce a detection signal responsive to the detected emission beam,a processing device (121) for producing a measurement result for each sample to be measured on the basis of the detection signal related to that sample, andat least one temperature sensor (122) arranged to measure sample well specific temperatures from the sample wells, the at least one temperature sensor being capable of measuring different temperatures from different sample wells, and the processing device is arranged to correct the measurement result related to each sample to be measured on the basis of the sample well specific temperature measured from the particular sample well containing that sample,wherein the plurality of the sample wells (111-117) are movable with respect to the at least one temperature sensor (122) so as to enable each temperature sensor to measure the sample well specific temperatures from more than one sample well, and the at least one temperature sensor is arranged to measure the sample well specific temperature from a particular one of the sample wells (112) that is in such a mechanical position that the detector (119, 120) is able to detect the emission beam emitted by the sample stored in that particular sample well.
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Abstract
An optical measurement instrument includes one or more temperature sensors (122) arranged to measure sample well specific temperatures from sample wells (111-117) arranged to store samples (103-109) to be optically measured. A processing device (121) of the optical measurement instrument is arranged to correct, using a pre-determined mathematical rule, measurement results obtained by the optical measurements on the basis of the measured sample well specific temperatures. Hence, the adverse effect caused by temperature differences between different samples on the accuracy of the temperature correction of the measurement results is mitigated.
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Citations
10 Claims
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1. An optical measurement instrument comprising:
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at least one excitation light source (101, 102) each of which being arranged to produce an excitation beam for at least one of samples (103-109, 203-210) to be measured, each sample to be measured being stored in one of a plurality of sample wells (111-117), at least one detector (119, 120) each of which being arranged to detect an emission beam emitted by one of the samples to be measured and to produce a detection signal responsive to the detected emission beam, a processing device (121) for producing a measurement result for each sample to be measured on the basis of the detection signal related to that sample, and at least one temperature sensor (122) arranged to measure sample well specific temperatures from the sample wells, the at least one temperature sensor being capable of measuring different temperatures from different sample wells, and the processing device is arranged to correct the measurement result related to each sample to be measured on the basis of the sample well specific temperature measured from the particular sample well containing that sample, wherein the plurality of the sample wells (111-117) are movable with respect to the at least one temperature sensor (122) so as to enable each temperature sensor to measure the sample well specific temperatures from more than one sample well, and the at least one temperature sensor is arranged to measure the sample well specific temperature from a particular one of the sample wells (112) that is in such a mechanical position that the detector (119, 120) is able to detect the emission beam emitted by the sample stored in that particular sample well. - View Dependent Claims (2, 3, 4, 5, 6)
wherein Mcorr is the corrected measurement result, M is the measurement result, and F(T) is a pre-determined function of the sample well specific temperature T measured from the particular sample well containing the sample under consideration.
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6. The optical measurement instrument according to claim 1, wherein the processing device is arranged to correct the measurement result related to each sample to be measured according to the following rule:
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Mcorr=M×
α
(T0-T),wherein Mcorr is the corrected measurement result, M is the measurement result, α and
T0 are predetermined constants, and T is the sample well specific temperature measured from the particular sample well containing the sample under consideration.
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7. A method for making temperature corrections to measurement results taken with an optical measurement instrument that comprises:
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at least one excitation light source each of which being arranged to produce an excitation beam for at least one of samples to be measured, each sample to be measured being stored in one of a plurality of sample wells, at least one detector each of which being arranged to detect an emission beam emitted by one of the samples to be measured and to produce a detection signal responsive to the detected emission beam, and a processing device for producing the measurement result for each sample to be measured on the basis of the detection signal related to that sample, the method comprising; measuring (401), with a temperature sensor, sample well specific temperatures from the sample wells, and correcting (402) the measurement result related to each sample to be measured on the basis of the sample well specific temperature measured from the particular sample well containing that sample, wherein the method further comprises; moving the plurality of the sample wells with respect to the temperature sensor so as to enable the temperature sensor to measure the sample well specific temperatures from more than one sample well, and measuring the sample well specific temperature from each particular sample well when that particular sample well is in such a mechanical position that the detector is able to detect the emission beam emitted by the sample stored in that particular sample well. - View Dependent Claims (8, 9, 10)
wherein Mcorr is the corrected measurement result, M is the measurement result, and F(T) is a pre-determined function of the sample well specific temperature T measured from the particular sample well containing the sample under consideration.
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10. The method according to claim 7, wherein the measurement result related to each sample to be measured is corrected according to the following rule:
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Mcorr=M×
α
(T0-T),wherein Mcorr is the corrected measurement result, M is the measurement result, α and
T0 are predetermined constants, and T is the sample well specific temperature measured from the particular sample well containing the sample under consideration.
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Specification