Irreversible electroporation using nanoparticles
First Claim
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1. A method of treating a subject having a neoplasia, the method comprising:
- identifying a treatment area in the subject, wherein the treatment area comprises the neoplasia;
providing nanoparticles modified to selectively bind to neoplastic cells of the neoplasia;
administering the nanoparticles to the treatment area in an amount sufficient to permit at least some of the nanoparticles to bind to the neoplastic cells;
positioning at least one electrode into or adjacent to the neoplastic cells; and
applying an electric field to the treatment area by delivering electrical pulses from the at least one electrode to irreversibly electroporate the neoplastic cells.
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Abstract
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.
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16 Claims
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1. A method of treating a subject having a neoplasia, the method comprising:
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identifying a treatment area in the subject, wherein the treatment area comprises the neoplasia; providing nanoparticles modified to selectively bind to neoplastic cells of the neoplasia; administering the nanoparticles to the treatment area in an amount sufficient to permit at least some of the nanoparticles to bind to the neoplastic cells; positioning at least one electrode into or adjacent to the neoplastic cells; and applying an electric field to the treatment area by delivering electrical pulses from the at least one electrode to irreversibly electroporate the neoplastic cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of treating a subject having a neoplasia, the method comprising:
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identifying in the subject a treatment area containing the neoplasia; administering to the treatment area a plurality of nanoparticles that have been functionalized to selectively target neoplastic cells of the neoplasia such that at least some of the nanoparticles bind to the neoplastic cells; positioning at least one electrode into or adjacent) the neoplastic cells; and applying through the at least one electrode a plurality of electrical pulses to the treatment area that have been administered with the functionalized nanoparticles to kill the neoplastic cells. - View Dependent Claims (14, 15, 16)
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Specification