Drug eluting medical devices having porous layers
First Claim
1. A method of forming an implantable or insertable medical device comprising:
- (a) forming a predecessor structure that comprises an assembly of microspheres disposed over an underlying substrate, the microspheres carrying a first therapeutic agent, the first therapeutic agent being loaded to the microspheres by conjugating the first therapeutic agent with a surface of the microspheres or by forming a coating layer containing the first therapeutic agent on the microspheres,(b) mixing with or conjugating to a biodegradable polymer a second therapeutic agent and using the mixed or conjugated biodegradable polymer and the second therapeutic agent to form a biodegradable, porous layer over said substrate using said microspheres as templates for pores of the porous layer,(c) removing portions of or all of the microspheres to form the porous layer, with the pores containing the first therapeutic agent, and(d) loading the pores of the porous layer with a third therapeutic agent.
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Accused Products
Abstract
In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.
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Citations
19 Claims
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1. A method of forming an implantable or insertable medical device comprising:
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(a) forming a predecessor structure that comprises an assembly of microspheres disposed over an underlying substrate, the microspheres carrying a first therapeutic agent, the first therapeutic agent being loaded to the microspheres by conjugating the first therapeutic agent with a surface of the microspheres or by forming a coating layer containing the first therapeutic agent on the microspheres, (b) mixing with or conjugating to a biodegradable polymer a second therapeutic agent and using the mixed or conjugated biodegradable polymer and the second therapeutic agent to form a biodegradable, porous layer over said substrate using said microspheres as templates for pores of the porous layer, (c) removing portions of or all of the microspheres to form the porous layer, with the pores containing the first therapeutic agent, and (d) loading the pores of the porous layer with a third therapeutic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification