Temperature telemetry in processing of material

• US 8,815,326 B2
• Filed: 07/23/2008
• Issued: 08/26/2014
• Est. Priority Date: 07/27/2007
• Status: Expired due to Fees

• Current Assignee: GlaxoSmithKline LLC (GSK plc)
• Original Assignee: GlaxoSmithKline LLC (GSK plc)
• Inventors: Arp, Zane A., McDade, Christine
• Primary Examiner(s): SELLMAN, CACHET I
• Application Number:
  US12/670,084
• Publication Number:
  US 20100203227A1
• Time in Patent Office: 2,225 Days
• Field of Search: 427/2.1, 427/2.14, 427/2.15, 427/2.18, 427/8, 427/212, 340/870.17, 340/870.01, 340/870.11, 424/464, 424/474, 424/489, 424/490
• US Class Current: 427/2.14
• CPC Class Codes: G01K 1/024 for remote indication
• CPC Class Codes: G01K 13/00 Thermometers specially adapted for specific purposes
• CPC Class Codes: G01K 13/04 for measuring temperature of moving solid bodies
• CPC Class Codes: G01K 2007/422 Dummy objects used for estimating temperature of real objects

Abstract

In the process of coating pharmaceutical tablets in a moving bed, the temperature of the tablets is measured by incorporating a temperature transducer in the form of tablet into the bed of tablets, and transmitting temperature data to an external receiver by wireless telemetry.

Claims

1. A method of monitoring the temperature of a mass of pharmaceutical dosage forms being subjected to a processing step in which said mass of pharmaceutical dosage forms is caused to flow, the method comprising:

including within said mass of pharmaceutical dosage forms a temperature monitoring transducer said transducer being freely movable relative to each of the pharmaceutical dosage forms within said mass; and

while said mass of pharmaceutical dosage forms is flowing, transmitting temperature data from said monitoring transducer by wireless telemetry to a receiver external to said mass of pharmaceutical dosage forms;

wherein the temperature monitoring transducer moves within said mass of pharmaceutical dosage forms during said processing step;

wherein the size, shape and weight of the temperature monitoring transducer are such that its movement within said mass of pharmaceutical dosage forms is substantially indistinguishable from the movement of said dosage forms; and

wherein said temperature monitoring transducer is a non-pharmaceutical device consisting essentially of an external shell, and, within said external shell, a temperature sensor, a wireless transmitter, and electronic circuitry causing the wireless transmitter to transmit data corresponding to the temperature as sensed by the temperature sensor.

2. The method according to claim 1, in which the processing step is a coating step.

3. The method according to claim 1, in which the processing step is a coating step in which a coating material is sprayed onto the pharmaceutical dosage forms while the pharmaceutical dosage forms are being tumbled.

4. The method according to claim 1, in which plural temperature monitoring transducers are embedded within said mass of pharmaceutical dosage forms, said temperature monitoring transducers being freely movable relative to one another and to each of the pharmaceutical dosage forms within said mass, and temperature data are transmitted from said temperature monitoring transducers, by wireless telemetry, to a receiver external to said mass of pharmaceutical dosage forms, and in which each of said temperature monitoring transducers is a non-pharmaceutical device consisting essentially of an external shell, and, within said external shell, a temperature sensor, a wireless transmitter, and electronic circuitry causing the wireless transmitter to transmit data corresponding to the temperature as sensed by the temperature sensor.

5. The method according to claim 1, in which plural temperature monitoring transducers are embedded within said mass of pharmaceutical dosage forms, said temperature monitoring transducers being freely movable relative to one another and to each of the pharmaceutical dosage forms within said mass, and temperature data are transmitted from said temperature monitoring transducers over independent wireless channels to a receiver external to said mass of pharmaceutical dosage forms, whereby the temperature of each transducer can be ascertained independently, and in which each of said temperature monitoring transducers is a non-pharmaceutical device consisting essentially of an external shell, and, within said external shell, a temperature sensor, a wireless transmitter, and electronic circuitry causing the wireless transmitter to transmit data corresponding to the temperature as sensed by the temperature sensor.

6. A method of monitoring the temperature of pharmaceutical dosage forms in a bed comprising multiple dosage forms in a random array being subjected to a processing step in which said dosage forms are being tumbled, the method comprising:

including a temperature monitoring transducer within said bed, said transducer being freely movable relative to each of the pharmaceutical dosage forms within said bed; and

transmitting temperature data from said monitoring transducer by wireless telemetry to a receiver external to said bed;

wherein the temperature monitoring transducer moves within said dosage forms as the dosage forms are being tumbled;

wherein the size, shape and weight of the temperature monitoring transducer are such that its movement within said dosage forms is substantially indistinguishable from the movement said dosage forms while said dosage forms are being tumbled; and

wherein said temperature monitoring transducer is a non-pharmaceutical device consisting essentially of an external shell, and, within said external shell, a temperature sensor, a wireless transmitter, and electronic circuitry causing the wireless transmitter to transmit data corresponding to the temperature as sensed by the temperature sensor.

7. The method of claim 6, in which the processing step is a coating step.

8. The method according to claim 6, in which the processing step is a coating step in which a coating material is sprayed onto the pharmaceutical dosage forms and the transducer while the pharmaceutical dosage forms are being tumbled.

9. The method according to claim 6, in which plural temperature monitoring transducers are included within said bed, said temperature monitoring transducers being freely movable relative to one another and to each of the pharmaceutical dosage forms within said bed, and temperature data are transmitted from said temperature monitoring transducers, by wireless telemetry, to a receiver external to said bed, and in which each of said temperature monitoring transducers is a non-pharmaceutical device consisting essentially of an external shell, and, within said external shell, a temperature sensor, a wireless transmitter, and electronic circuitry causing the wireless transmitter to transmit data corresponding to the temperature as sensed by the temperature sensor.

10. The method according to claim 6, in which plural temperature monitoring transducers are included within said bed, said temperature monitoring transducers being freely movable relative to one another and to each of the pharmaceutical dosage forms within said bed, and temperature data are transmitted over independent wireless channels from said temperature monitoring transducers to a receiver external to said bed, whereby the temperature of each transducer can be ascertained independently, and in which each of said temperature monitoring transducers is a non-pharmaceutical device consisting essentially of an external shell, and, within said external shell, a temperature sensor, a wireless transmitter, and electronic circuitry causing the wireless transmitter to transmit data corresponding to the temperature as sensed by the temperature sensor.