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Multiplanar lateral flow assay with diverting zone

  • US 8,815,609 B2
  • Filed: 03/07/2013
  • Issued: 08/26/2014
  • Est. Priority Date: 05/20/2008
  • Status: Active Grant
First Claim
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1. A lateral flow device for detecting an analyte in a sample comprising:

  • a sample compressor;

    a test strip comprising a test zone and a diverting zone upstream of the test zone, wherein the diverting zone interrupts lateral flow on the test strip;

    a conjugate comprising a first binding partner for the analyte and a label; and

    a second binding partner for the analyte; and

    a sample application zone where sample is applied to the lateral flow device, wherein the sample application zone is located in a location selected from the group consisting of;

    i) on the test strip upstream of the detection zone;

    ii) on the sample compressor; and

    iii) on a sample collector comprising a sample collection portion for collection of the sample;

    wherein a component selected from the group consisting of the conjugate, the second binding partner and both the conjugate and the second binding partner is not located on the test strip prior to use of the lateral flow device; and

    wherein the sample compressor creates a bridge over the diverting zone to divert flow onto the sample compressor and return flow to the test strip at the end of the diverting zone.

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