Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors
First Claim
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1. A method of inhibiting angiogenesis in a subject, comprising:
- administering to the subject a polynucleotide of at least 15 bases that specifically hybridizes under physiological conditions to a nucleic acid having the nucleotide sequence of SEQ ID NO;
1,thereby inhibiting angiogenesis in the subject.
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Abstract
Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.
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Citations
19 Claims
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1. A method of inhibiting angiogenesis in a subject, comprising:
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administering to the subject a polynucleotide of at least 15 bases that specifically hybridizes under physiological conditions to a nucleic acid having the nucleotide sequence of SEQ ID NO;
1,thereby inhibiting angiogenesis in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of inhibiting angiogenesis in a subject, comprising:
administering to the subject an antisense polynucleotide of at least 15 bases capable of hybridizing under physiological conditions to an mRNA encoding a polypeptide comprising the amino acid sequence set forth in SEQ ID NO;
2, thereby inhibiting angiogenesis in the subject.- View Dependent Claims (12, 13, 14)
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15. A method of inhibiting angiogenesis in a subject, comprising:
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administering to the subject a polynucleotide of at least 15 bases that is complementary to a nucleic acid having the nucleotide sequence of SEQ ID NO;
1,thereby inhibiting angiogenesis in the subject. - View Dependent Claims (16, 17, 18, 19)
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Specification