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Aerosol fluoroquinolone formulations for improved pharmacokinetics

  • US 8,815,838 B2
  • Filed: 10/06/2009
  • Issued: 08/26/2014
  • Est. Priority Date: 10/07/2008
  • Status: Active Grant
First Claim
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1. A method for treating a pulmonary infection, comprising administering to a human having said pulmonary infection an aerosol of a solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation to achieve a maximum lung sputum concentration (Cmax) of at least 1200 mg/L and a lung sputum area under the curve (AUC) of at least 1500 h·

  • mg/L, wherein the solution comprises a divalent or trivalent cation concentration from about 50 mM to about 400 mM, and a levofloxacin or ofloxacin concentration from between about 50 mg/ml to about 200 mg/ml.

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