Pyrazole aminopyrimidine derivatives as LRRK2 modulators

• US 8,815,882 B2
• Filed: 11/09/2011
• Issued: 08/26/2014
• Est. Priority Date: 11/10/2010
• Status: Active Grant

• Current Assignee: F Hoffmann-La Roche AG (Roche Holding AG)
• Original Assignee: Genentech, Inc. (Roche Holding AG)
• Inventors: Baker-Glenn, Charles, Burdick, Daniel Jon, Chambers, Mark, Chan, Bryan K., Chen, Huifen, Estrada, Anthony, Sweeney, Zachary Kevin
• Primary Examiner(s): Rao, Deepak
• Assistant Examiner(s): Pagano, Alexander R
• Application Number:
  US13/292,668
• Publication Number:
  US 20120157427A1
• Time in Patent Office: 1,021 Days
• Field of Search: 544/320, 544/321, 544/324, 544/331, 514/272, 514/275
• US Class Current: 514/272
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 403/14 containing three or more hetero rings
• CPC Class Codes: C07D 405/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/14 containing three or more hetero rings

Abstract

Compounds of the formula I:

• or pharmaceutically acceptable salts thereof,
• wherein X, R¹, R², R³, R⁴ and R⁵ are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson'"'"'s disease.

Claims

1. A compound of the formula I:

2. The compound of claim 1, wherein X is —

NH—

or —

O—

.

3. The compound of claim 1, wherein R¹ is:

C_1-6alkyl;

halo-C_1-6alkyl;

C_1-6alkoxy-C_1-6alkyl;

amino-C_1-6alkyl;

C_1-6alkylsulfonyl-C_1-6alkyl;

C_3-6cycloalkyl;

or C_3-6cycloalkyl-C_1-6alkyl.

4. The compound of claim 1, wherein R¹ is C_1-6alkyl.

5. The compound of claim 1, wherein R² is:

fluoro;

bromo;

chloro;

iodo;

trifluoromethyl;

or cyano.

6. The compound of claim 1, wherein R³ is:

methyl;

ethyl;

propyl;

isopropyl;

butyl;

cyclopropyl;

cyclopropylmethyl;

cyclobutyl;

methanesulfonyl;

ethylsulfonyl;

cyclopropylsulfonyl;

sec-butylsulfonyl;

morpholin-4-yl-ethyl;

oxetan-3-yl;

2-methoxyethyl;

2-hydroxy-2-methyl-propyl;

3-hydroxy-2-methyl-propan-2-yl;

2-methoxy-propyl;

tetrahydro-2H-pyran-4-yl;

tetrahydrofuran-3-yl;

2,6-dimethyltetrahydro-2H-pyran-4-yl;

tetrahydro-2H-pyran-3-yl);

phenyl;

4-(methylsulfonyl)phenyl);

4-cyano-phenyl;

4-fluoro-phenyl;

4-chloro-phenyl;

3,5-difluorophenyl;

4-(dimethylamino-carbonyl)-phenyl);

4-(cyclopropylsulfonyl)phenyl;

2,2,2-trifluoroethyl;

2-fluoroethyl;

difluoromethyl;

2-dimethyl-1,3-dioxan-5-yl;

1-methyl-cyclopropyl-carbonyl;

3-methylpyridin-4-yl;

2-methylpyridin-4-yl;

pyridin-2-yl;

pyrimidin-2-yl;

pyrimidin-5-yl;

pyridin-2-ylmethyl;

1-(pyridin-2-yl)ethyl;

cyclopropylsulfonyl;

1-cyano-1-methyl-ethyl;

2-cyano-ethyl;

1-cyano-ethyl;

2-cyano-2-methyl-propyl;

1-(2,2,2-trifluoroethyl)piperidin-4-yl;

1-(methylsulfonyl)azetidin-3-yl;

(3-methyloxetan-3-yl)methyl;

(1S,5S)-8-oxabicyclo[3.2.1]octan-3-yl;

1-(oxetan-3-yl)piperidin-4-yl;

1-acetyl-piperidin-4-yl;

1-(cyclopropyl-carbonyl)-piperidin-4-yl;

1-methyl-piperidin-4-yl;

1-methyl-2-oxo-piperidin-5-yl;

2-oxo-piperidin-5-yl;

1-(isopropyl-carbonyl)-piperidin-4-yl;

1-(oxetan-3-yl)azetidin-3-yl;

1-(cyclopropyl-carbonyl)-piperidin-4-yl;

2-methoxycyclopentyl;

3-methoxycyclopentyl;

1-methoxy-2-methylpropan-2-yl;

tetrahydro-2H-1,1-dioxo-thiopyran-4-yl;

3-fluoro-1-(oxetan-3-yl)piperidin-4-yl;

1-methoxypropan-2-yl;

1-(2,2,2-trifluoroethyl)azetidin-3-yl);

1-(oxetan-3-yl)pyrrolidin-3-yl;

1-isopropylazetidin-3-yl;

3-fluoro-1-methylpiperidin-4-yl;

1-ethyl-3-fluoropiperidin-4-yl;

1-methylpyrrolidin-3-yl;

2-methoxyethyl)piperidin-4-yl);

1-methyl-1-(methylamino-carbonyl)-ethyl;

2-methyl-2-morpholino-propyl;

4,4-difluorocyclohexyl;

morpholin-4-yl-carbonyl;

dimethylamino-carbonyl-methyl;

methylamino-carbonyl-methyl;

1-methyl-1-(dimethylamino-carbonyl)-ethyl;

pyrrolidin-′

-yl-carbonyl;

1-cyamo-cyclopropyl;

1-(pyrrolidin-′

-yl-carbonyl)-ethyl;

1-(dimethylamino-carbonyl)-ethyl;

1-(methoxy-carbonyl)-ethyl;

1-(tert-butylamino-carbonyl)-1-methyl-ethyl;

1-(2,2,2-trifluoroethyllamino-carbonyl)-1-methyl-ethyl;

1-(ethylamino-carbonyl)-1-methyl-ethyl;

1-(cyclopropylmethylamino-carbonyl)-1-methyl-ethyl;

1-(ethylamino-carbonyl)-cyclobutyl;

1-(isopropylamino-carbonyl)-1-methyl-ethyl;

1-cyano-cyclobutyl;

2-methoxy-1-methyl-ethyl;

1-methyl-1-(methoxy-carbonyl)-ethyl;

2-methoxy-2-methyl-propan-1-yl;

1-(oxetan-3-yl)-pyrrolidin-3-yl;

isopropylsulfonyl;

butane-2-sulfonyl;

1-(2-fluoroethyl)-piperidin-4-yl;

3-fluoro-1-methyl-piperidin-4-yl;

1-ethyl-3-fluoro-piperidin-4-yl;

pyridin-3-ylmethyl;

6-methyl-pyridin-2-ylmethyl;

2-(morpholin-1-yl)-1,1,dimethyl-ethyl;

pyrimdin-2-yl-methyl;

3-fluoro-1-(oxetan-3-yl)-piperidin-4-yl;

1-(oxetan-3-yl)-piperidin-3-yl;

1-([1,3]Dioxolan-2-ylmethyl)-piperidin-4-yl;

pyridazin-3-ylmethyl;

piperidin-3-yl;

pyrazin-2-ylmethyl;

2-hydroxy-3-methyl-butan-1-yl;

1-([1,3]Dioxolan-2-ylmethyl)-pyrrolidin-3-yl;

pyrimidin-4-ylmethyl;

1-methyl-1H-pyrazol-3-ylmethyl;

1-methyl-1-(4H-[1,2,4]triazol-3-yl)-ethyl;

1-methyl-1-(5-methyl-4H-[1,2,4]triazol-3-yl)-ethyl;

3-fluoro-piperidin-4-yl;

2-hydroxy-cyclopentyl;

dimethyl-[1,3]dioxan-5-yl;

2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-yl;

2-(4-methyl-4H-1,2,4-triazol-3-yl)propan-2-yl;

2-(1-methyl-1H-1,2,4-triazol-3-yl)propan-2-yl;

2-(1-methyl-1H-pyrazol-4-yl)propan-2-yl;

2-(1-methyl-1H-pyrazol-3-yl)propan-2-yl;

2-(1-methyl-1H-pyrazol-5-yl;

2-(4H-1,2,4-triazol-3-yl)propan-2-yl;

or 1-methyl-1H-pyrazole-4-yl.

7. The compound of claim 1, wherein R⁵ is C_1-6alkyl.

8. The compound of claim 1, wherein R⁵ is hydrogen or methyl.

9. The compound of claim 1, wherein said compounds are of formula II

10. The compound of claim 1, wherein said compound is of formula III

11. The compound of claim 1, wherein said compound is of formula IV

12. The compound of claim 1, wherein said compound is of formula V

13. A composition comprising:

(a) a pharmaceutically acceptable carrier; and

(b) a compound of claim 1.

14. The compound of claim 10, wherein R¹ is methyl, ethyl or isopropyl.

15. The compound of claim 14, wherein R² is chloro;

trifluoromethyl;

or cyano.

16. The compound of claim 15, wherein R³ is:

methyl;

ethyl;

propyl;

isopropyl;

butyl;

cyclopropyl;

cyclopropylmethyl;

cyclobutyl;

methanesulfonyl;

ethylsulfonyl;

cyclopropylsulfonyl;

sec-butylsulfonyl;

morpholin-4-yl-ethyl;

oxetan-3-yl;

2-methoxyethyl;

2-hydroxy-2-methyl-propyl;

3-hydroxy-2-methyl-propan-2-yl;

2-methoxy-propyl;

tetrahydro-2H-pyran-4-yl;

tetrahydrofuran-3-yl;

2,6-dimethyltetrahydro-2H-pyran-4-yl;

tetrahydro-2H-pyran-3-yl);

phenyl;

4-(methylsulfonyl)phenyl);

4-cyano-phenyl;

4-fluoro-phenyl;

4-chloro-phenyl;

3,5-difluorophenyl;

4-(dimethylamino-carbonyl)-phenyl);

4-(cyclopropylsulfonyl)phenyl;

2,2,2-trifluoroethyl;

2-fluoroethyl;

difluoromethyl;

2-dimethyl-1,3-dioxan-5-yl;

1-methyl-cyclopropyl-carbonyl;

3-methylpyridin-4-yl;

2-methylpyridin-4-yl;

pyridin-2-yl;

pyrimidin-2-yl;

pyrimidin-5-yl;

pyridin-2-ylmethyl;

1-(pyridin-2-yl)ethyl;

cyclopropylsulfonyl;

1-cyano-1-methyl-ethyl;

2-cyano-ethyl;

1-cyano-ethyl;

2-cyano-2-methyl-propyl;

1-(2,2,2-trifluoroethyl)piperidin-4-yl;

1-(methylsulfonyl)azetidin-3-yl;

(3-methyloxetan-3-yl)methyl;

(1S,5S)-8-oxabicyclo[3.2.1]octan-3-yl;

1-(oxetan-3-yl)piperidin-4-yl;

1-acetyl-piperidin-4-yl;

1-(cyclopropyl-carbonyl)-piperidin-4-yl;

1-methyl-piperidin-4-yl;

1-methyl-2-oxo-piperidin-5-yl;

2-oxo-piperidin-5-yl;

1-(isopropyl-carbonyl)-piperidin-4-yl;

1-(oxetan-3-yl)azetidin-3-yl;

1-(cyclopropyl-carbonyl)-piperidin-4-yl;

2-methoxycyclopentyl;

3-methoxycyclopentyl;

1-methoxy-2-methylpropan-2-yl;

tetrahydro-2H-1,1-dioxo-thiopyran-4-yl;

3-fluoro-1-(oxetan-3-yl)piperidin-4-yl;

1-methoxypropan-2-yl;

1-(2,2,2-trifluoroethyl)azetidin-3-yl);

1-(oxetan-3-yl)pyrrolidin-3-yl;

1-isopropylazetidin-3-yl;

3-fluoro-1-methylpiperidin-4-yl;

1-ethyl-3-fluoropiperidin-4-yl;

1-methylpyrrolidin-3-yl;

2-methoxyethyl)piperidin-4-yl);

1-methyl-1-(methylamino-carbonyl)-ethyl;

2-methyl-2-morpholino-propyl;

4,4-difluorocyclohexyl;

morpholin-4-yl-carbonyl;

dimethylamino-carbonyl-methyl;

methylamino-carbonyl-methyl;

1-methyl-1-(dimethylamino-carbonyl)-ethyl;

pyrrolidin-′

-yl-carbonyl;

1-cyamo-cyclopropyl;

1-(pyrrolidin-′

-yl-carbonyl)-ethyl;

1-(dimethylamino-carbonyl)-ethyl;

1-(methoxy-carbonyl)-ethyl;

1-(tert-butylamino-carbonyl)-1-methyl-ethyl;

1-(2,2,2-trifluoroethyllamino-carbonyl)-1-methyl-ethyl;

1-(ethylamino-carbonyl)-1-methyl-ethyl;

1-(cyclopropylmethylamino-carbonyl)-1-methyl-ethyl;

1-(ethylamino-carbonyl)-cyclobutyl;

1-(isopropylamino-carbonyl)-1-methyl-ethyl;

1-cyano-cyclobutyl;

2-methoxy-1-methyl-ethyl;

1-methyl-1-(methoxy-carbonyl)-ethyl;

2-methoxy-2-methyl-propan-1-yl;

1-(oxetan-3-yl)-pyrrolidin-3-yl;

isopropylsulfonyl;

butane-2-sulfonyl;

1-(2-fluoroethyl)-piperidin-4-yl;

3-fluoro-1-methyl-piperidin-4-yl;

1-ethyl-3-fluoro-piperidin-4-yl;

pyridin-3-ylmethyl;

6-methyl-pyridin-2-ylmethyl;

2-(morpholin-1-yl)-1,1,dimethyl-ethyl;

pyrimdin-2-yl-methyl;

3-fluoro-1-(oxetan-3-yl)-piperidin-4-yl;

1-(oxetan-3-yl)-piperidin-3-yl;

1-([1,3]Dioxolan-2-ylmethyl)-piperidin-4-yl;

pyridazin-3-ylmethyl;

piperidin-3-yl;

pyrazin-2-ylmethyl;

2-hydroxy-3-methyl-butan-1-yl;

1-([1,3]Dioxolan-2-ylmethyl)-pyrrolidin-3-yl;

pyrimidin-4-ylmethyl;

1-methyl-1H-pyrazol-3-ylmethyl;

1-methyl-1-(4H-[1,2,4]triazol-3-yl)-ethyl;

1-methyl-1-(5-methyl-4H[1,2,4]triazol-3-yl)-ethyl;

3-fluoro-piperidin-4-yl;

2-hydroxy-cyclopentyl;

dimethyl-[1,3]dioxan-5-yl;

2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-yl;

2-(4-methyl-4H-1,2,4-triazol-3-yl)propan-2-yl;

2-(1-methyl-1H-1,2,4-triazol-3-yl)propan-2-yl;

2-(1-methyl-1H-pyrazol-4-yl)propan-2-yl;

2-(1-methyl-1H-pyrazol-3-yl)propan-2-yl;

2-(1-methyl-1H-pyrazol-5-yl;

2-(4H-1,2,4-triazol-3-yl)propan-2-yl;

or 1-methyl-1H-pyrazole-4-yl.

17. The compound of claim 15, wherein R⁵ is hydrogen or methyl.

21. The compound of claim 15, wherein R⁵ is hydrogen, and R³ is:

C_1-6alkyl;

halo-C_1-6alkyl;

hydroxy-C_1-6alkyl;

cyano-C_1-6alkyl;

C_3-6cycloalkyl;

C_3-6cycloalkyl-C_1-6alkyl;

heterocyclyl optionally substituted one or more times with R⁷;

or heterocyclyl-C_1-6alkyl wherein the heterocyclyl portion is optionally substituted one or more times with R⁷, wherein the heterocyclyl is piperidinyl, pyrrolidinyl, oxetanyl, tetrahydropyranyl, tetrahydrofuranyl, azetidinyl, [1,3]dioxolanyl or tetrahydrothiopyranyl.

22. The compound of claim 21, wherein R³ is cyano-C_1-6alkyl.

18. A compound selected from:

N²-(1-isopropyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N²-(1,5-dimethyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N⁴-methyl-N²-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N⁴-methyl-N²-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-chloro-N²-(1-isopropyl-1H-pyrazol-4-yl)-N⁴-methylpyrimidine-2,4-diamine;

N⁴-methyl-N²-(1-methyl-1H-pyrazol-5-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N⁴-methyl-N²-(1-methyl-1H-pyrazol-3-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N²-(1,3-dimethyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-N-(1,5-dimethyl-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)pyrimidin-2-amine;

N⁴-methyl-5-(trifluoromethyl)-N²-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-Chloro-N-(1-isopropyl-1H-pyrazol-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)pyrimidin-2-amine;

5-Chloro-N-(1,5-dimethyl-1H-pyrazol-4-yl)-4-methoxypyrimidin-2-amine;

N-(1,5-dimethyl-1H-pyrazol-4-yl)-4-(pyrrolidin-1-yl)-5-(trifluoromethyl)pyrimidin-2-amine;

N²-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-N-(1,3-dimethyl-1H-pyrazol-4-yl)-4-methoxypyrimidin-2-amine;

N⁴-methyl-N²-(3-methyl-1-(oxetan-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N²-(5-chloro-1-methyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-4-methoxy-N-(3-methyl-1-(oxetan-3-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine;

5-Chloro-4-methoxy-N-(1-(2-methoxyethyl)-3-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine;

5-chloro-4-methoxy-N-(1-(2-methoxyethyl)-5-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine;

5-Chloro-N-(5-chloro-1-methyl-1H-pyrazol-4-yl)-4-methoxypyrimidin-2-amine;

2-Methyl-1-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propan-2-ol;

2-Methyl-1-(3-methyl-4-(4-(methylamino)-5-chloro-pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propan-2-ol;

N²-(1-(2-methoxyethyl)-3-methyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N²-(1-(2-methoxyethyl)-5-methyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-N-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4-methoxypyrimidin-2-amine;

5-Chloro-N⁴-methyl-N²-(3-methyl-1-(oxetan-3-yl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

N²-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-N-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-4-methoxypyrimidin-2-amine;

5-Chloro-N²-(1,3-dimethyl-1H-pyrazol-4-yl)-N⁴-methylpyrimidine-2,4-diamine;

5-Chloro-N²-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-N⁴-methylpyrimidine-2,4-diamine;

N⁴-methyl-N²-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N⁴-methyl-N²-(5-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N²-(2-Ethyl-2H-pyrazol-3-yl)-5-fluoro-N⁴-methyl-pyrimidine-2,4-diamine;

5-Fluoro-N⁴-methyl-N²-(2-methyl-2H-pyrazol-3-yl)-pyrimidine-2,4-diamine;

5-Fluoro-N⁴-methyl-N⁴-(2-propyl-2H-pyrazol-3-yl)-pyrimidine-2,4-diamine;

N²-(2,5-Dimethyl-2H-pyrazol-3-yl)-5-fluoro-N⁴-methyl-pyrimidine-2,4-diamine;

N²-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxypyrimidin-2-amine;

N²-(3-Cyclopropyl-1-methyl-1H-pyrazol-5-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-N-(3-isopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxypyrimidin-2-amine;

5-Chloro-N²-(5-isopropyl-2-methyl-2H-pyrazol-3-yl)-N⁴-methyl-pyrimidine-2,4-diamine;

5-Chloro-4-methoxy-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrimidin-2-amine;

5-Chloro-N⁴-methyl-N²-(1,3,5-trimethyl-1H-pyrazol-4-yl)-pyrimidine-2,4-diamine;

5-Chloro-N²-(5-cyclopropyl-2-methyl-2H-pyrazol-3-yl)-N⁴-methyl-pyrimidine-2,4-diamine;

N⁴-Methyl-N²-(5-methyl-1-oxetan-3-yl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N²-(1-isopropyl-1H-pyrazol-5-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-N-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-4-methoxypyrimidin-2-amine;

5-Chloro-N²-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-N⁴-methylpyrimidine-2,4-diamine;

N²-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-Chloro-N²-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-N⁴-methylpyrimidine-2,4-diamine;

5-chloro-N²-(1-isopropyl-1H-pyrazol-5-yl)-N⁴-methylpyrimidine-2,4-diamine;

5-chloro-N-(1-isopropyl-1H-pyrazol-5-yl)-4-methoxypyrimidin-2-amine;

5-chloro-4-methoxy-N-(3-methyl-1-(methylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-2-amine;

N²-(1-ethyl-1H-pyrazol-3-yl)-N⁴-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-chloro-4-methoxy-N-(5-methyl-1-phenyl-1H-pyrazol-4-yl)pyrimidin-2-amine;

N²-(1-isopropyl-1H-pyrazol-3-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N⁴-methyl-N²-(5-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N²-(1-(2,2-dimethyl-1,3-dioxan-5-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-chloro-4-methoxy-N-(5-methyl-1-(4-(methylsulfonyl)phenyl)-1H-pyrazol-4-yl)pyrimidin-2-amine;

N⁴-ethyl-N²-(1-methyl-1H-pyrazol-3-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-chloro-N-(1,5-dimethyl-1H-pyrazol-4-yl)-4-(oxetan-3-yloxy)pyrimidin-2-amine;

5-chloro-4-(2,2-difluoroethoxy)-N-(1,5-dimethyl-1H-pyrazol-4-yl)pyrimidin-2-amine;

5-chloro-N-(1,5-dimethyl-1H-pyrazol-4-yl)-4-(2,2,2-trifluoroethoxy)pyrimidin-2-amine;

5-chloro-4-methoxy-N-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine;

(4-(4-(5-chloro-4-methoxypyrimidin-2-ylamino)-3-methyl-1H-pyrazol-1-yl)piperidin-1-yl)(1-methylcyclopropyl)methanone;

(4-(4-(5-chloro-4-methoxypyrimidin-2-ylamino)-5-methyl-1H-pyrazol-1-yl)piperidin-1-yl)(1-methylcyclopropyl)methanone;

4-(4-(5-chloro-4-methoxypyrimidin-2-ylamino)-3-methyl-1H-pyrazol-1-yl)benzonitrile;

5-chloro-4-methoxy-N-(3-methyl-1-(3-methylpyridin-4-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine;

5-chloro-N-(1-(cyclopropylsulfonyl)-5-methyl-1H-pyrazol-4-yl)-4-methoxypyrimidin-2-amine;

5-chloro-N-(1-(cyclopropylsulfonyl)-3-methyl-1H-pyrazol-4-yl)-4-methoxypyrimidin-2-amine;

2-(4-(5-chloro-4-methoxypyrimidin-2-ylamino)-5-methyl-1H-pyrazol-1-yl)-2-methylpropanenitrile;

2-(4-(5-chloro-4-methoxypyrimidin-2-ylamino)-3-methyl-1H-pyrazol-1-yl)-2-methylpropanenitrile;

5-chloro-4-ethoxy-N-(5-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)pyrimidin-2-amine;

(5-Chloro-4-methoxy-pyrimidin-2-yl)-[1-(4-methanesulfonyl-phenyl)-3-methyl-1H-pyrazol-4-yl]-amine;

(5-Chloro-4-methoxy-pyrimidin-2-yl)-(3-methyl-1-phenyl-1H-pyrazol-4-yl)-amine;

(4-Methoxy-5-trifluoromethyl-pyrimidin-2-yl)-(3-methyl-1-phenyl-1H-pyrazol-4-yl)-amine;

(4-Methoxy-5-trifluoromethyl-pyrimidin-2-yl)-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-amine;

(5-Chloro-4-methoxy-pyrimidin-2-yl)-(1-methanesulfonyl-3-methyl-1H-pyrazol-4-yl)-amine;

(5-Chloro-4-methoxy-pyrimidin-2-yl)-[5-methyl-1-(tetrahydro-pyran-4-yl)-1H-pyrazol-4-yl]-amine;

4-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-N,N-dimethyl-benzamide;

4-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-5-methyl-pyrazol-1-yl]-N,N-dimethyl-benzamide;

4-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-5-methyl-pyrazol-1-yl]-benzonitrile;

N²-(5-Methoxy-1-methyl-1H-pyrazol-4-yl)-N⁴-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

(5-Chloro-4-methoxy-pyrimidin-2-yl)-[5-chloro-1-(tetrahydro-pyran-4-yl)-1H-pyrazol-4-yl]-amine;

(5-Chloro-4-methoxy-pyrimidin-2-yl)-{1-[1-(2-fluoro-ethyl)-piperidin-4-yl]-3-methyl-1H-pyrazol-4-yl}-amine;

N²-[1-(1-[1,3]Dioxolan-2-ylmethyl-piperidin-4-yl)-5-methyl-1H-pyrazol-4-yl]-N⁴-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N²-[1-(1-[1,3]Dioxolan-2-ylmethyl-piperidin-4-yl)-3-methyl-1H-pyrazol-4-yl]-N⁴-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

5-bromo-N²-(1,5-dimethyl-1H-pyrazol-4-yl)-N⁴-methylpyrimidine-2,4-diamine;

N²-(1,3-Dimethyl-1H-pyrazol-4-yl)-5-iodo-N⁴-methyl-pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(5-methyl-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(3-methyl-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(5-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-(oxetan-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-chloro-N4-ethyl-N2-(3-methyl-1-(oxetan-3-yl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(1-methyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine;

2-methyl-1-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propan-2-ol;

5-chloro-N4-methyl-N2-(3-methyl-1-(methylsulfonyl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(methylsulfonyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-bromo-N4-ethyl-N2-(3-methyl-1-(oxetan-3-yl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

N2-(1-(difluoromethyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(difluoromethyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-bromo-N4-ethyl-N2-(1-ethyl-5-methyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-bromo-N2-(1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl)-N4-methylpyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(3-methyl-1-phenyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(1-methyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(1-(methylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-bromo-N4-methyl-N2-(3-methyl-1-propyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-chloro-N4-methyl-N2-(3-methyl-1-methyloxetan-3-yl)methyl)-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-bromo-N2-(1-(3,5-difluorophenyl)-5-methyl-1H-pyrazol-4-yl)-N4-methylpyrimidine-2,4-diamine;

5-bromo-N2-(1-(3,5-difluorophenyl)-3-methyl-1H-pyrazol-4-yl)-N4-methylpyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(pyridin-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-((3-methyloxetan-3-yl)methyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-propyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-propyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-bromo-N2-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)-N4-methylpyrimidine-2,4-diamine;

5-bromo-N2-(1-(4-chlorophenyl)-5-methyl-1H-pyrazol-4-yl)-N4-methylpyrimidine-2,4-diamine;

N2-(1-(4-chlorophenyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(4-(methylsulfonyl)phenyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(4-(methylsulfonyl)phenyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-((1S,5S)-8-oxabicyclo[3.2.1]octan-3-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-butyl-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(pyrimidin-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(2-fluoroethyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(2-fluoroethyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

1-(4-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3-methyl-1H-pyrazol-1-yl)piperidin-1-yl)ethanone;

Cyclopropyl(4-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidin-1-yl)methanone;

Cyclopropyl(4-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidin-1-yl)methanone;

1-(4-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5-methyl-1H-pyrazol-1-yl)piperidin-1-yl)ethanone;

N2-(5-chloro-1-isopropyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-chloro-1-ethyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(pyrimidin-5-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(4-methyl-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(2-methylpyridin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(2-methylpyridin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-((3-methyloxetan-3-yl)methyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-chloro-1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

4-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)benzonitrile;

4-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)benzonitrile;

N4-methyl-N2-(3-methyl-1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5-methyl-1H-pyrazol-1-yl)-1-methylpiperidin-2-one;

5-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3-methyl-1H-pyrazol-1-yl)-1-methylpiperidin-2-one;

5-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidin-2-one;

5-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidin-2-one;

N2-(1-isopropyl-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N,N-dimethyl-4-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)benzamide;

4-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5-methyl-1H-pyrazol-1-yl)-N,N-dimethylbenzamide;

N4-ethyl-N2-(5-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-(methylsulfonyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(4-(cyclopropylsulfonyl)phenyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

4-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5-methyl-1H-pyrazol-1-yl)benzonitrile;

N4-ethyl-N2-(5-methyl-1-(4-(methylsulfonyl)phenyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N,N-dimethyl-4-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)benzamide;

N2-(1-(cyclopropylmethyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(cyclopropylmethyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(4-(cyclopropylsulfonyl)phenyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-chloro-1-(oxetan-3-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(5-methyl-1-((3-methyloxetan-3-yl)methyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(cyclopropylsulfonyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(cyclopropylsulfonyl)-3-methyl-1H-pyrazol-4-yl)-N4-ethyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

5-chloro-N4-(2,2-difluoroethyl)-N2-(1,5-dimethyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

5-chloro-4-methyl-N-(3-methyl-1-(4-(methylsulfonyl)phenyl)-1H-pyrazol-4-yl)pyrimidin-2-amine;

N2-(1-(4-(cyclopropylsulfonyl)phenyl)-5-methyl-1H-pyrazol-4-yl)-N4-ethyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

2-methyl-1-(4-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidin-1-yl)propan-1-one;

N4-ethyl-N2-(1-methyl-1H-pyrazol-5-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(3-cyclopropyl-1-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-cyclopropyl-1-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-((3-methyloxetan-3-yl)methyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-chloro-1-((3-methyloxetan-3-yl)methyl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

1-(4-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5-methyl-1H-pyrazol-1-yl)piperidin-1-yl)-2-methylpropan-1-one;

N4-ethyl-N2-(3-methyl-1-(1-(oxetan-3-yl)azetidin-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

Cyclopropyl(4-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3-methyl-1H-pyrazol-1-yl)piperidin-1-yl)methanone;

Cyclopropyl(4-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5-methyl-1H-pyrazol-1-yl)piperidin-1-yl)methanone;

1-(5-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol;

N4-ethyl-N2-(1-ethyl-1H-pyrazol-3-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(S)—

N2-(1-(2-methoxypropyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(2-methoxycyclopentyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(S)—

N2-(1-(2-methoxypropyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(1-methoxy-2-methylpropan-2-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(2,6-dimethyltetrahydro-2H-pyran-4-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(R)—

N2-(1-(2-methoxypropyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(3-methoxycyclopentyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(1-methyl-5-(methylamino)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(methylsulfonyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(tetrahydro-2H-1,1-dioxo-thiopyran-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

2-methyl-1-(4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5-(trifluoromethyl)-1H-pyrazol-1-yl)propan-2-ol;

2-methyl-1-(4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-2-ol;

N2-(1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(R)—

N2-(1-(1-methoxypropan-2-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

1-(3-tert-butyl-4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol;

N4-methyl-N2-(3-methyl-1-(1-(2,2,2-trifluoroethyl)azetidin-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(1-methoxy-2-methylpropan-2-yl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(R)—

N4-methyl-N2-(3-methyl-1-(1-(oxetan-3-yl)pyrrolidin-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(R)—

N2-(1-(1-methoxypropan-2-yl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(4-methyl-1H-pyrazol-5-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(5-methyl-1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(R)—

N4-methyl-N2-(5-methyl-1-(1-(oxetan-3-yl)pyrrolidin-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(1-isopropylazetidin-3-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

1-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazole-5-carbonitrile;

N4-ethyl-N2-(1-(isopropylsulfonyl)-3-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(isopropylsulfonyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(isopropylsulfonyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(sec-butylsulfonyl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(sec-butylsulfonyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

1-(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3-isopropyl-1H-pyrazol-1-yl)-2-methylpropan-2-ol;

N2-(1-(3-fluoro-1-methylpiperidin-4-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-isopropyl-1-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(1-(pyridin-2-yl)ethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(1-(pyridin-2-yl)ethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(3-isopropyl-1-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(3-cyclobutyl-1-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-cyclobutyl-1-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1,5-dimethyl-1H-pyrazol-4-yl)-N4-((tetrahydro-2H-pyran-4-yl)methyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(R)—

N4-methyl-N2-(3-methyl-1-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

1-(5-chloro-4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol;

1-(3-cyclopropyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol;

1-(3-cyclopropyl-4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol;

2-(5-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-N,2-dimethylpropanamide;

N2-(1-(1-(2-methoxyethyl)piperidin-4-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(1-(2-methoxyethyl)piperidin-4-yl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

(R)—

N4-methyl-N2-(5-methyl-1-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-chloro-1-(3-fluoro-1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-chloro-1-(1-ethyl-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(1-(ethylsulfonyl)-3-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(1-(ethylsulfonyl)-5-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(2-methyl-2-morpholinopropyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(1-ethyl-3-fluoropiperidin-4-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(5-(dimethylamino)-1-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

2-(5-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropan-1-ol;

N²-(1-(ethylsulfonyl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

2-Methyl-1-[3-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-propan-2-ol;

N2-[1-(2-Methoxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-(2-Methoxy-ethyl)-5-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

5-Bromo-N2-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-N4-methyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-[3-methyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

5-Bromo-N2-(1-difluoromethyl-5-methyl-1H-pyrazol-4-yl)-N4-methyl-pyrimidine-2,4-diamine;

5-Bromo-N2-(1-difluoromethyl-3-methyl-1H-pyrazol-4-yl)-N4-methyl-pyrimidine-2,4-diamine;

5-Bromo-N2-(1,5-dimethyl-1H-pyrazol-4-yl)-N4-ethyl-pyrimidine-2,4-diamine;

5-Bromo-N2-[1-(4-fluoro-phenyl)-5-methyl-1H-pyrazol-4-yl]-N4-methyl-pyrimidine-2,4-diamine;

5-Bromo-N4-methyl-N2-(5-methyl-1-propyl-1H-pyrazol-4-yl)-pyrimidine-2,4-diamine;

5-Bromo-N2-[1-(4-chloro-phenyl)-3-methyl-1H-pyrazol-4-yl]-N4-methyl-pyrimidine-2,4-diamine;

N2-(1,5-Dimethyl-1H-pyrazol-4-yl)-N4-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

5-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-piperidin-2-one;

4-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-N,N-dimethyl-benzamide;

N2-[1-(4-Cyclopropanesulfonyl-phenyl)-3-methyl-1H-pyrazol-4-yl]-N4-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

4-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-benzonitrile;

N4-Ethyl-N2-[1-(4-methanesulfonyl-phenyl)-3-methyl-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

1-{4-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-5-methyl-pyrazol-1-yl]-piperidin-1-yl}-2-methyl-propan-1-one;

1-{4-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-piperidin-1-yl}-2-methyl-propan-1-one;

N4-Methyl-N2-[3-methyl-1-(3-methyl-pyridin-4-yl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-((R)-2-Methoxy-propyl)-3-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-(2,6-Dimethyl-tetrahydro-pyran-4-yl)-5-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-(1,1-Dioxo-hexahydro-1$1%6&

-thiopyran-4-yl)-3-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-((R)-2-Methoxy-1-methyl-ethyl)-5-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-((S)-2-Methoxy-1-methyl-ethyl)-3-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-[3-methyl-1-((S)-1-oxetan-3-yl-pyrrolidin-3-yl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-[5-methyl-1-((S)-1-oxetan-3-yl-pyrrolidin-3-yl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-(1-Isopropyl-azetidin-3-yl)-5-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-[5-methyl-1-(propane-2-sulfonyl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-(5-Cyclobutyl-1-methyl-1H-pyrazol-4-yl)-N4-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-(3-Cyclobutyl-1-methyl-1H-pyrazol-4-yl)-N4-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-{1-[1-(2-methoxy-ethyl)-piperidin-4-yl]-3-methyl-1H-pyrazol-4-yl}-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-{1-[1-(2-methoxy-ethyl)-piperidin-4-yl]-5-methyl-1H-pyrazol-4-yl}-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-{1-[1-(2-Fluoro-ethyl)-piperidin-4-yl]-5-methyl-1H-pyrazol-4-yl}-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-{1-[1-(2-Fluoro-ethyl)-piperidin-4-yl]-3-methyl-1H-pyrazol-4-yl}-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[5-Chloro-1-(3-fluoro-1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-(1-Ethanesulfonyl-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-[5-methyl-1-(2-methyl-2-morpholin-4-yl-propyl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(3-methyl-1-pyridin-3-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-(1-Cyclopropanesulfonyl-3-cyclopropyl-1H-pyrazol-4-yl)-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(5-methyl-1-pyridin-3-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

(5-Chloro-4-methoxy-pyrimidin-2-yl)-{1-[1-(2-fluoro-ethyl)-piperidin-4-yl]-5-methyl-1H-pyrazol-4-yl}-amine;

N4-Methyl-N2-[3-methyl-1-(6-methyl-pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-[1-(2-methoxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-[1-(2-methoxy-ethyl)-5-methyl-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

1-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-5-methyl-pyrazol-1-yl]-2-methyl-propan-2-ol;

1-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-2-methyl-propan-2-ol;

N2-[1-(1,1-Dimethyl-2-morpholin-4-yl-ethyl)-3-methyl-1H-pyrazol-4-yl]-N4-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-(1,1-Dimethyl-2-morpholin-4-yl-ethyl)-3-methyl-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Cyclopropyl-N2-(1-methanesulfonyl-3-methyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Cyclopropyl-N2-(1-methanesulfonyl-5-methyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

1-[3-Chloro-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-2-methyl-propan-2-ol;

2-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-N-methyl-isobutyramide;

N4-Methyl-N2-(3-methyl-1-pyrimidin-2-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[5-Chloro-1-(3-fluoro-1-oxetan-3-yl-piperidin-4-yl)-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[5-Chloro-1-(3-fluoro-1-oxetan-3-yl-piperidin-4-yl)-1H-pyrazol-4-yl]-N4-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-[5-methyl-1-((S)-1-oxetan-3-yl-piperidin-3-yl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-[3-methyl-1-((S)-1-oxetan-3-yl-piperidin-3-yl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(5-methyl-1-pyridazin-3-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(3-methyl-1-pyridazin-3-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-[5-methyl-1-((S)-1-methyl-piperidin-3-yl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-[3-methyl-1-((S)-1-methyl-piperidin-3-yl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

3-[5-Chloro-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-2,2-dimethyl-propionitrile;

N4-Methyl-N2-[5-methyl-1-(6-methyl-pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(5-methyl-1-pyrimidin-2-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(5-methyl-1-pyrazin-2-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(3-methyl-1-pyrazin-2-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

3-[5-Chloro-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-2,2-dimethyl-propionitrile;

N4-Ethyl-N2-[1-(3-fluoro-1-oxetan-3-yl-piperidin-4-yl)-3-methyl-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

3-Methyl-1-[5-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-butan-2-ol;

3-Methyl-1-[3-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-butan-2-ol;

N2-[1-(1-[1,3]Dioxolan-2-ylmethyl-pyrrolidin-3-yl)-3-methyl-1H-pyrazol-4-yl]-N4-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(5-methyl-1-pyrimidin-4-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-[5-methyl-1-(1-methyl-1H-pyrazol-3-ylmethyl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-[3-methyl-1-(1-methyl-1H-pyrazol-3-ylmethyl)-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

3-[3-Chloro-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-2,2-dimethyl-propionitrile;

N4-Ethyl-N2-{3-methyl-1-[1-methyl-1-(4H-[1,2,4]triazol-3-yl)-ethyl]-1H-pyrazol-4-yl}-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-[1-(1-[1,3]Dioxolan-2-ylmethyl-pyrrolidin-3-yl)-5-methyl-1H-pyrazol-4-yl]-N4-ethyl-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-(3-methyl-1-pyrimidin-4-ylmethyl-1H-pyrazol-4-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine;

N2-(5-Fluoromethyl-1-methyl-1H-pyrazol-4-yl)-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine

N4-Ethyl-N2-{3-methyl-1-[1-methyl-1-(5-methyl-4H-[1,2,4]triazol-3-yl)-ethyl]-1H-pyrazol-4-yl}-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Methyl-N2-{3-methyl-1-[1-methyl-1-(4H-[1,2,4]triazol-3-yl)-ethyl]-1H-pyrazol-4-yl}-5-trifluoromethyl-pyrimidine-2,4-diamine;

N4-Ethyl-N2-[1-(3-fluoro-piperidin-4-yl)-3-methyl-1H-pyrazol-4-yl]-5-trifluoromethyl-pyrimidine-2,4-diamine;

2-[5-Methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-cyclopentanol;

2-[3-Methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-cyclopentanol;

N4-ethyl-N2-(3-methyl-1-(2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-(2-(4-methyl-4H-1,2,4-triazol-3-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-(2-(1-methyl-1H-1,2,4-triazol-3-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(2-(1-methyl-1H-pyrazol-4-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(5-methyl-1-(2-(1-methyl-1H-pyrazol-4-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-(2-(1-methyl-1H-pyrazol-3-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-ethyl-N2-(3-methyl-1-(2-(1-methyl-1H-pyrazol-5-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(2-(1-methyl-1H-pyrazol-5-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N4-methyl-N2-(3-methyl-1-(2-(1-methyl-1H-pyrazol-3-yl)propan-2-yl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1′

,5-dimethyl-1′

H-1,4′

-bipyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1′

,3-dimethyl-1′

H-1,4′

-bipyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

N2-(1-(2-(4H-1,2,4-triazol-3-yl)propan-2-yl)-3-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;

2-(1,5-dimethyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1,3-Dimethyl-1H-pyrazol-4-ylamino)-4-methylamino-pyrimidine-5-carbonitrile;

2-(1-ethyl-5-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-isopropyl-3-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-ethyl-3-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(3-methyl-1-phenyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(3-methyl-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(5-methyl-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(5-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(3-methyl-1-(2,2,2-trifluoro ethyl)-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(5-methyl-1-phenyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(5-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-ethyl-5-methyl-1H-pyrazol-4-ylamino)-4-(ethylamino)pyrimidine-5-carbonitrile;

2-(1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-(difluoromethyl)-3-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(5-methyl-1-propyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-(3,5-difluorophenyl)-3-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-(4-chlorophenyl)-5-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(3-methyl-1-(pyridin-2-yl)-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

4-(ethylamino)-2-(5-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-ylamino)pyrimidine-5-carbonitrile;

4-(ethylamino)-2-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-ylamino)pyrimidine-5-carbonitrile;

4-(ethylamino)-2-(3-methyl-1-(oxetan-3-yl)-1H-pyrazol-4-ylamino)pyrimidine-5-carbonitrile;

2-(1-isopropyl-5-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1,5-dimethyl-1H-pyrazol-4-ylamino)-4-methoxypyrimidine-5-carbonitrile;

2-(1,5-dimethyl-1H-pyrazol-4-ylamino)-4-(2,2,2-trifluoroethylamino)pyrimidine-5-carbonitrile;

2-(1-ethyl-5-methyl-1H-pyrazol-4-ylamino)-4-methoxypyrimidine-5-carbonitrile;

4-(2,2-difluoroethylamino)-2-(1,5-dimethyl-1H-pyrazol-4-ylamino)pyrimidine-5-carbonitrile;

2-(1,5-dimethyl-1H-pyrazol-4-ylamino)-4-(2,2,2-trifluoroethoxy)pyrimidine-5-carbonitrile;

2-(1-(cyclopropylmethyl)-3-methyl-1H-pyrazol-4-ylamino)-4-(methylamino)pyrimidine-5-carbonitrile;

2-(1-(4,4-difluorocyclohexyl)-5-methyl-1H-pyrazol-4-ylamino)-4-(methylamino) pyrimidine-5-carbonitrile;

2-(3-methyl-1-(oxetan-3-yl)-1H-pyrazol-4-ylamino)-4-(2,2,2-trifluoro ethylamino)pyrimidine-5-carbonitrile;

2-(5-chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-ylamino)-4-(methylamino) pyrimidine-5-carbonitrile;

2-(1-Difluoromethyl-5-methyl-1H-pyrazol-4-ylamino)-4-methylamino-pyrimidine-5-carbonitrile;

2-(1,5-Dimethyl-1H-pyrazol-4-ylamino)-4-ethylamino-pyrimidine-5-carbonitrile

2-[1-(4-Fluoro-phenyl)-5-methyl-1H-pyrazol-4-ylamino]-4-methylamino-pyrimidine-5-carbonitrile;

4-Methylamino-2-(3-methyl-1-propyl-1H-pyrazol-4-ylamino)-pyrimidine-5-carbonitrile;

4-Methylamino-2-(5-methyl-1-oxetan-3-yl-1H-pyrazol-4-ylamino)-pyrimidine-5-carbonitrile;

4-Methylamino-2-(3-methyl-1-oxetan-3-yl-1H-pyrazol-4-ylamino)-pyrimidine-5-carbonitrile;

2-[1-(3,5-Difluoro-phenyl)-5-methyl-1H-pyrazol-4-ylamino]-4-methylamino-pyrimidine-5-carbonitrile;

4-(2,2-Difluoro-ethoxy)-2-(1,5-dimethyl-1H-pyrazol-4-ylamino)-pyrimidine-5-carbonitrile;

2-[1-(4,4-Difluoro-cyclohexyl)-3-methyl-1H-pyrazol-4-ylamino]-4-methylamino-pyrimidine-5-carbonitrile;

(5-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-1-methyl-1H-pyrazol-3-yl)(morpholino)methanone;

2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;

N,N-dimethyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)acetamide;

N,N-dimethyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)acetamide;

N-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)acetamide;

N-methyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)acetamide;

N,N,2-trimethyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

2-methyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-1-(pyrrolidin-1-yl)propan-1-one;

2-methyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;

1-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)cyclopropanecarbonitrile;

(R)-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-1-(pyrrolidin-1-yl)propan-1-one;

(R)—

N,N-dimethyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

(S)-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-1-(pyrrolidin-1-yl)propan-1-one;

3-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;

3-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;

methyl 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanoate;

methyl 2-methyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanoate;

2-(3-ethyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropanenitrile;

(R)-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-1-(pyrrolidin-1-yl)propan-1-one;

(R)—

N,N-dimethyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

(S)-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-1-(pyrrolidin-1-yl)propan-1-one;

(S)—

N,N-dimethyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

(S)-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;

(S)-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;

2-(4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-3-methyl-1H-pyrazol-1-yl)-2-methylpropanenitrile;

2-(5-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropanenitrile;

2-(3-cyclopropyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropanenitrile;

2,2-dimethyl-3-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;

2,2-dimethyl-3-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;

1-(5-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)cyclopropanecarbonitrile;

N-tert-butyl-2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-N-(2,2,2-trifluoroethyl)propanamide;

2-(5-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-N-ethyl-2-methylpropanamide;

N-(cyclopropylmethyl)-2-methyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

N-(cyclopropylmethyl)-2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

N-ethyl-1-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)cyclobutanecarboxamide;

N-isopropyl-2-methyl-2-(5-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

1-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)cyclobutanecarbonitrile;

2-(4-(4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3-methyl-1H-pyrazol-1-yl)-2-methylpropanenitrile;

N,2-dimethyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanamide;

1-(5-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)cyclopropanecarbonitrile;

2-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-5-methyl-pyrazol-1-yl]-2-methyl-propionic acid methyl ester;

2-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-2-methyl-propionic acid methyl ester;

(S)—

N,N-Dimethyl-2-[3-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-propionamide;

R)-2-[3-Methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-propionitrile;

2-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-3-cyclopropyl-pyrazol-1-yl]-2-methyl-propionitrile;

(R)-2-[5-Methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-propionitrile;

N-Ethyl-2-[3-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-isobutyramide;

N-Ethyl-2-[5-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-isobutyramide;

1-[5-Methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-cyclobutanecarboxylic acid ethylamide;

2-[5-Methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-N-(2,2,2-trifluoro-ethyl)-isobutyramide;

N-Isopropyl-2-[3-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-isobutyramide;

N-Methyl-2-[5-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-isobutyramide;

1-[5-Methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-cyclobutanecarbonitrile;

N-tert-Butyl-2-[5-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-pyrazol-1-yl]-isobutyramide;

2-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-5-methyl-pyrazol-1-yl]-N-methyl-isobutyramide;

2-[4-(4-Cyclopropylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-N-methyl-isobutyramide;

2-[4-(4-Cyclopropylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-5-methyl-pyrazol-1-yl]-N-methyl-isobutyramide;

2-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-2-methyl-propionitrile;

2-(3-chloro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)-2-methylpropanenitrile; and

2-[4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methyl-pyrazol-1-yl]-N-methyl-isobutyramide.

19. The compound N2-[5-chloro-1-(3-fluoro-1-oxetan-3-yl-piperidin-4-yl)-1H-pyrazol-4-yl]-N4-methyl-5-trifluoromethyl-pyrimidine-2,4-diamine, or a pharmaceutical salt thereof.

20. The compound 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile, or a pharmaceutical salt thereof.