Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)

• US 8,821,801 B2
• Filed: 08/16/2012
• Issued: 09/02/2014
• Est. Priority Date: 08/18/2004
• Status: Active Grant

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Rounbehler, David R., Fine, David H.
• Primary Examiner(s): BHAT, NINA NMN
• Application Number:
  US13/587,543
• Publication Number:
  US 20130037023A1
• Time in Patent Office: 747 Days
• Field of Search: 422/120, 422/122, 422/112, 128/200.24, 128/203.12, 951/02, 961/54
• US Class Current: 422/120
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/122 with dilution
• CPC Class Codes: A61M 2016/1025 the O2 concentration
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

Claims

1. A system for delivering a therapeutic amount of nitric oxide, comprising:

a reservoir, wherein the reservoir includes a flow controller;

a gas supply; and

a delivery conduit including

at least one cartridge, wherein the at least one cartridge comprises a surface-active material and a reducing agent, and

a patient interface.

2. The system of claim 1, wherein the flow controller includes a tube.

3. The system of claim 2, wherein the tube is a narrow bore tube.

4. The system of claim 1, wherein the flow controller includes a first end coupled to the reservoir.

5. The system of claim 4, wherein the flow controller includes a second end coupled to the delivery conduit.

6. The system of claim 1, wherein the delivery conduit includes an inlet and an outlet.

7. The system of claim 1, wherein the gas supply is coupled to the delivery conduit.

8. The system of claim 6, wherein the gas supply is coupled to the inlet of the delivery conduit.

9. The system of claim 6, wherein the patient interface is coupled to the outlet of the delivery conduit.

10. The system of claim 1, wherein the reservoir includes a nitrogen dioxide source.

11. The system of claim 10, wherein the nitrogen dioxide source includes liquid dinitrogen tetroxide.

12. The system of claim 1, wherein the gas supply is an air supply.

13. The system of claim 12, wherein the air supply is an air pump.

14. The system of claim 5, wherein the gas supply is coupled to an inlet of the delivery conduit and wherein the second end of the restrictor is coupled to the delivery conduit.

15. The system of claim 1, wherein the system also includes at least one of a nitric oxide sensor, a nitrogen dioxide sensor, a flow sensor, a pressure sensor and a sensor for atmospheric pressure.

16. A reservoir assembly, comprising:

a reservoir, wherein the reservoir including a nitrogen dioxide source; and

a flow controller.

17. The reservoir assembly of claim 16, wherein the flow controller includes a tube.

18. The reservoir assembly of claim 17, wherein the tube is a narrow bore needle.

19. The reservoir assembly of claim 16, wherein the flow controller includes a first end and a second end, and the first end of the flow controller is coupled to the reservoir.

20. The reservoir assembly of claim 19, wherein the second end of the flow controller is sealed or closed.