Matrix-assisted laser desorption ionization mass spectrometry substrates having low volume matrix array elements
First Claim
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1. A substrate for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis, which comprises a surface having an array of spots, wherein:
- each spot comprises 3-hydroxypicolinic acid matrix and no analyte resulting from the deposition, by a vesicle or pin comprising an interior chamber and connected to a pressure source, of a reproduced, defined and controlled 0.2 to 20 nanoliter volume of matrix material;
the substrate is a flat chip; and
the center of each spot is about 2.25 millimeters or less from the center of an adjacent spot.
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Abstract
Provided herein are substrates for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis. Each spot includes 3-hydroxypicolinic acid matrix and no analyte.
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17 Claims
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1. A substrate for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis, which comprises a surface having an array of spots, wherein:
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each spot comprises 3-hydroxypicolinic acid matrix and no analyte resulting from the deposition, by a vesicle or pin comprising an interior chamber and connected to a pressure source, of a reproduced, defined and controlled 0.2 to 20 nanoliter volume of matrix material; the substrate is a flat chip; and the center of each spot is about 2.25 millimeters or less from the center of an adjacent spot. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification