Method and process for the production of multi-coated recognitive and releasing systems

• US 8,821,899 B2
• Filed: 12/04/2008
• Issued: 09/02/2014
• Est. Priority Date: 03/12/2007
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Peppas, Nicholas A., Ekerdt, Barbara, Gomez-Burgaz, Marta
• Primary Examiner(s): Claytor, Renee
• Assistant Examiner(s): Kantamneni, Shobha
• Application Number:
  US12/328,469
• Publication Number:
  US 20090232857A1
• Time in Patent Office: 2,098 Days
• Field of Search: 424/400, 424/464, 424/486, 424/487, 526/72
• US Class Current: 424/400
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 47/6903 the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/025 Explicitly spheroidal or spherical shape
• CPC Class Codes: A61K 8/0279 Porous; Hollow
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/5031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/5073 having two or more different coatings optionally including drug-containing subcoatings
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61K 9/7015 Drug-containing film-forming compositions, e.g. spray-on
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention includes compositions, methods, systems for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.

Claims

1. A composition comprising:

a molecule-imprinted polymeric network comprising

a polymer comprising acrylamide and ethylene glycol dimethacrylate imprinted with glucose molecule,

one or more pores in the polymer wherein the one or more pores are micropores or nanopores that recognize a glucose molecule;

one or more active agents in contact with the one or more pores and the polymer to form an active agent-load, molecule-imprinted polymeric network, wherein the one or more active agents comprise insulin, wherein subsequent contact with the glucose molecule creates internal stresses that rupture the polymeric network at the one or more pores,

wherein the molecule-imprinted polymeric network is encapsulated with at least one coating layer containing an active agent layer;

wherein rupture of the active agent-load, molecule-imprinted polymeric network is by at least one of;

osmosis upon recognition and binding of the glucose molecule leading to rupture due to swelling;

change of the solubility of the active agent-load, molecule-imprinted polymeric network leading to polymer dissolution;

or

local temperature changes leading to expansion of the active agent-load, molecule-imprinted polymeric network and combinations thereof.

2. The composition of claim 1, wherein the composition is encapsulated and comprises a surfactant, a bleaching agent, a corrosion inhibitor, a sudsing modifier, a fluorescent whitening agent, one or more enzymes, an anti redeposition agent, a color, one or more additives and combinations thereof.

3. The composition of claim 1, wherein the one or more active agents are released upon a change in solubility, pressure, a pH shift, a change in temperature, a temperature increase, enzymatic breakdown, diffusion and combinations thereof.

4. The composition of claim 1, wherein the molecule-imprinted polymeric network is formed into one or more layers to form a multilayer active agent-load, molecule-imprinted polymeric network.

5. The composition of claim 1, further comprising a second coating layer covering the active agent-load, molecule-imprinted polymeric network, wherein the second coating layer comprises a second polymer comprising one or more second pores in the second polymer that recognize a second molecule and subsequent contact with the second molecule creates internal stresses that rupture the second coating layer which provides a barrier to the release of one or more different active, one or more inert agents or both.

6. The composition of claim 1, wherein the molecule-imprinted polymeric network is formed into a sphere, film, planar, semi-spherical, cylinder, rod, hemispheres, conical, hemi-cylinders and combination thereof.

7. The composition of claim 1, wherein the molecule-imprinted polymeric network is at least partially porous.

8. An active agent-loaded, molecule-imprinted polymeric recognitive network composition comprising:

a molecule-imprinted polymeric network disposed about a polymer core comprising

one or more molecule imprinted coating layers independently comprising an acrylamide and ethylene glycol dimethacrylate polymer imprinted with one or more glucose molecules,

one or more pores in the acrylamide and ethylene glycol dimethacrylate polymer that recognize a glucose molecule wherein the one or more pores are micropores or nanopores;

one or more active agents in contact with the one or more pores to form an active agent-load, molecule-imprinted polymeric network, wherein the one or more active agents comprise insulin, wherein subsequent contact with the glucose molecule creates internal stresses that rupture the polymeric network at the one or more pores,

wherein the one or more molecule imprinted coating layers is encapsulated with at least one coating layer containing an active agent layer;

wherein rupture of the active agent-load, molecule-imprinted polymeric network is by at least one of;

osmosis upon recognition and binding of the glucose molecule leading to rupture due to swelling;

change of the solubility of the active agent-load, molecule-imprinted polymeric network leading to polymer dissolution;

or

local temperature changes leading to expansion of the active agent-load, molecule-imprinted polymeric network and combinations thereof.