Method and process for the production of multi-coated recognitive and releasing systems
First Claim
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1. A composition comprising:
- a molecule-imprinted polymeric network comprisinga polymer comprising acrylamide and ethylene glycol dimethacrylate imprinted with glucose molecule,one or more pores in the polymer wherein the one or more pores are micropores or nanopores that recognize a glucose molecule;
one or more active agents in contact with the one or more pores and the polymer to form an active agent-load, molecule-imprinted polymeric network, wherein the one or more active agents comprise insulin, wherein subsequent contact with the glucose molecule creates internal stresses that rupture the polymeric network at the one or more pores,wherein the molecule-imprinted polymeric network is encapsulated with at least one coating layer containing an active agent layer;
wherein rupture of the active agent-load, molecule-imprinted polymeric network is by at least one of;
osmosis upon recognition and binding of the glucose molecule leading to rupture due to swelling;
change of the solubility of the active agent-load, molecule-imprinted polymeric network leading to polymer dissolution;
orlocal temperature changes leading to expansion of the active agent-load, molecule-imprinted polymeric network and combinations thereof.
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Abstract
The present invention includes compositions, methods, systems for the controlled delivery of an active agent within a polymeric network upon the binding of a molecule that decreases the structural integrity of the polymeric network at one or more micro- or nanovacuoles.
22 Citations
8 Claims
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1. A composition comprising:
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a molecule-imprinted polymeric network comprising a polymer comprising acrylamide and ethylene glycol dimethacrylate imprinted with glucose molecule, one or more pores in the polymer wherein the one or more pores are micropores or nanopores that recognize a glucose molecule; one or more active agents in contact with the one or more pores and the polymer to form an active agent-load, molecule-imprinted polymeric network, wherein the one or more active agents comprise insulin, wherein subsequent contact with the glucose molecule creates internal stresses that rupture the polymeric network at the one or more pores, wherein the molecule-imprinted polymeric network is encapsulated with at least one coating layer containing an active agent layer; wherein rupture of the active agent-load, molecule-imprinted polymeric network is by at least one of; osmosis upon recognition and binding of the glucose molecule leading to rupture due to swelling; change of the solubility of the active agent-load, molecule-imprinted polymeric network leading to polymer dissolution;
orlocal temperature changes leading to expansion of the active agent-load, molecule-imprinted polymeric network and combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An active agent-loaded, molecule-imprinted polymeric recognitive network composition comprising:
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a molecule-imprinted polymeric network disposed about a polymer core comprising one or more molecule imprinted coating layers independently comprising an acrylamide and ethylene glycol dimethacrylate polymer imprinted with one or more glucose molecules, one or more pores in the acrylamide and ethylene glycol dimethacrylate polymer that recognize a glucose molecule wherein the one or more pores are micropores or nanopores; one or more active agents in contact with the one or more pores to form an active agent-load, molecule-imprinted polymeric network, wherein the one or more active agents comprise insulin, wherein subsequent contact with the glucose molecule creates internal stresses that rupture the polymeric network at the one or more pores, wherein the one or more molecule imprinted coating layers is encapsulated with at least one coating layer containing an active agent layer; wherein rupture of the active agent-load, molecule-imprinted polymeric network is by at least one of; osmosis upon recognition and binding of the glucose molecule leading to rupture due to swelling; change of the solubility of the active agent-load, molecule-imprinted polymeric network leading to polymer dissolution;
orlocal temperature changes leading to expansion of the active agent-load, molecule-imprinted polymeric network and combinations thereof.
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Specification