Systems and methods for ex vivo organ care
First Claim
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1. A method for perfusing a lung ex vivo, comprising:
- connecting the lung within a fluid perfusion circuit,flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface,providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen,ventilating the lung through a tracheal interface, andmeasuring a level of an arterial-venous (AV) oxygen gradient between the perfusion fluid flowing into the lung and flowing out of the lung,wherein the perfusion fluid flowing into the lung includes a first gas component at a substantially constant first composition, and the perfusion fluid flowing away from the lung includes the first gas component at a substantially constant second composition.
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Abstract
The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.
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Citations
54 Claims
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1. A method for perfusing a lung ex vivo, comprising:
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connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface, providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, ventilating the lung through a tracheal interface, and measuring a level of an arterial-venous (AV) oxygen gradient between the perfusion fluid flowing into the lung and flowing out of the lung, wherein the perfusion fluid flowing into the lung includes a first gas component at a substantially constant first composition, and the perfusion fluid flowing away from the lung includes the first gas component at a substantially constant second composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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48. A method for perfusing a lung ex vivo, comprising:
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connecting the ex vivo lung to a fluid perfusion circuit; flowing a perfusion fluid into the ex vivo lung through a pulmonary artery interface and away from the ex vivo lung through a pulmonary vein interface, the perfusion fluid having a gas component; providing a respiratory gas to a tracheal interface of the lung, wherein; the respiratory gas is provided to the lung in periodic breaths in alternating inspiration and expiration periods; the periodic breaths have a pre-determined volume and pressure of gas; the respiratory gas has a pre-determined composition of oxygen such that i) the gas component of the perfusion fluid flowing into the ex vivo lung is substantially constant over time at a first level, and ii) the gas component of the perfusion fluid flowing out of the ex vivo lung is substantially constant over time at a second level; and maintaining a pre-determined minimum positive end-expiratory pressure in the lung. - View Dependent Claims (49, 50, 51, 52, 53, 54)
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Specification