Active chemically-sensitive sensors with source follower amplifier
First Claim
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1. An apparatus, comprising:
- an array of sensors, a plurality of sensors in the array having outputs connected in common to an amplifier node, and each sensor in the plurality including;
a chemically-sensitive field effect transistor having a first conduction terminal, a second conduction terminal coupled to a first supply voltage conductor, and a sensor surface;
a first transistor having a first conduction terminal coupled to the first conduction terminal of the chemically-sensitive field effect transistor, a second conduction terminal coupled to a second supply voltage conductor, and a gate coupled to a bias voltage conductor; and
a second transistor having a gate coupled to a corresponding select voltage conductor, a first conduction terminal coupled to the first conduction terminal of the chemically-sensitive field effect transistor, and a second conduction terminal coupled to the amplifier node; and
an amplifier having an input connected to the amplifier node and an output coupled to an output conductor.
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Abstract
Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
388 Citations
11 Claims
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1. An apparatus, comprising:
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an array of sensors, a plurality of sensors in the array having outputs connected in common to an amplifier node, and each sensor in the plurality including; a chemically-sensitive field effect transistor having a first conduction terminal, a second conduction terminal coupled to a first supply voltage conductor, and a sensor surface; a first transistor having a first conduction terminal coupled to the first conduction terminal of the chemically-sensitive field effect transistor, a second conduction terminal coupled to a second supply voltage conductor, and a gate coupled to a bias voltage conductor; and a second transistor having a gate coupled to a corresponding select voltage conductor, a first conduction terminal coupled to the first conduction terminal of the chemically-sensitive field effect transistor, and a second conduction terminal coupled to the amplifier node; and an amplifier having an input connected to the amplifier node and an output coupled to an output conductor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification