Isoketal scavengers and mitigation of disorders involving oxidative injury

• US 8,822,542 B2
• Filed: 02/27/2009
• Issued: 09/02/2014
• Est. Priority Date: 10/20/2004
• Status: Active Grant

• Current Assignee: Vanderbilt University
• Original Assignee: Vanderbilt University
• Inventors: Roberts, L. Jackson II, Balser, Jeffrey R., Davies, Sean S., Amarnath, Venkataraman, Viswanathan, Prakash C.
• Primary Examiner(s): CLAYTOR, DEIRDRE RENEE
• Application Number:
  US12/395,464
• Publication Number:
  US 20120157501A1
• Time in Patent Office: 2,013 Days
• Field of Search: None
• US Class Current: 514/649
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system

Abstract

A method of treating and/or preventing oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.

Claims

1. A method of treating oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or a salicylamine compound wherein the compound is selected from the formula:

2. The method of claim 1, wherein the compound is at least one of a salicylamine compound, or a, tyrosine compound.

3. The method of claim 1, wherein the compound is chosen from:

4. The method of claim 1, wherein the compound is of the following formula:

5. The method of claim 1, wherein the compound is of the following formula:

6. A method of surpressing IsoK/NeuroK adduct formation in a patient in need thereof, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or a salicylamine compound wherein the compound is selected from the formula:

7. The method of claim 6, wherein the compound is at least one of a pyridoxamine, salicylamine, tyrosine compound.

8. The method of claim 6, wherein the compound is chosen from: