2'-O-modified RNA
First Claim
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1. A ribonucleoside, a ribonucleotide, or a derivative thereof having a protective group at the 2′
- -position, wherein the protective group is represented by the following Formula (I);
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Abstract
A 2′-modified ribonucleoside having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. A modified form of RNA having a halogen-substituted alkoxymethyl protective group exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2′-O-methyl modified nucleic acid.
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Citations
10 Claims
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1. A ribonucleoside, a ribonucleotide, or a derivative thereof having a protective group at the 2′
- -position, wherein the protective group is represented by the following Formula (I);
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- -position, wherein the protective group is represented by the following Formula (I);
Specification