Apparatus and method for thermal assisted desorption ionization systems
First Claim
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1. A device for analyzing an analyte comprising:
- a spectrometer configured for analyzing the analyte, with an entrance for accepting analyte ions and a detector for detecting analyzed analyte ions;
an atmospheric pressure source configured for generating ionizing species;
a supply adapted to one or more of generate heat, transfer heat, conduct heat and radiate heat; and
one or more mesh positioned between the source and the spectrometer, where the analyte is introduced on or near the one or more mesh, where the supply can one or more of generate heat, transfer heat, conduct heat and radiate heat to the analyte, where analyte molecules desorbed from the one or more mesh interact with the ionizing species generated by the source to form a plurality of analyte ions which enter the spectrometer and are analyzed.
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Abstract
The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.
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Citations
20 Claims
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1. A device for analyzing an analyte comprising:
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a spectrometer configured for analyzing the analyte, with an entrance for accepting analyte ions and a detector for detecting analyzed analyte ions; an atmospheric pressure source configured for generating ionizing species; a supply adapted to one or more of generate heat, transfer heat, conduct heat and radiate heat; and one or more mesh positioned between the source and the spectrometer, where the analyte is introduced on or near the one or more mesh, where the supply can one or more of generate heat, transfer heat, conduct heat and radiate heat to the analyte, where analyte molecules desorbed from the one or more mesh interact with the ionizing species generated by the source to form a plurality of analyte ions which enter the spectrometer and are analyzed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A device for derivatizing and analyzing an analyte comprising:
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a spectrometer for analyzing the analyte, where the spectrometer has an entrance; a source configured for generating ionizing species, where the source has a proximal end and a distal end, where the distal end is proximal to the spectrometer entrance; and one or more mesh positioned in the atmospheric pressure region, where the analyte and a derivatizing reagent are applied on a mesh, where the ionizing species generated by the source are directed at the mesh, where analyte molecules are desorbed from the mesh and form a plurality of analyte ions which enter the spectrometer. - View Dependent Claims (14, 15, 16)
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17. A device for analyzing an analyte comprising:
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an ion mobility spectrometer including an entrance and a detector; a source configured for generating ionizing species; a supply adapted to one or more of generate heat, transfer heat, conduct heat, radiate heat and apply an electric potential; and two or more mesh positioned between the source and the spectrometer, where the analyte is applied on or near a first mesh, where the supply can one or more of generate heat, transfer heat, conduct heat and radiate heat to the analyte to desorb molecules of the analyte, where molecules desorbed from the first mesh interact with the ionizing species generated by the source to form analyte ions. - View Dependent Claims (18, 19, 20)
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Specification