Systems, devices and methods relating to endocardial pacing for resynchronization

• US 8,825,155 B2
• Filed: 09/01/2011
• Issued: 09/02/2014
• Est. Priority Date: 12/20/2004
• Status: Active Grant

• Current Assignee: Newstim, Inc.
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhu, Qingsheng, Ortega, Daniel Felipe
• Primary Examiner(s): Gedeon, Brian T
• Application Number:
  US13/223,919
• Publication Number:
  US 20110319956A1
• Time in Patent Office: 1,097 Days
• Field of Search: None
• US Class Current: 607/9
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/0565 Electrode heads
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3625 External stimulators
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

Disclosed are certain methods, apparatus, and processor-readable mediums that may be used to treat a conduction abnormality of the heart. In one example, the apparatus includes an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery to a heart via electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including a first pulse for delivery via a first electrode; and a second pulse for delivery via a second electrode; and wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other.

Claims

1. An apparatus, comprising:

an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery to a heart via electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including;

a first pulse for delivery via a first electrode located near the septal region of the right ventricle of the heart near the His bundle; and

a second pulse for delivery via a second electrode located near the septal region of the right ventricle of the heart near the his bundle,

wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other; and

wherein the implantable pacing profile generator is configured to update an overlap duration of the first and second pulses using a measured effectiveness of a previous electrostimulation provided to the heart via the first and second electrodes located near the septal region of the right ventricle of the heart near the His bundle.

2. The apparatus of claim 1, wherein the implantable pacing profile generator is configured to use, as the measured effectiveness of the previous electrostimulation, information about one or more of:

a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput.

3. The apparatus of claim 1, wherein the first and second pulses are substantially identical in time and duration.

4. The apparatus of claim 1, further comprising an implantable lead assembly including the first electrode and the second electrode.

5. The apparatus of claim 1, wherein the pacing profile generator includes a wireless interface configured to receive a command to adjust one or more parameters of the pacing profile from an external device in response to monitored information indicative of one or more of:

a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput, wherein the one or more adjustable parameters include one or more of a pulse width, a pulse amplitude, or a timing offset between initiation or termination of respective pulses.

6. The apparatus of claim 1, comprising a measurement module configured to measure the effectiveness of the previous electrostimulation provided to the heart, the measured effectiveness including a function of a timing of stimulation of a late activation site of a left ventricle relative to the QRS width.

7. The apparatus of claim 1, wherein the implantable pacing profile generator is configured to generate the pulses of the specified pacing electrostimulation profile at an energy level that exceeds a capture threshold voltage level of the His bundle.

8. A method, comprising:

generating a specified pacing electrostimulation profile for delivery to a heart via first and second electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including;

a first pulse for delivery via the first electrode; and

a second pulse for delivery via the second electrode,

wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other;

assessing an effectiveness of an electrostimulation provided to the heart using the first and second electrodes according to the specified pacing electrostimulation profile, the assessing including identifying a function of a timing of stimulation of a late activation site of a left ventricle relative to the QRS width; and

updating, for a subsequent pacing electrostimulation profile, an energy of at least one of the first and second pulses using the assessed effectiveness.

9. The method of claim 8, wherein the assessing the effectiveness of the electrostimulation provided to the heart using the first and second electrodes includes monitoring one or more of a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput.

10. The method of claim 8, wherein the first and second pulses are substantially identical in time and duration.

11. The method of claim 8, comprising receiving, at an implantable medical device, a command to adjust one or more parameters of the pacing profile, the command provided from an external device using a wireless interface.

12. The method of claim 11, wherein the one or more adjustable parameters include one or more of a pulse width, a pulse amplitude, or a timing offset between initiation or termination of respective pulses.

13. The method of claim 8, comprising adjusting one or more of the adjustable parameters to improve at least one of:

a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput.

14. The method of claim 8, comprising updating, for the subsequent pacing electrostimulation profile, an overlap duration of the first and second pulses, using the assessed effectiveness.

15. The method of claim 8, wherein the updating the energy includes using a pacing voltage threshold that exceeds a His bundle capture threshold.

16. A processor-readable medium comprising instructions, which when executed by a processor included as a portion of an implantable medical device cause the implantable medical device to:

generate a specified pacing electrostimulation profile for delivery to a heart via first and second electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including;

a first pulse for delivery via the first electrode; and

a second pulse for delivery via the second electrode,

wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other;

assess an effectiveness of an electrostimulation provided to the heart using the first and second electrodes and using the specified pacing electrostimulation profile, the assessment including a function of a timing of stimulation of a late activation site of a left ventricle relative to the QRS width; and

update, for a subsequent pacing electrostimulation profile, an overlap duration of the first and second pulses using the assessed effectiveness.

17. The processor-readable medium of claim 16, wherein the instructions include instructions that cause the implantable medical device to use, in assessing the effectiveness of the electrostimulation, information about one or more of:

a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput.

18. The processor-readable medium of claim 17, wherein the first and second pulses are substantially identical in time and duration.

19. The processor-readable medium of claim 18, wherein the instructions include instructions that cause the implantable medical device to receive a command to adjust one or more parameters of the pacing profile, the command provided from an external device using a wireless interface, wherein the one or more adjustable parameters include one or more of a pulse width, a pulse amplitude, or a timing offset between initiation or termination of respective pulses.

20. The processor-readable medium of claim 16, wherein the instructions include instructions that cause the implantable medical device to update, for the subsequent pacing electrostimulation profile, an energy of at least one of the first and second pulses, using the assessed effectiveness.